Best TWAS P=3.29151e-13 · Best GWAS P=2.083284e-13 conditioned to NaN
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Elk3 | gene expression | ENSRNOG00000004367 | 0.11 | 0.05 | blup | 2579 | 0.05 | 2.5e-06 | -5.98 | 6.1 | 9.2e-10 | -0.50 | 0.71 | 0.29 | FALSE |
2 | Adipose | Hal | gene expression | ENSRNOG00000004502 | 0.03 | 0.00 | blup | 2432 | 0.01 | 6.9e-02 | -6.56 | -6.6 | 3.5e-11 | 0.56 | 0.30 | 0.34 | FALSE |
3 | Adipose | Vezt | gene expression | ENSRNOG00000006514 | 0.11 | 0.08 | top1 | 1 | 0.08 | 3.2e-09 | -5.22 | -5.2 | 1.8e-07 | 0.57 | 1.00 | 0.00 | FALSE |
4 | Adipose | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.34 | 0.19 | lasso | 16 | 0.20 | 1.0e-21 | -5.36 | -5.5 | 4.9e-08 | 0.49 | 0.99 | 0.01 | FALSE |
5 | Adipose | Cep83 | intron excision ratio | chr7:29322957:29325469 | 0.03 | 0.01 | blup | 2703 | 0.02 | 1.8e-03 | -5.26 | -6.1 | 1.0e-09 | 0.52 | 0.55 | 0.32 | FALSE |
6 | Adipose | Vezt | mRNA stability | ENSRNOG00000006514 | 0.07 | 0.04 | blup | 2570 | 0.06 | 5.0e-07 | -5.88 | -6.2 | 7.1e-10 | 0.60 | 0.74 | 0.26 | FALSE |
7 | BLA | Ntn4 | gene expression | ENSRNOG00000005573 | 0.06 | 0.02 | blup | 2475 | 0.03 | 8.1e-03 | -0.19 | 5.1 | 3.5e-07 | -0.59 | 0.42 | 0.39 | FALSE |
8 | BLA | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.17 | 0.06 | blup | 3125 | 0.11 | 2.6e-06 | -4.02 | -5.1 | 3.4e-07 | 0.43 | 0.99 | 0.01 | FALSE |
9 | BLA | Nudt4 | gene expression | ENSRNOG00000009094 | 0.46 | 0.35 | lasso | 64 | 0.38 | 1.9e-21 | 4.57 | 5.7 | 1.0e-08 | -0.31 | 0.95 | 0.05 | FALSE |
10 | BLA | Metap2 | gene expression | ENSRNOG00000021881 | 0.08 | 0.07 | top1 | 1 | 0.07 | 1.9e-04 | -6.76 | 6.8 | 1.4e-11 | -0.67 | 0.08 | 0.18 | FALSE |
11 | BLA | Mir331 | gene expression | ENSRNOG00000035543 | 0.06 | 0.04 | blup | 2366 | 0.06 | 5.1e-04 | -5.41 | 6.7 | 2.9e-11 | -0.64 | 0.75 | 0.22 | FALSE |
12 | BLA | Fgd6 | gene expression | ENSRNOG00000054515 | 0.11 | 0.13 | top1 | 1 | 0.13 | 2.7e-07 | -5.62 | -5.6 | 1.9e-08 | 0.67 | 0.90 | 0.03 | FALSE |
13 | BLA | Tmcc3 | isoform ratio | ENSRNOT00000102476 | 0.10 | 0.02 | blup | 2424 | 0.04 | 3.2e-03 | -5.49 | -6.6 | 3.9e-11 | 0.57 | 0.49 | 0.39 | FALSE |
14 | BLA | Lta4h | intron excision ratio | chr7:27997602:27999743 | 0.07 | 0.01 | blup | 2332 | 0.02 | 2.6e-02 | -3.61 | -5.4 | 6.3e-08 | 0.51 | 0.58 | 0.30 | FALSE |
15 | BLA | Vezt | intron excision ratio | chr7:28557619:28560958 | 0.07 | 0.01 | blup | 2571 | 0.01 | 6.6e-02 | 2.95 | 5.7 | 1.6e-08 | -0.50 | 0.50 | 0.20 | FALSE |
16 | BLA | Tmcc3 | intron excision ratio | chr7:29100427:29159418 | 0.12 | 0.10 | lasso | 10 | 0.11 | 1.0e-06 | -3.90 | 5.4 | 8.4e-08 | -0.45 | 0.75 | 0.23 | FALSE |
17 | BLA | Tmcc3 | intron excision ratio | chr7:29133627:29159418 | 0.07 | 0.02 | blup | 2424 | 0.04 | 4.3e-03 | -5.65 | -6.2 | 5.0e-10 | 0.60 | 0.44 | 0.38 | FALSE |
18 | BLA | Vezt | mRNA stability | ENSRNOG00000006514 | 0.40 | 0.42 | top1 | 1 | 0.42 | 4.0e-24 | -6.01 | 6.0 | 1.9e-09 | -0.66 | 0.81 | 0.19 | FALSE |
19 | BLA | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.11 | 0.11 | top1 | 1 | 0.11 | 3.0e-06 | -6.72 | 6.7 | 1.8e-11 | -0.61 | 0.20 | 0.47 | FALSE |
20 | Brain | Cdk17 | gene expression | ENSRNOG00000004148 | 0.12 | 0.06 | enet | 78 | 0.07 | 1.8e-07 | -5.08 | 5.4 | 8.4e-08 | -0.25 | 1.00 | 0.00 | FALSE |
21 | Brain | Lta4h | gene expression | ENSRNOG00000004494 | 0.05 | 0.04 | top1 | 1 | 0.04 | 9.1e-05 | -6.15 | 6.2 | 7.7e-10 | -0.60 | 0.11 | 0.04 | FALSE |
22 | Brain | Vezt | gene expression | ENSRNOG00000006514 | 0.24 | 0.22 | blup | 2571 | 0.23 | 1.2e-20 | -6.16 | -6.0 | 2.7e-09 | 0.67 | 0.58 | 0.42 | FALSE |
23 | Brain | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.49 | 0.32 | blup | 2574 | 0.34 | 6.1e-32 | -5.44 | -5.6 | 1.7e-08 | 0.50 | 0.99 | 0.01 | FALSE |
24 | Brain | Socs2 | gene expression | ENSRNOG00000008965 | 0.22 | 0.09 | enet | 118 | 0.11 | 5.0e-10 | -6.72 | 6.5 | 1.0e-10 | -0.56 | 0.07 | 0.93 | FALSE |
25 | Brain | Nudt4 | gene expression | ENSRNOG00000009094 | 0.86 | 0.63 | lasso | 57 | 0.74 | 8.6e-100 | 5.10 | 5.6 | 1.9e-08 | 0.01 | 1.00 | 0.00 | FALSE |
26 | Brain | Fgd6 | gene expression | ENSRNOG00000054515 | 0.16 | 0.23 | top1 | 1 | 0.23 | 8.6e-21 | -5.71 | -5.7 | 1.1e-08 | 0.64 | 0.96 | 0.04 | FALSE |
27 | Brain | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.05 | 0.02 | blup | 2332 | 0.03 | 9.8e-04 | -6.15 | 5.8 | 8.1e-09 | -0.61 | 0.35 | 0.60 | FALSE |
28 | Brain | Vezt | mRNA stability | ENSRNOG00000006514 | 0.20 | 0.20 | lasso | 28 | 0.20 | 1.6e-18 | -5.66 | 5.7 | 1.0e-08 | -0.69 | 0.70 | 0.30 | TRUE |
29 | Eye | Lta4h | gene expression | ENSRNOG00000004494 | 0.41 | 0.04 | lasso | 24 | 0.07 | 3.0e-02 | -5.77 | 5.6 | 1.9e-08 | -0.62 | 0.26 | 0.41 | FALSE |
30 | Eye | Fgd6 | gene expression | ENSRNOG00000054515 | 0.52 | 0.13 | blup | 2560 | 0.15 | 2.3e-03 | -5.37 | -6.2 | 5.0e-10 | 0.60 | 0.43 | 0.17 | FALSE |
31 | Eye | Elk3 | isoform ratio | ENSRNOT00000005911 | 0.36 | 0.01 | blup | 2579 | 0.10 | 1.2e-02 | -5.80 | -6.7 | 2.9e-11 | 0.59 | 0.26 | 0.45 | FALSE |
32 | IL | Vezt | gene expression | ENSRNOG00000006514 | 0.29 | 0.20 | lasso | 4 | 0.26 | 7.2e-07 | -5.36 | -6.5 | 7.4e-11 | 0.57 | 0.60 | 0.38 | FALSE |
33 | IL | Vezt | mRNA stability | ENSRNOG00000006514 | 0.23 | 0.06 | blup | 2568 | 0.10 | 2.4e-03 | -5.13 | 6.0 | 2.5e-09 | -0.61 | 0.60 | 0.26 | FALSE |
34 | LHb | Ntn4 | gene expression | ENSRNOG00000005573 | 0.21 | 0.04 | blup | 2473 | 0.06 | 1.6e-02 | -6.57 | -5.7 | 9.9e-09 | 0.61 | 0.32 | 0.49 | FALSE |
35 | LHb | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.41 | 0.09 | blup | 3118 | 0.22 | 7.2e-06 | -4.41 | -6.5 | 9.6e-11 | 0.58 | 0.73 | 0.23 | FALSE |
36 | LHb | Cdk17 | isoform ratio | ENSRNOT00000109496 | 0.18 | 0.05 | blup | 2984 | 0.11 | 1.4e-03 | -4.16 | 5.2 | 1.6e-07 | -0.48 | 0.50 | 0.26 | FALSE |
37 | LHb | Vezt | mRNA stability | ENSRNOG00000006514 | 0.40 | 0.20 | enet | 84 | 0.21 | 1.1e-05 | -5.72 | 6.0 | 1.5e-09 | -0.69 | 0.60 | 0.40 | FALSE |
38 | Liver | Amdhd1 | gene expression | ENSRNOG00000005266 | 0.37 | 0.31 | lasso | 40 | 0.34 | 1.7e-39 | -4.88 | -5.7 | 9.4e-09 | 0.53 | 1.00 | 0.00 | FALSE |
39 | Liver | Ntn4 | gene expression | ENSRNOG00000005573 | 0.10 | 0.05 | blup | 2475 | 0.06 | 4.3e-07 | -5.61 | -6.6 | 4.2e-11 | 0.66 | 0.46 | 0.54 | FALSE |
40 | Liver | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.42 | 0.43 | enet | 320 | 0.46 | 1.8e-56 | -5.36 | -5.4 | 7.1e-08 | 0.47 | 0.99 | 0.01 | FALSE |
41 | Liver | Nudt4 | gene expression | ENSRNOG00000009094 | 0.10 | 0.06 | enet | 21 | 0.06 | 4.1e-07 | 5.29 | -5.2 | 2.4e-07 | -0.01 | 0.97 | 0.01 | TRUE |
42 | Liver | Ube2n | gene expression | ENSRNOG00000058053 | 0.03 | 0.02 | enet | 7 | 0.02 | 1.1e-03 | 4.82 | -5.7 | 1.4e-08 | 0.30 | 0.82 | 0.01 | FALSE |
43 | Liver | Mrpl42 | intron excision ratio | chr7:30140191:30141604 | 0.03 | 0.02 | enet | 32 | 0.02 | 2.2e-03 | 6.08 | 5.4 | 5.3e-08 | 0.01 | 0.53 | 0.06 | FALSE |
44 | Liver | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.11 | 0.11 | top1 | 1 | 0.11 | 6.2e-12 | -5.99 | 6.0 | 2.1e-09 | -0.59 | 0.90 | 0.10 | FALSE |
45 | Liver | Socs2 | mRNA stability | ENSRNOG00000008965 | 0.04 | 0.02 | blup | 3463 | 0.02 | 5.8e-03 | 6.68 | -6.1 | 9.2e-10 | 0.44 | 0.78 | 0.08 | FALSE |
46 | NAcc | AABR07056633.1 | alternative TSS | ENSRNOT00000104436 | 0.04 | 0.03 | blup | 2952 | 0.03 | 1.5e-03 | -4.76 | -5.1 | 2.9e-07 | 0.41 | 0.93 | 0.04 | FALSE |
47 | NAcc | Elk3 | gene expression | ENSRNOG00000004367 | 0.04 | 0.00 | blup | 2578 | 0.02 | 1.6e-02 | 3.20 | 6.2 | 5.5e-10 | -0.40 | 0.54 | 0.24 | FALSE |
48 | NAcc | Lta4h | gene expression | ENSRNOG00000004494 | 0.04 | 0.05 | top1 | 1 | 0.05 | 8.4e-05 | -6.42 | 6.4 | 1.4e-10 | -0.58 | 0.12 | 0.11 | FALSE |
49 | NAcc | Vezt | gene expression | ENSRNOG00000006514 | 0.10 | 0.09 | blup | 2569 | 0.14 | 1.4e-10 | -5.44 | -5.8 | 8.7e-09 | 0.55 | 0.97 | 0.03 | FALSE |
50 | NAcc | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.12 | 0.13 | lasso | 6 | 0.13 | 1.0e-09 | -5.83 | -6.2 | 6.1e-10 | 0.56 | 0.94 | 0.06 | TRUE |
51 | NAcc | Tmcc3 | isoform ratio | ENSRNOT00000102476 | 0.05 | 0.02 | blup | 2420 | 0.04 | 8.4e-04 | -4.37 | -5.1 | 3.0e-07 | 0.51 | 0.50 | 0.26 | FALSE |
52 | NAcc | Tmcc3 | intron excision ratio | chr7:29133627:29159418 | 0.05 | 0.03 | blup | 2420 | 0.05 | 1.4e-04 | -5.71 | -6.2 | 6.7e-10 | 0.58 | 0.57 | 0.40 | FALSE |
53 | NAcc | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.06 | 0.05 | lasso | 7 | 0.06 | 3.2e-05 | -6.62 | 6.0 | 1.6e-09 | -0.64 | 0.39 | 0.60 | FALSE |
54 | NAcc | Vezt | mRNA stability | ENSRNOG00000006514 | 0.14 | 0.08 | lasso | 10 | 0.11 | 1.5e-08 | -6.17 | 5.7 | 1.2e-08 | -0.68 | 0.85 | 0.15 | FALSE |
55 | OFC | Vezt | gene expression | ENSRNOG00000006514 | 0.38 | 0.25 | enet | 117 | 0.28 | 3.0e-07 | -6.43 | -6.6 | 3.9e-11 | 0.67 | 0.40 | 0.60 | FALSE |
56 | OFC | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.19 | 0.16 | top1 | 1 | 0.16 | 1.1e-04 | -6.20 | -6.2 | 5.5e-10 | 0.63 | 0.14 | 0.08 | FALSE |
57 | OFC | Socs2 | isoform ratio | ENSRNOT00000103867 | 0.33 | 0.15 | top1 | 1 | 0.15 | 2.3e-04 | 5.78 | -5.8 | 7.5e-09 | 0.04 | 0.15 | 0.05 | FALSE |
58 | OFC | Vezt | mRNA stability | ENSRNOG00000006514 | 0.24 | 0.12 | blup | 2568 | 0.14 | 3.2e-04 | -5.72 | 6.2 | 4.2e-10 | -0.67 | 0.60 | 0.36 | FALSE |
59 | PL | Socs2 | alternative polyA | ENSRNOT00000011948 | 0.10 | 0.05 | top1 | 1 | 0.05 | 1.5e-04 | 6.57 | 6.6 | 4.9e-11 | -0.34 | 0.54 | 0.26 | FALSE |
60 | PL | Socs2 | alternative polyA | ENSRNOT00000103867 | 0.09 | 0.04 | enet | 16 | 0.04 | 2.5e-04 | 6.57 | -6.5 | 8.9e-11 | 0.20 | 0.86 | 0.14 | FALSE |
61 | PL | Vezt | gene expression | ENSRNOG00000006514 | 0.35 | 0.39 | lasso | 7 | 0.41 | 4.8e-33 | -5.11 | -5.8 | 8.7e-09 | 0.60 | 0.98 | 0.03 | FALSE |
62 | PL | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.07 | 0.06 | lasso | 18 | 0.07 | 1.0e-05 | -5.36 | -6.0 | 2.1e-09 | 0.36 | 0.48 | 0.52 | TRUE |
63 | PL | Socs2 | gene expression | ENSRNOG00000008965 | 0.05 | 0.04 | top1 | 1 | 0.04 | 9.1e-04 | -7.28 | 7.3 | 3.3e-13 | -0.69 | 0.06 | 0.44 | TRUE |
64 | PL | Nudt4 | gene expression | ENSRNOG00000009094 | 0.68 | 0.51 | enet | 84 | 0.55 | 1.1e-49 | -4.84 | 5.9 | 3.9e-09 | -0.34 | 1.00 | 0.00 | FALSE |
65 | PL | Fgd6 | gene expression | ENSRNOG00000054515 | 0.07 | 0.09 | lasso | 7 | 0.10 | 5.4e-08 | -5.44 | -5.4 | 5.3e-08 | 0.50 | 0.81 | 0.19 | FALSE |
66 | PL | Socs2 | isoform ratio | ENSRNOT00000011948 | 0.10 | 0.05 | top1 | 1 | 0.05 | 1.4e-04 | 5.99 | 6.0 | 2.1e-09 | -0.30 | 0.76 | 0.02 | TRUE |
67 | PL | Socs2 | isoform ratio | ENSRNOT00000103867 | 0.10 | 0.05 | top1 | 1 | 0.05 | 1.3e-04 | 5.99 | -6.0 | 2.1e-09 | 0.30 | 0.76 | 0.02 | FALSE |
68 | PL | Vezt | mRNA stability | ENSRNOG00000006514 | 0.27 | 0.38 | top1 | 1 | 0.38 | 1.6e-30 | -5.94 | 5.9 | 2.8e-09 | -0.66 | 0.86 | 0.14 | FALSE |
69 | PL | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.05 | 0.05 | top1 | 1 | 0.05 | 1.2e-04 | -6.04 | 6.0 | 1.5e-09 | -0.59 | 0.20 | 0.03 | FALSE |
70 | PL | Cradd | mRNA stability | ENSRNOG00000008507 | 0.09 | 0.08 | top1 | 1 | 0.07 | 2.3e-06 | -6.65 | 6.6 | 2.9e-11 | -0.63 | 0.44 | 0.34 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.