Best TWAS P=1.39e-08 · Best GWAS P=1.29e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Kansl1l | alternative TSS | XM_039084605.1 | 0.03 | 85 | 0 | 2.4e-01 | -5.41 | 6.32e-08 | 0.3 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084606.1 | 0.11 | 1 | 0.05 | 3.7e-06 | -5.36 | 8.53e-08 | 0.39 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084605.1 | 0.03 | 89 | 0 | 8.1e-02 | -5.43 | 5.68e-08 | 0.27 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084606.1 | 0.1 | 2491 | 0.02 | 1.3e-03 | 5.53 | 3.21e-08 | 0.67 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084608.1 | 0.08 | 1 | 0 | 2.2e-01 | 5.66 | 1.53e-08 | 0.04 | FALSE |
| Adipose | Kansl1l | isoform ratio | XM_039084605.1 | 0.03 | 120 | 0 | 1.2e-01 | -5.19 | 2.12e-07 | 0.26 | TRUE |
| Adipose | Kansl1l | isoform ratio | XM_039084606.1 | 0.12 | 1 | 0.05 | 2.3e-06 | -5.36 | 8.53e-08 | 0.47 | FALSE |
| Adipose | Kansl1l | intron excision ratio | chr9_68300220_68306570 | 0.15 | 1 | 0.05 | 1.2e-06 | 5.38 | 7.59e-08 | 0.5 | FALSE |
| BLA | Map2 | alternative polyA | NM_013066.1 | 0.12 | 1 | 0.07 | 7.7e-05 | 5.4 | 6.68e-08 | 0.62 | FALSE |
| BLA | Map2 | alternative polyA | XM_017596293.2 | 0.17 | 1 | 0.12 | 9.1e-07 | -5.4 | 6.68e-08 | 0.9 | TRUE |
| BLA | Lancl1 | gene expression | Lancl1 | 0.35 | 3 | 0.29 | 4.0e-16 | 5.26 | 1.46e-07 | 0.66 | FALSE |
| BLA | Map2 | mRNA stability | Map2 | 0.39 | 94 | 0.26 | 2.5e-14 | -5.32 | 1.02e-07 | 0.9 | FALSE |
| Brain | Map2 | alternative polyA | NM_013066.1 | 0.56 | 31 | 0.37 | 1.1e-35 | -5.35 | 8.79e-08 | 0.92 | TRUE |
| Brain | Map2 | alternative polyA | XM_017596293.2 | 0.56 | 19 | 0.36 | 7.3e-35 | 5.33 | 1.00e-07 | 0.92 | FALSE |
| Brain | Lancl1 | gene expression | Lancl1 | 0.27 | 25 | 0.47 | 1.3e-48 | 5.23 | 1.66e-07 | 0.7 | TRUE |
| Brain | Rpe | gene expression | Rpe | 0.03 | 38 | 0.02 | 1.0e-02 | -5.67 | 1.39e-08 | 0.58 | TRUE |
| Brain | Kansl1l | isoform ratio | XM_039084628.1 | 0.03 | 2491 | 0.02 | 9.7e-03 | -5.44 | 5.19e-08 | 0.42 | TRUE |
| Brain | Lancl1 | isoform ratio | XM_039082905.1 | 0.03 | 9 | 0.01 | 1.4e-02 | -5.41 | 6.47e-08 | 0.51 | TRUE |
| Brain | Lancl1 | mRNA stability | Lancl1 | 0.09 | 3 | 0.07 | 9.7e-07 | 5.44 | 5.29e-08 | 0.7 | FALSE |
| IL | Lancl1 | isoform ratio | NM_053723.1 | 0.21 | 1 | 0.2 | 1.9e-05 | -5.48 | 4.33e-08 | 0.09 | FALSE |
| LHb | Kansl1l | mRNA stability | Kansl1l | 0.27 | 20 | 0.08 | 5.1e-03 | -5.5 | 3.74e-08 | 0.5 | TRUE |
| Liver | Lancl1 | alternative polyA | NM_053723.1 | 0.39 | 1 | 0.21 | 3.7e-23 | -5.41 | 6.48e-08 | 0.64 | FALSE |
| Liver | Lancl1 | alternative polyA | XM_039082904.1 | 0.38 | 1 | 0.21 | 7.2e-23 | 5.41 | 6.48e-08 | 0.64 | FALSE |
| Liver | Lancl1 | alternative TSS | NM_053723.1 | 0.04 | 1 | 0 | 1.6e-01 | 5.43 | 5.77e-08 | 0.03 | FALSE |
| Liver | Lancl1 | gene expression | Lancl1 | 0.59 | 37 | 0.33 | 2.1e-37 | 5.4 | 6.66e-08 | 0.7 | FALSE |
| Liver | Lancl1 | isoform ratio | NM_053723.1 | 0.34 | 1 | 0.21 | 8.3e-23 | -5.41 | 6.48e-08 | 0.64 | FALSE |
| Liver | Lancl1 | mRNA stability | Lancl1 | 0.06 | 1 | 0.03 | 6.3e-04 | -5.38 | 7.59e-08 | 0.11 | FALSE |
| NAcc | Map2 | alternative polyA | XM_017596293.2 | 0.07 | 1 | 0.04 | 1.0e-05 | -5.34 | 9.42e-08 | 0.77 | TRUE |
| NAcc | Lancl1 | isoform ratio | XM_039082905.1 | 0.02 | 1 | 0.03 | 3.3e-04 | 5.45 | 5.11e-08 | 0.07 | TRUE |
| NAcc | Kansl1l | mRNA stability | Kansl1l | 0.04 | 1 | 0.02 | 1.5e-03 | 5.38 | 7.59e-08 | 0.05 | FALSE |
| pVTA | Acadl | gene expression | Acadl | 0.22 | 1 | 0.23 | 1.7e-10 | -5.32 | 1.06e-07 | 0.52 | FALSE |