Best TWAS P=2.28584e-08 · Best GWAS P=9.554982e-08 conditioned to 0.05254515
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pmfbp1 | gene expression | ENSRNOG00000014505 | 0.15 | 0.08 | top1 | 1 | 0.08 | 8.8e-09 | 5.2 | 5.2 | 2.1e-07 | 0.80 | 0.14 | 0.86 | FALSE |
| 2 | Brain | Pmfbp1 | gene expression | ENSRNOG00000014505 | 0.21 | 0.16 | lasso | 10 | 0.19 | 1.5e-17 | 5.3 | 5.5 | 4.8e-08 | 0.96 | 0.16 | 0.84 | FALSE |
| 3 | Brain | NA | gene expression | ENSRNOG00000038766 | 0.08 | 0.04 | lasso | 15 | 0.06 | 5.4e-06 | 3.3 | -5.2 | 1.8e-07 | -0.77 | 0.23 | 0.76 | FALSE |
| 4 | Brain | Ist1 | intron excision ratio | chr19:37652320:37654806 | 0.09 | 0.04 | lasso | 4 | 0.05 | 2.4e-05 | 4.4 | 5.6 | 2.3e-08 | 0.71 | 0.33 | 0.60 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.