Best TWAS P=1.892483e-07 · Best GWAS P=1.622557e-07 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Plpp3 | gene expression | ENSRNOG00000008116 | 0.19 | 0.05 | enet | 6 | 0.05 | 3.2e-06 | 5.1 | -5.1 | 3.4e-07 | -0.98 | 0.53 | 0.47 | FALSE |
| 2 | Liver | C8b | gene expression | ENSRNOG00000007639 | 0.08 | 0.05 | enet | 20 | 0.06 | 1.0e-06 | 5.2 | -5.2 | 1.9e-07 | -1.00 | 0.54 | 0.46 | TRUE |
| 3 | Liver | AABR07049503.1 | isoform ratio | ENSRNOT00000087040 | 0.45 | 0.36 | top1 | 1 | 0.36 | 4.0e-42 | 5.1 | -5.1 | 3.5e-07 | -0.98 | 0.44 | 0.56 | FALSE |
| 4 | Liver | AABR07049503.1 | intron excision ratio | chr5:120008720:120009113 | 0.03 | 0.01 | top1 | 1 | 0.01 | 4.0e-02 | 5.1 | 5.1 | 2.8e-07 | 0.98 | 0.04 | 0.03 | FALSE |
| 5 | PL | Plpp3 | gene expression | ENSRNOG00000008116 | 0.09 | 0.05 | lasso | 3 | 0.05 | 1.5e-04 | 5.2 | 5.1 | 2.6e-07 | 0.98 | 0.54 | 0.45 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.