Best TWAS P=2.85e-09 · Best GWAS P=2.85e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.24 | 2417 | 0.11 | 7.3e-12 | -5.63 | 1.82e-08 | 0.75 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.17 | 2417 | 0.07 | 1.7e-08 | -5.58 | 2.45e-08 | 0.75 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089621.1 | 0.15 | 2417 | 0.07 | 7.6e-08 | 5.56 | 2.66e-08 | 0.75 | FALSE |
| Adipose | Kl | alternative TSS | XM_039089809.1 | 0.06 | 1234 | 0.04 | 1.8e-05 | 5.23 | 1.70e-07 | 0.33 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.03 | 1441 | 0.02 | 6.6e-03 | -5.77 | 7.73e-09 | 0.44 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_006248749.4 | 0.03 | 1441 | 0.02 | 4.3e-03 | -5.53 | 3.23e-08 | 0.47 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.04 | 1441 | 0.02 | 1.6e-03 | -5.74 | 9.52e-09 | 0.55 | FALSE |
| Adipose | LOC102549089 | gene expression | LOC102549089 | 0.12 | 19 | 0.05 | 1.9e-06 | -5.77 | 8.09e-09 | 0.51 | FALSE |
| Adipose | N4bp2l1 | gene expression | N4bp2l1 | 0.36 | 19 | 0.28 | 1.1e-31 | 5.31 | 1.08e-07 | 0.85 | FALSE |
| Adipose | Stard13 | gene expression | Stard13 | 0.29 | 126 | 0.23 | 4.3e-25 | -5.3 | 1.13e-07 | 0.07 | FALSE |
| Adipose | Xab2 | gene expression | Xab2 | 0.13 | 35 | 0.05 | 5.7e-06 | 5.36 | 8.13e-08 | 0.79 | FALSE |
| Adipose | Elavl1 | isoform ratio | XM_039089620.1 | 0.26 | 219 | 0.12 | 4.8e-13 | 5.32 | 1.02e-07 | 0.75 | FALSE |
| Adipose | Elavl1 | mRNA stability | Elavl1 | 0.27 | 130 | 0.12 | 6.3e-13 | -5.42 | 6.01e-08 | 0.75 | FALSE |
| Adipose | N4bp2l1 | mRNA stability | N4bp2l1 | 0.05 | 597 | 0.03 | 1.6e-04 | 5.55 | 2.80e-08 | 0.74 | FALSE |
| BLA | N4bp2l2 | alternative polyA | XM_039089150.1 | 0.06 | 702 | 0.04 | 3.0e-03 | 5.66 | 1.52e-08 | 0.66 | FALSE |
| BLA | Brca2 | gene expression | Brca2 | 0.37 | 93 | 0.27 | 7.3e-15 | -5.48 | 4.28e-08 | 0.84 | TRUE |
| BLA | Insr | gene expression | Insr | 0.7 | 10 | 0.55 | 2.7e-34 | 5.2 | 1.95e-07 | 0.74 | FALSE |
| BLA | N4bp2l2 | gene expression | N4bp2l2 | 0.08 | 1 | 0.05 | 1.6e-03 | -5.35 | 8.82e-08 | 0.06 | FALSE |
| BLA | Snapc2 | gene expression | Snapc2 | 0.16 | 15 | 0.06 | 3.7e-04 | 5.65 | 1.62e-08 | 0.66 | FALSE |
| BLA | Stard13 | gene expression | Stard13 | 0.15 | 1 | 0.12 | 7.8e-07 | -5.61 | 1.97e-08 | 0.77 | FALSE |
| BLA | N4bp2l2 | isoform ratio | XM_039089150.1 | 0.06 | 702 | 0.05 | 9.4e-04 | 5.62 | 1.88e-08 | 0.74 | FALSE |
| BLA | Snapc2 | isoform ratio | XM_039089313.1 | 0.15 | 2285 | 0.04 | 5.8e-03 | 5.27 | 1.40e-07 | 0.38 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.34 | 21 | 0.2 | 3.9e-11 | -5.63 | 1.77e-08 | 0.77 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.33 | 1836 | 0.2 | 1.0e-10 | 5.62 | 1.97e-08 | 0.77 | FALSE |
| BLA | Brca2 | mRNA stability | Brca2 | 0.41 | 24 | 0.29 | 7.6e-16 | -5.44 | 5.27e-08 | 0.86 | TRUE |
| BLA | Cers4 | mRNA stability | Cers4 | 0.15 | 1 | 0.07 | 2.1e-04 | -5.25 | 1.52e-07 | 0.1 | FALSE |
| BLA | Stard13 | mRNA stability | Stard13 | 0.09 | 1442 | 0.07 | 1.1e-04 | 5.21 | 1.86e-07 | 0.31 | FALSE |
| Brain | Stxbp2 | alternative polyA | XM_039089805.1 | 0.13 | 1 | 0.12 | 4.9e-11 | 5.19 | 2.14e-07 | 0.76 | FALSE |
| Brain | Arhgef18 | alternative TSS | NM_001395655.1 | 0.09 | 9 | 0.05 | 3.3e-05 | -5.57 | 2.58e-08 | 0.74 | FALSE |
| Brain | Arhgef18 | alternative TSS | XM_039089307.1 | 0.1 | 11 | 0.05 | 4.3e-05 | 5.55 | 2.92e-08 | 0.66 | FALSE |
| Brain | Elavl1 | alternative TSS | NM_001108848.1 | 0.13 | 1 | 0.04 | 6.4e-05 | -5.53 | 3.14e-08 | 0.51 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 2.4e-18 | -5.2 | 1.99e-07 | 0.72 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 3.5e-18 | -5.22 | 1.81e-07 | 0.72 | FALSE |
| Brain | Elavl1 | gene expression | Elavl1 | 0.1 | 2419 | 0.05 | 2.7e-05 | -5.53 | 3.23e-08 | 0.7 | FALSE |
| Brain | Insr | isoform ratio | XM_039089096.1 | 0.23 | 1 | 0.16 | 1.5e-14 | 5.2 | 1.99e-07 | 0.7 | FALSE |
| Brain | Insr | isoform ratio | XM_039089097.1 | 0.09 | 1555 | 0.06 | 1.8e-06 | 5.7 | 1.19e-08 | 0.57 | FALSE |
| Brain | Pex11g | isoform ratio | NM_001105902.1 | 0.04 | 1 | 0.04 | 1.7e-04 | -5.17 | 2.28e-07 | 0.26 | FALSE |
| Brain | Elavl1 | mRNA stability | Elavl1 | 0.14 | 12 | 0.07 | 5.1e-07 | 5.59 | 2.27e-08 | 0.57 | FALSE |
| Eye | Elavl1 | intron excision ratio | chr12_2667464_2684652 | 0.69 | 8 | 0.37 | 1.3e-06 | 5.56 | 2.71e-08 | 0.69 | FALSE |
| LHb | Cers4 | gene expression | Cers4 | 0.3 | 12 | 0.11 | 1.3e-03 | 5.47 | 4.44e-08 | 0.48 | FALSE |
| LHb | Insr | intron excision ratio | chr12_1257822_1307450 | 0.71 | 407 | 0.34 | 5.1e-09 | -5.41 | 6.44e-08 | 0.49 | FALSE |
| LHb | Brca2 | mRNA stability | Brca2 | 0.29 | 435 | 0.12 | 7.5e-04 | 5.28 | 1.30e-07 | 0.64 | FALSE |
| Liver | Stxbp2 | alternative polyA | XM_039089804.1 | 0.42 | 31 | 0.28 | 2.4e-31 | -5.32 | 1.02e-07 | 0.61 | FALSE |
| Liver | Elavl1 | alternative TSS | NM_001108848.1 | 0.09 | 1 | 0.01 | 7.9e-03 | -5.44 | 5.39e-08 | 0.06 | FALSE |
| Liver | Elavl1 | alternative TSS | XM_039089621.1 | 0.06 | 1 | 0.02 | 1.5e-03 | 5.44 | 5.39e-08 | 0.09 | FALSE |
| Liver | Mcoln1 | gene expression | Mcoln1 | 0.07 | 1 | 0.03 | 1.2e-04 | -5.22 | 1.80e-07 | 0.29 | FALSE |
| Liver | Insr | intron excision ratio | chr12_1257822_1307450 | 0.4 | 1 | 0.19 | 6.8e-21 | -5.21 | 1.85e-07 | 0.71 | TRUE |
| Liver | LOC120095871 | intron excision ratio | chr12_3871255_3873703 | 0.15 | 1117 | 0.09 | 2.7e-10 | 5.42 | 5.93e-08 | 0.74 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.2 | 76 | 0.1 | 4.0e-11 | 5.5 | 3.69e-08 | 0.66 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.18 | 19 | 0.07 | 2.4e-08 | 5.74 | 9.52e-09 | 0.73 | FALSE |
| Liver | Brca2 | mRNA stability | Brca2 | 0.18 | 431 | 0.13 | 2.3e-14 | 5.55 | 2.86e-08 | 0.86 | FALSE |
| Liver | Elavl1 | mRNA stability | Elavl1 | 0.08 | 2417 | 0.04 | 4.1e-05 | 5.21 | 1.91e-07 | 0.61 | FALSE |
| Liver | Pet100 | mRNA stability | Pet100 | 0.5 | 1831 | 0.31 | 3.8e-35 | 5.78 | 7.30e-09 | 0.76 | FALSE |
| Liver | Pex11g | mRNA stability | Pex11g | 0.28 | 17 | 0.18 | 1.6e-19 | -5.18 | 2.24e-07 | 0.62 | FALSE |
| NAcc | Elavl1 | alternative TSS | NM_001108848.1 | 0.04 | 1 | 0.02 | 7.4e-04 | -5.67 | 1.41e-08 | 0.31 | FALSE |
| NAcc | Snapc2 | alternative TSS | XM_039089313.1 | 0.07 | 16 | 0.03 | 2.4e-04 | -5.22 | 1.78e-07 | 0.76 | FALSE |
| NAcc | Arhgef18 | gene expression | Arhgef18 | 0.09 | 1543 | 0.04 | 2.3e-05 | -5.46 | 4.75e-08 | 0.45 | FALSE |
| NAcc | Insr | gene expression | Insr | 0.78 | 53 | 0.6 | 1.2e-86 | -5.21 | 1.91e-07 | 0.72 | FALSE |
| NAcc | Snapc2 | gene expression | Snapc2 | 0.15 | 1 | 0.07 | 1.1e-08 | 5.36 | 8.30e-08 | 0.84 | TRUE |
| NAcc | Stxbp2 | gene expression | Stxbp2 | 0.1 | 1833 | 0.05 | 7.4e-07 | -5.79 | 7.25e-09 | 0.77 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089913.1 | 0.07 | 1121 | 0.06 | 1.7e-07 | 5.48 | 4.28e-08 | 0.73 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089914.1 | 0.07 | 1121 | 0.06 | 2.3e-07 | -5.49 | 4.10e-08 | 0.72 | FALSE |
| NAcc | Snapc2 | isoform ratio | NM_001415804.1 | 0.07 | 6 | 0.04 | 2.4e-05 | 5.32 | 1.05e-07 | 0.21 | FALSE |
| NAcc | Snapc2 | isoform ratio | XM_039089313.1 | 0.06 | 1 | 0.03 | 9.3e-05 | -5.26 | 1.44e-07 | 0.23 | FALSE |
| NAcc | Stard13 | isoform ratio | XM_039089671.1 | 0.05 | 1 | 0.02 | 1.1e-03 | 5.27 | 1.34e-07 | 0.07 | FALSE |
| NAcc | LOC120095871 | intron excision ratio | chr12_3870992_3873703 | 0.11 | 1 | 0.1 | 4.3e-11 | 5.19 | 2.07e-07 | 0.73 | FALSE |
| NAcc | LOC120095871 | intron excision ratio | chr12_3871255_3873703 | 0.07 | 1121 | 0.05 | 6.9e-07 | 5.49 | 3.96e-08 | 0.73 | FALSE |
| NAcc | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.1 | 6 | 0.05 | 1.2e-06 | -5.62 | 1.88e-08 | 0.69 | FALSE |
| NAcc | Brca2 | mRNA stability | Brca2 | 0.23 | 24 | 0.16 | 2.9e-18 | -5.18 | 2.23e-07 | 0.85 | FALSE |
| NAcc | Pet100 | mRNA stability | Pet100 | 0.26 | 65 | 0.16 | 8.7e-18 | 5.4 | 6.55e-08 | 0.71 | TRUE |
| PL | Stard13 | alternative polyA | XM_039089671.1 | 0.03 | 1442 | 0.02 | 6.3e-03 | -5.41 | 6.24e-08 | 0.45 | FALSE |
| PL | Stard13 | alternative polyA | XM_039089671.1 | 0.03 | 1442 | 0.02 | 5.6e-03 | -5.45 | 5.02e-08 | 0.41 | FALSE |
| PL | N4bp2l1 | alternative TSS | NM_001035222.2 | 0.05 | 1 | 0.04 | 1.4e-05 | 5.37 | 7.84e-08 | 0.69 | FALSE |
| PL | N4bp2l1 | alternative TSS | XM_039089675.1 | 0.05 | 1 | 0.04 | 1.4e-05 | -5.35 | 8.82e-08 | 0.69 | FALSE |
| PL | Stard13 | gene expression | Stard13 | 0.11 | 1 | 0.07 | 4.0e-08 | -5.21 | 1.87e-07 | 0.43 | FALSE |
| PL | N4bp2l1 | isoform ratio | NM_001035222.2 | 0.03 | 1 | 0.01 | 1.5e-02 | 5.2 | 2.02e-07 | 0.12 | FALSE |
| PL | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.29 | 1836 | 0.16 | 7.5e-17 | -5.75 | 8.82e-09 | 0.78 | FALSE |
| PL | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.25 | 1836 | 0.12 | 1.6e-13 | 5.66 | 1.53e-08 | 0.77 | FALSE |
| PL | Snapc2 | mRNA stability | Snapc2 | 0.52 | 68 | 0.31 | 2.8e-35 | 5.38 | 7.30e-08 | 0.88 | FALSE |
| PL | Stard13 | mRNA stability | Stard13 | 0.05 | 73 | 0.03 | 4.7e-04 | -5.35 | 8.60e-08 | 0.38 | FALSE |
| pVTA | Snapc2 | alternative TSS | NM_001415804.1 | 0.21 | 11 | 0.07 | 6.9e-04 | 5.59 | 2.30e-08 | 0.4 | FALSE |
| pVTA | Snapc2 | alternative TSS | XM_039089313.1 | 0.32 | 42 | 0.04 | 1.0e-02 | -5.22 | 1.77e-07 | 0.19 | FALSE |
| pVTA | Arhgef18 | gene expression | Arhgef18 | 0.22 | 1543 | 0.14 | 9.7e-07 | -5.64 | 1.72e-08 | 0.54 | FALSE |
| pVTA | Cers4 | gene expression | Cers4 | 0.42 | 2124 | 0.32 | 2.6e-14 | 5.29 | 1.25e-07 | 0.38 | FALSE |
| pVTA | Insr | gene expression | Insr | 0.6 | 1 | 0.3 | 1.6e-13 | -5.94 | 2.85e-09 | 0.99 | TRUE |
| pVTA | Snapc2 | isoform ratio | XM_039089313.1 | 0.51 | 13 | 0.08 | 3.1e-04 | 5.26 | 1.43e-07 | 0.18 | FALSE |
| pVTA | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.34 | 17 | 0.18 | 2.0e-08 | -5.31 | 1.07e-07 | 0.61 | FALSE |
| pVTA | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.3 | 146 | 0.15 | 4.0e-07 | -5.56 | 2.72e-08 | 0.61 | FALSE |
| pVTA | Brca2 | mRNA stability | Brca2 | 0.2 | 1 | 0.13 | 3.6e-06 | -5.2 | 2.02e-07 | 0.64 | FALSE |
| RMTg | Cers4 | gene expression | Cers4 | 0.29 | 2124 | 0.09 | 2.4e-03 | 5.56 | 2.66e-08 | 0.63 | FALSE |
| RMTg | LOC120095871 | intron excision ratio | chr12_3870992_3873703 | 0.2 | 30 | 0.14 | 1.3e-04 | 5.33 | 9.65e-08 | 0.59 | TRUE |