Best TWAS P=1.531293e-08 · Best GWAS P=1.285509e-08 conditioned to 0.1337539
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Unc80 | gene expression | ENSRNOG00000028362 | 0.18 | 0.12 | enet | 162 | 0.13 | 9.5e-15 | -4.106 | -5.1 | 3.0e-07 | 0.73 | 0.99 | 0.01 | FALSE |
2 | Adipose | NA | gene expression | ENSRNOG00000063935 | 0.08 | 0.02 | top1 | 1 | 0.02 | 1.5e-03 | -5.658 | 5.7 | 1.5e-08 | -0.88 | 0.08 | 0.24 | TRUE |
3 | BLA | Lancl1 | gene expression | ENSRNOG00000013557 | 0.39 | 0.35 | top1 | 1 | 0.35 | 2.2e-19 | -5.448 | 5.4 | 5.1e-08 | -0.78 | 0.31 | 0.69 | FALSE |
4 | Brain | Lancl1 | gene expression | ENSRNOG00000013557 | 0.27 | 0.55 | enet | 443 | 0.56 | 4.0e-62 | -5.214 | 5.2 | 2.0e-07 | -0.82 | 0.30 | 0.70 | FALSE |
5 | Brain | NA | gene expression | ENSRNOG00000068276 | 0.08 | 0.06 | blup | 2374 | 0.07 | 8.3e-07 | -5.446 | 5.6 | 2.2e-08 | -0.79 | 0.32 | 0.68 | FALSE |
6 | Brain | Lancl1 | mRNA stability | ENSRNOG00000013557 | 0.08 | 0.07 | top1 | 1 | 0.07 | 2.1e-07 | -5.411 | 5.4 | 6.3e-08 | -0.83 | 0.34 | 0.63 | FALSE |
7 | LHb | Kansl1l | mRNA stability | ENSRNOG00000028149 | 0.21 | 0.09 | enet | 87 | 0.10 | 2.9e-03 | -5.519 | -5.1 | 3.0e-07 | 0.70 | 0.31 | 0.41 | FALSE |
8 | Liver | Acadl | gene expression | ENSRNOG00000012966 | 0.08 | 0.02 | enet | 339 | 0.02 | 9.0e-04 | -0.047 | -5.2 | 1.7e-07 | 0.73 | 0.57 | 0.13 | FALSE |
9 | Liver | Lancl1 | gene expression | ENSRNOG00000013557 | 0.59 | 0.34 | enet | 260 | 0.34 | 5.7e-39 | -5.377 | 5.4 | 5.9e-08 | -0.83 | 0.30 | 0.70 | FALSE |
10 | Liver | Lancl1 | mRNA stability | ENSRNOG00000013557 | 0.04 | 0.01 | top1 | 1 | 0.01 | 1.0e-02 | -5.377 | 5.4 | 7.6e-08 | -0.79 | 0.07 | 0.04 | FALSE |
11 | NAcc | NA | gene expression | ENSRNOG00000068276 | 0.12 | 0.08 | blup | 2373 | 0.09 | 4.6e-07 | -5.477 | 5.5 | 4.0e-08 | -0.78 | 0.32 | 0.68 | FALSE |
12 | NAcc | Kansl1l | mRNA stability | ENSRNOG00000028149 | 0.04 | 0.04 | top1 | 1 | 0.04 | 6.4e-04 | -5.402 | -5.4 | 6.6e-08 | 0.82 | 0.10 | 0.06 | FALSE |
13 | OFC | Lancl1 | gene expression | ENSRNOG00000013557 | 0.45 | 0.43 | top1 | 1 | 0.43 | 2.2e-11 | -5.513 | 5.5 | 3.5e-08 | -0.78 | 0.23 | 0.74 | FALSE |
14 | OFC | NA | gene expression | ENSRNOG00000068276 | 0.21 | 0.21 | top1 | 1 | 0.21 | 1.3e-05 | -5.493 | 5.5 | 4.0e-08 | -0.81 | 0.13 | 0.10 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.