Best TWAS P = 5.63e-09 · Best GWAS P= 1.39e-08 conditioned to 9.24e-02
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Iqgap2 | alternative TSS | NM_001427125.1 | 0.04 | 1 | 0.01 | 8.4e-03 | 5.4 | 6.70e-08 | 0.03 | FALSE |
| Adipose | Iqgap2 | alternative TSS | XM_063281081.1 | 0.04 | 1 | 0.02 | 5.6e-03 | -5.4 | 6.70e-08 | 0.03 | FALSE |
| Adipose | Enc1 | gene expression | Enc1 | 0.03 | 5 | 0.02 | 4.5e-03 | 5.44 | 5.32e-08 | 0.3 | FALSE |
| Adipose | Gcnt4 | gene expression | Gcnt4 | 0.52 | 73 | 0.37 | 1.8e-42 | -5.32 | 1.05e-07 | 0.36 | FALSE |
| Adipose | Gfm2 | gene expression | Gfm2 | 0.29 | 61 | 0.24 | 8.2e-26 | 5.41 | 6.38e-08 | 0.43 | FALSE |
| Adipose | Iqgap2 | gene expression | Iqgap2 | 0.21 | 123 | 0.16 | 2.1e-17 | -5.28 | 1.30e-07 | 0.44 | FALSE |
| Adipose | Ankra2 | mRNA stability | Ankra2 | 0.02 | 1 | 0.02 | 2.6e-03 | 5.25 | 1.50e-07 | 0.06 | FALSE |
| Adipose | Hexb | mRNA stability | Hexb | 0.29 | 179 | 0.2 | 1.7e-21 | -5.25 | 1.52e-07 | 0.38 | FALSE |
| Adipose | Hmgcr | mRNA stability | Hmgcr | 0.04 | 1 | 0.02 | 2.8e-03 | 5.23 | 1.68e-07 | 0.03 | FALSE |
| BLA | Ankdd1b | alternative TSS | XM_039103462.2 | 0.15 | 3 | 0.15 | 1.4e-08 | 5.32 | 1.01e-07 | 0.42 | FALSE |
| BLA | Ankdd1b | alternative TSS | XM_039103462.2 | 0.2 | 1 | 0.11 | 1.6e-06 | 5.21 | 1.93e-07 | 0.43 | FALSE |
| BLA | F2r | gene expression | F2r | 0.68 | 3136 | 0.59 | 2.7e-38 | -5.31 | 1.12e-07 | 0.51 | FALSE |
| BLA | Arhgef28 | isoform ratio | NM_001415065.1 | 0.08 | 1 | 0.07 | 1.3e-04 | -5.61 | 2.08e-08 | 0.22 | FALSE |
| BLA | LOC102550768 | isoform ratio | XR_005500528.2 | 0.12 | 2763 | 0.14 | 1.1e-07 | -5.22 | 1.76e-07 | 0.17 | FALSE |
| BLA | LOC102550768 | intron excision ratio | chr2_30578924_30579840 | 0.14 | 2763 | 0.14 | 1.1e-07 | 5.28 | 1.33e-07 | 0.19 | FALSE |
| Brain | F2r | gene expression | F2r | 0.74 | 42 | 0.81 | 1.4e-124 | -5.3 | 1.15e-07 | 0.51 | FALSE |
| Brain | Hmgcr | gene expression | Hmgcr | 0.02 | 2019 | 0.02 | 2.4e-03 | -5.21 | 1.90e-07 | 0.31 | FALSE |
| Brain | LOC134485820 | gene expression | LOC134485820 | 0.22 | 1 | 0.23 | 6.9e-21 | -5.38 | 7.34e-08 | 0.58 | FALSE |
| Brain | Poc5 | gene expression | Poc5 | 0.14 | 1 | 0.11 | 3.2e-10 | -5.28 | 1.29e-07 | 0.51 | FALSE |
| Brain | LOC102550768 | isoform ratio | XR_005500529.2 | 0.07 | 47 | 0.13 | 3.8e-12 | -5.63 | 1.83e-08 | 0.26 | FALSE |
| Brain | Poc5 | isoform ratio | NM_001025647.1 | 0.03 | 1 | 0.03 | 4.0e-04 | -5.24 | 1.62e-07 | 0.08 | FALSE |
| Brain | Poc5 | isoform ratio | XM_039101919.2 | 0.03 | 1 | 0.03 | 7.8e-04 | 5.21 | 1.88e-07 | 0.07 | FALSE |
| Brain | LOC102550768 | intron excision ratio | chr2_30576265_30576827 | 0.05 | 1 | 0.01 | 3.6e-02 | -5.61 | 2.04e-08 | 0.09 | FALSE |
| Brain | LOC102550768 | intron excision ratio | chr2_30578924_30580812 | 0.17 | 26 | 0.27 | 4.3e-25 | -5.28 | 1.26e-07 | 0.23 | FALSE |
| Brain | LOC102551152 | mRNA stability | LOC102551152 | 0.04 | 3042 | 0.05 | 1.8e-05 | -5.3 | 1.18e-07 | 0.26 | FALSE |
| Eye | Polk | alternative polyA | NM_138516.1 | 0.25 | 1 | 0.08 | 2.2e-02 | 5.4 | 6.61e-08 | 0.06 | FALSE |
| Eye | Polk | alternative polyA | XM_039101672.2 | 0.25 | 1 | 0.08 | 2.4e-02 | -5.4 | 6.61e-08 | 0.06 | FALSE |
| Eye | Hexb | mRNA stability | Hexb | 0.21 | 187 | 0.14 | 4.0e-03 | -5.21 | 1.93e-07 | 0.29 | FALSE |
| IC | Ankdd1b | alternative TSS | XM_039103459.2 | 0.13 | 1 | 0.12 | 1.1e-05 | -5.24 | 1.57e-07 | 0.14 | FALSE |
| IC | Cert1 | gene expression | Cert1 | 0.05 | 2125 | 0.03 | 1.9e-02 | -5.22 | 1.80e-07 | 0.29 | FALSE |
| IC | LOC134485820 | gene expression | LOC134485820 | 0.37 | 27 | 0.4 | 5.3e-18 | -5.27 | 1.39e-07 | 0.52 | FALSE |
| IC | LOC102550768 | intron excision ratio | chr2_30578798_30580812 | 0.26 | 19 | 0.29 | 1.3e-12 | -5.39 | 7.06e-08 | 0.56 | FALSE |
| IC | LOC102550768 | intron excision ratio | chr2_30578924_30579840 | 0.5 | 31 | 0.41 | 2.7e-18 | 5.2 | 1.96e-07 | 0.3 | FALSE |
| IC | LOC102550768 | intron excision ratio | chr2_30579883_30580812 | 0.5 | 62 | 0.46 | 4.3e-21 | 5.39 | 6.90e-08 | 0.34 | FALSE |
| IL | Ankdd1b | alternative polyA | XM_008760686.4 | 0.13 | 1 | 0.02 | 1.3e-01 | -5.34 | 9.12e-08 | 0.05 | FALSE |
| IL | LOC134485820 | gene expression | LOC134485820 | 0.38 | 1 | 0.26 | 4.7e-07 | -5.33 | 9.81e-08 | 0.18 | FALSE |
| IL | LOC102550768 | intron excision ratio | chr2_30579883_30580812 | 0.13 | 1 | 0.11 | 1.1e-03 | 5.55 | 2.83e-08 | 0.07 | FALSE |
| LHb | F2r | gene expression | F2r | 0.79 | 1 | 0.4 | 1.3e-10 | -5.32 | 1.04e-07 | 0.41 | FALSE |
| LHb | Ankra2 | mRNA stability | Ankra2 | 0.19 | 1 | 0.11 | 1.5e-03 | 5.6 | 2.17e-08 | 0.12 | FALSE |
| Liver | Polk | alternative polyA | XM_039101672.2 | 0.11 | 34 | 0.13 | 1.4e-14 | -5.83 | 5.63e-09 | 0.35 | TRUE |
| Liver | Ankdd1b | gene expression | Ankdd1b | 0.02 | 1 | 0.01 | 6.1e-02 | 5.37 | 7.91e-08 | 0.03 | FALSE |
| Liver | Hexb | gene expression | Hexb | 0.41 | 24 | 0.34 | 1.5e-38 | -5.41 | 6.21e-08 | 0.38 | FALSE |
| Liver | Iqgap2 | gene expression | Iqgap2 | 0.06 | 31 | 0.03 | 9.2e-05 | 5.28 | 1.27e-07 | 0.38 | FALSE |
| Liver | LOC120100671 | gene expression | LOC120100671 | 0.33 | 1 | 0.28 | 9.3e-31 | 5.36 | 8.10e-08 | 0.54 | FALSE |
| Liver | Polk | isoform ratio | NM_138516.1 | 0.06 | 36 | 0.05 | 4.4e-06 | 5.77 | 7.92e-09 | 0.32 | FALSE |
| Liver | Polk | isoform ratio | XM_039101672.2 | 0.06 | 14 | 0.05 | 2.2e-06 | -5.77 | 8.12e-09 | 0.31 | FALSE |
| NAcc | Polk | alternative polyA | NM_138516.1 | 0.06 | 1 | 0.06 | 8.5e-09 | 5.28 | 1.29e-07 | 0.54 | FALSE |
| NAcc | Polk | alternative polyA | XM_039101672.2 | 0.06 | 1 | 0.06 | 5.8e-09 | -5.28 | 1.29e-07 | 0.54 | FALSE |
| NAcc | Ankdd1b | isoform ratio | XM_039103460.2 | 0.06 | 1 | 0.06 | 5.9e-09 | 5.25 | 1.55e-07 | 0.5 | FALSE |
| NAcc | LOC102550768 | intron excision ratio | chr2_30467590_30469768 | 0.03 | 27 | 0.03 | 1.6e-05 | 5.71 | 1.12e-08 | 0.36 | FALSE |
| NAcc | LOC120100677 | intron excision ratio | chr2_30467590_30469768 | 0.03 | 27 | 0.03 | 1.6e-05 | 5.74 | 9.35e-09 | 0.35 | FALSE |
| NAcc | LOC134485824 | intron excision ratio | chr2_30467590_30469768 | 0.03 | 27 | 0.03 | 1.6e-05 | 5.74 | 9.45e-09 | 0.35 | FALSE |
| NAcc | LOC102550768 | mRNA stability | LOC102550768 | 0.14 | 4 | 0.19 | 1.0e-27 | 5.38 | 7.45e-08 | 0.28 | FALSE |
| OFC | F2r | gene expression | F2r | 0.85 | 1 | 0.48 | 5.9e-13 | -5.32 | 1.04e-07 | 0.48 | FALSE |
| OFC | LOC102551027 | gene expression | LOC102551027 | 0.17 | 1 | 0.13 | 5.3e-04 | 5.46 | 4.86e-08 | 0.06 | FALSE |
| OFC | LOC134485820 | gene expression | LOC134485820 | 0.49 | 26 | 0.35 | 3.2e-09 | -5.37 | 8.09e-08 | 0.41 | FALSE |
| OFC | LOC102550768 | intron excision ratio | chr2_30578798_30580812 | 0.24 | 149 | 0.18 | 4.2e-05 | -5.63 | 1.76e-08 | 0.39 | FALSE |
| OFC | LOC102550768 | intron excision ratio | chr2_30579883_30580812 | 0.47 | 130 | 0.43 | 1.8e-11 | 5.52 | 3.39e-08 | 0.45 | FALSE |
| OFC | LOC102550768 | mRNA stability | LOC102550768 | 0.45 | 92 | 0.38 | 5.7e-10 | 5.49 | 3.95e-08 | 0.49 | FALSE |
| PL | Ankdd1b | alternative polyA | XM_008760686.4 | 0.11 | 1 | 0.18 | 1.0e-19 | -5.3 | 1.15e-07 | 0.57 | FALSE |
| PL | Ankdd1b | alternative polyA | XM_039103460.2 | 0.14 | 14 | 0.21 | 4.0e-22 | 5.53 | 3.20e-08 | 0.44 | FALSE |
| PL | Ankdd1b | alternative TSS | XM_039103462.2 | 0.11 | 39 | 0.09 | 1.2e-09 | 5.29 | 1.25e-07 | 0.19 | FALSE |
| PL | Ankdd1b | alternative TSS | XM_039103459.2 | 0.05 | 19 | 0.07 | 1.5e-08 | -5.57 | 2.48e-08 | 0.42 | FALSE |
| PL | Ankdd1b | gene expression | Ankdd1b | 0.22 | 24 | 0.31 | 5.7e-35 | -5.73 | 1.00e-08 | 0.52 | FALSE |
| PL | F2r | gene expression | F2r | 0.69 | 26 | 0.68 | 1.8e-102 | -5.33 | 9.99e-08 | 0.4 | FALSE |
| PL | LOC102551152 | gene expression | LOC102551152 | 0.05 | 18 | 0.07 | 7.5e-08 | -5.6 | 2.11e-08 | 0.54 | FALSE |
| PL | Poc5 | gene expression | Poc5 | 0.12 | 1 | 0.08 | 2.4e-09 | -5.21 | 1.93e-07 | 0.42 | FALSE |
| PL | Ankdd1b | isoform ratio | XM_039103460.2 | 0.02 | 1 | 0.03 | 1.7e-04 | 5.3 | 1.15e-07 | 0.09 | FALSE |
| PL | LOC102550768 | isoform ratio | XR_005500528.2 | 0.23 | 21 | 0.23 | 4.0e-25 | -5.33 | 1.01e-07 | 0.12 | FALSE |
| PL | LOC102550768 | isoform ratio | XR_005500530.2 | 0.03 | 1 | 0.03 | 4.8e-04 | -5.4 | 6.64e-08 | 0.2 | FALSE |
| PL | Arhgef28 | intron excision ratio | chr2_31227347_31234535 | 0.06 | 39 | 0.08 | 9.1e-09 | 5.3 | 1.17e-07 | 0.12 | FALSE |
| PL | Arhgef28 | mRNA stability | Arhgef28 | 0.26 | 1 | 0.08 | 6.6e-09 | -5.52 | 3.44e-08 | 0.73 | FALSE |
| pVTA | Polk | alternative polyA | NM_138516.1 | 0.12 | 93 | 0.12 | 1.4e-09 | 5.53 | 3.16e-08 | 0.37 | FALSE |
| pVTA | Polk | alternative polyA | XM_039101672.2 | 0.12 | 90 | 0.12 | 1.4e-09 | -5.54 | 3.10e-08 | 0.37 | FALSE |
| pVTA | LOC102551152 | gene expression | LOC102551152 | 0.05 | 21 | 0.04 | 3.9e-04 | -5.24 | 1.61e-07 | 0.32 | FALSE |
| pVTA | Poc5 | gene expression | Poc5 | 0.04 | 2414 | 0.04 | 1.5e-04 | -5.21 | 1.92e-07 | 0.39 | FALSE |
| pVTA | Polk | isoform ratio | NM_138516.1 | 0.07 | 2125 | 0.09 | 1.6e-07 | 5.21 | 1.87e-07 | 0.38 | FALSE |
| pVTA | Polk | isoform ratio | XM_039101672.2 | 0.07 | 2125 | 0.09 | 1.1e-07 | -5.21 | 1.93e-07 | 0.38 | FALSE |
| pVTA | Poc5 | mRNA stability | Poc5 | 0.04 | 2414 | 0.04 | 5.6e-04 | 5.21 | 1.90e-07 | 0.43 | FALSE |
| RMTg | Ankdd1b | alternative TSS | XM_039103459.2 | 0.13 | 18 | 0.15 | 1.1e-04 | -5.33 | 9.70e-08 | 0.4 | FALSE |
| RMTg | Iqgap2 | alternative TSS | XM_063281081.1 | 0.21 | 31 | 0.22 | 1.4e-06 | -5.26 | 1.45e-07 | 0.42 | FALSE |