Best TWAS P=2.652011e-07 · Best GWAS P=8.157494e-08 conditioned to 0.091996
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Tmeff2 | mRNA stability | ENSRNOG00000016623 | 0.48 | 0.10 | lasso | 9 | 0.16 | 7.1e-15 | -5.1 | 5.1 | 3.4e-07 | -0.48 | 0.38 | 0.62 | FALSE |
| 2 | IL | Tmeff2 | gene expression | ENSRNOG00000016623 | 0.25 | 0.09 | top1 | 1 | 0.09 | 3.8e-03 | -5.1 | 5.1 | 3.3e-07 | -0.95 | 0.12 | 0.05 | FALSE |
| 3 | Liver | Tmeff2 | alternative TSS | ENSRNOT00000081677 | 0.02 | 0.01 | blup | 2471 | 0.01 | 2.4e-02 | -4.3 | -5.1 | 2.8e-07 | 0.89 | 0.49 | 0.21 | FALSE |
| 4 | Liver | Tmeff2 | alternative TSS | ENSRNOT00000081677 | 0.02 | 0.01 | blup | 2471 | 0.01 | 3.2e-02 | -4.3 | -5.1 | 2.7e-07 | 0.90 | 0.44 | 0.20 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.