Best TWAS P = 1.22e-08 · Best GWAS P= 2.86e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Fn1 | isoform ratio | XM_006245152.5 | 0.03 | 94 | 0.02 | 5.5e-03 | 5.34 | 9.13e-08 | 0.11 | FALSE |
| Adipose | Fn1 | intron excision ratio | chr9_80662594_80663712 | 0.04 | 1397 | 0.03 | 2.7e-04 | 5.21 | 1.85e-07 | 0.1 | FALSE |
| Adipose | Fn1 | mRNA stability | Fn1 | 0.04 | 1397 | 0.02 | 3.1e-03 | -5.7 | 1.22e-08 | 0.41 | TRUE |
| IL | Fn1 | gene expression | Fn1 | 0.29 | 33 | 0.19 | 2.7e-05 | -5.23 | 1.66e-07 | 0.19 | FALSE |
| LHb | Fn1 | gene expression | Fn1 | 0.43 | 184 | 0.26 | 6.4e-07 | -5.43 | 5.62e-08 | 0.12 | FALSE |
| Liver | Atic | gene expression | Atic | 0.04 | 1 | 0.04 | 7.9e-05 | 5.43 | 5.48e-08 | 0.47 | FALSE |
| Liver | LOC102554186 | gene expression | LOC102554186 | 0.15 | 1 | 0.14 | 3.7e-15 | -5.3 | 1.19e-07 | 0.48 | FALSE |
| OFC | Atic | gene expression | Atic | 0.7 | 18 | 0.47 | 7.0e-13 | 5.27 | 1.35e-07 | 0.14 | FALSE |
| OFC | Fn1 | gene expression | Fn1 | 0.46 | 37 | 0.42 | 3.6e-11 | -5.65 | 1.64e-08 | 0.34 | FALSE |
| PL | Fn1 | intron excision ratio | chr9_80674521_80675826 | 0.02 | 1 | 0.04 | 4.1e-05 | -5.46 | 4.63e-08 | 0.24 | FALSE |
| pVTA | Fn1 | gene expression | Fn1 | 0.4 | 1397 | 0.49 | 1.1e-44 | -5.25 | 1.52e-07 | 0.06 | FALSE |