Hub : Traits : Left kidney weight : ← →

chr12:27,006-6,045,485

Trait: Left kidney weight

Best TWAS P=9.045465e-11 · Best GWAS P=5.519619e-11 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.14	0.12	top1	1	0.12	7.1e-13	-6.1120	6.1	9.8e-10	-0.82	0.17	0.83	FALSE
2	Adipose	N4bp2l2	alternative polyA	ENSRNOT00000118063	0.14	0.12	top1	1	0.12	3.9e-13	-6.1120	-6.1	9.8e-10	0.82	0.17	0.83	FALSE
3	Adipose	B3glct	alternative polyA	ENSRNOT00000083484	0.06	0.03	enet	19	0.03	2.4e-04	-1.1884	5.1	3.4e-07	-0.81	0.96	0.02	FALSE
4	Adipose	B3glct	alternative polyA	ENSRNOT00000116254	0.06	0.03	enet	18	0.03	1.9e-04	-1.1884	-5.3	1.1e-07	0.82	0.96	0.02	TRUE
5	Adipose	Pet100	alternative TSS	ENSRNOT00000071928	0.22	0.10	enet	116	0.13	3.4e-14	-5.7372	5.5	3.2e-08	-0.77	0.44	0.56	FALSE
6	Adipose	Pet100	alternative TSS	ENSRNOT00000107172	0.22	0.10	enet	122	0.13	2.6e-14	-4.6400	-5.5	3.0e-08	0.77	0.46	0.54	FALSE
7	Adipose	Xab2	gene expression	ENSRNOG00000000988	0.14	0.05	top1	1	0.05	2.2e-06	-5.9216	-5.9	3.2e-09	0.80	0.11	0.86	FALSE
8	Adipose	Trappc5	gene expression	ENSRNOG00000001003	0.09	0.03	top1	1	0.03	9.9e-05	-5.8507	-5.9	4.9e-09	0.50	0.09	0.29	FALSE
9	Adipose	Evi5l	gene expression	ENSRNOG00000001034	0.09	0.00	top1	1	0.00	4.2e-01	-5.6368	5.6	1.7e-08	-0.61	0.06	0.03	TRUE
10	Adipose	Insr	gene expression	ENSRNOG00000029986	0.13	0.02	top1	1	0.02	4.3e-03	-6.0007	6.0	2.0e-09	-0.81	0.05	0.06	FALSE
11	Adipose	N4bp2l1	gene expression	ENSRNOG00000059322	0.32	0.23	lasso	16	0.24	1.2e-26	-6.3366	-6.4	2.1e-10	0.66	0.08	0.92	FALSE
12	Adipose	Timm44	isoform ratio	ENSRNOT00000096445	0.08	0.00	enet	152	0.01	3.5e-02	-5.9239	5.5	3.8e-08	-0.88	0.16	0.36	FALSE
13	Adipose	Timm44	isoform ratio	ENSRNOT00000098717	0.08	0.00	enet	173	0.00	1.2e-01	-5.9239	-5.5	3.7e-08	0.88	0.15	0.32	FALSE
14	Adipose	N4bp2l2	isoform ratio	ENSRNOT00000001468	0.05	0.01	blup	681	0.02	6.1e-03	-6.1120	5.3	1.1e-07	-0.78	0.15	0.65	TRUE
15	Adipose	Pet100	isoform ratio	ENSRNOT00000071928	0.23	0.11	enet	64	0.13	1.8e-14	-5.7372	5.5	2.9e-08	-0.75	0.35	0.65	FALSE
16	Adipose	Pet100	isoform ratio	ENSRNOT00000107172	0.23	0.09	enet	66	0.13	2.6e-14	-5.7372	-5.6	2.3e-08	0.76	0.34	0.66	FALSE
17	Adipose	Zfp958	isoform ratio	ENSRNOT00000102786	0.03	0.00	enet	169	0.01	6.9e-03	-5.9384	6.1	1.1e-09	-0.92	0.23	0.46	TRUE
18	Adipose	Zfp958	intron excision ratio	chr12:3971128:3971331	0.03	0.00	blup	1113	0.01	2.8e-02	-6.0387	6.0	2.0e-09	-0.82	0.17	0.39	FALSE
19	Adipose	Zfp958	intron excision ratio	chr12:3971128:3973820	0.04	0.01	blup	1113	0.02	5.3e-03	-5.9166	-5.6	2.6e-08	0.94	0.21	0.54	FALSE
20	Adipose	Fry	mRNA stability	ENSRNOG00000000894	0.08	0.05	blup	2970	0.05	2.0e-06	-4.1958	-5.4	6.9e-08	0.71	1.00	0.00	FALSE
21	Adipose	Snapc2	mRNA stability	ENSRNOG00000001056	0.11	0.00	enet	19	0.01	5.0e-02	-3.3854	-6.0	1.8e-09	0.66	0.47	0.04	FALSE
22	Adipose	Elavl1	mRNA stability	ENSRNOG00000001069	0.16	0.06	blup	2406	0.07	9.4e-09	-5.8162	6.0	1.9e-09	-0.82	0.24	0.76	FALSE
23	BLA	Pet100	alternative TSS	ENSRNOT00000110166	0.11	0.05	top1	1	0.05	7.7e-04	-5.8797	-5.9	4.1e-09	0.45	0.07	0.07	TRUE
24	BLA	Stard13	gene expression	ENSRNOG00000001090	0.17	0.13	top1	1	0.13	2.4e-07	-5.9285	5.9	3.1e-09	-0.97	0.28	0.64	FALSE
25	BLA	Brca2	gene expression	ENSRNOG00000001111	0.36	0.24	top1	1	0.24	5.4e-13	-5.9608	6.0	2.5e-09	-0.98	0.24	0.76	FALSE
26	BLA	Insr	gene expression	ENSRNOG00000029986	0.59	0.33	blup	1546	0.39	5.5e-22	-5.7901	6.1	1.4e-09	-0.97	0.18	0.82	FALSE
27	BLA	N4bp2l1	gene expression	ENSRNOG00000059322	0.13	0.08	top1	1	0.08	5.7e-05	-5.9210	-5.9	3.2e-09	0.77	0.12	0.23	FALSE
28	BLA	Camsap3	isoform ratio	ENSRNOT00000096347	0.13	0.01	lasso	20	0.03	9.2e-03	-5.6847	-5.8	7.6e-09	0.96	0.14	0.81	FALSE
29	BLA	Camsap3	isoform ratio	ENSRNOT00000101379	0.13	0.06	top1	1	0.06	4.4e-04	-5.8797	5.9	4.1e-09	-0.66	0.07	0.09	FALSE
30	BLA	Pet100	intron excision ratio	chr12:1680794:1680963	0.36	0.12	lasso	13	0.19	1.7e-10	-5.6368	-5.8	6.7e-09	0.78	0.28	0.72	FALSE
31	BLA	Pet100	intron excision ratio	chr12:1680995:1681508	0.35	0.12	lasso	11	0.20	9.8e-11	-5.6368	5.6	1.8e-08	-0.68	0.29	0.71	FALSE
32	BLA	NA	intron excision ratio	chr12:3870992:3873703	0.08	0.03	blup	1116	0.04	3.3e-03	-6.0126	-6.0	1.9e-09	0.95	0.23	0.65	FALSE
33	BLA	Cers4	mRNA stability	ENSRNOG00000001072	0.16	0.06	blup	2109	0.08	5.0e-05	-5.8162	5.7	1.3e-08	-0.77	0.32	0.67	FALSE
34	BLA	Stard13	mRNA stability	ENSRNOG00000001090	0.08	0.05	blup	1438	0.05	1.3e-03	-4.9704	5.4	6.4e-08	-0.80	0.49	0.32	FALSE
35	BLA	Brca2	mRNA stability	ENSRNOG00000001111	0.19	0.12	top1	1	0.12	9.3e-07	-5.9608	6.0	2.5e-09	-0.97	0.23	0.70	FALSE
36	Brain	Zfp958	alternative TSS	ENSRNOT00000103468	0.17	0.12	blup	1115	0.13	7.5e-12	-4.2770	5.5	3.4e-08	-0.79	0.98	0.01	TRUE
37	Brain	Zfp958	alternative TSS	ENSRNOT00000104360	0.17	0.12	lasso	14	0.13	1.0e-11	-4.2770	-5.2	2.5e-07	0.67	0.99	0.01	FALSE
38	Brain	NA	alternative TSS	ENSRNOT00000115928	0.08	0.03	enet	60	0.05	1.4e-05	-0.0061	5.2	1.9e-07	-0.80	0.62	0.23	FALSE
39	Brain	Rxfp2	gene expression	ENSRNOG00000000897	0.13	0.07	blup	3311	0.12	3.5e-11	-4.7077	-5.9	4.3e-09	0.79	0.98	0.02	FALSE
40	Brain	Elavl1	gene expression	ENSRNOG00000001069	0.07	0.01	blup	2406	0.02	4.4e-03	-5.8121	-5.9	3.3e-09	0.87	0.28	0.64	FALSE
41	Brain	Brca2	gene expression	ENSRNOG00000001111	0.42	0.32	lasso	21	0.33	6.8e-31	-6.1971	6.1	8.3e-10	-0.98	0.15	0.85	FALSE
42	Brain	Arhgef18	gene expression	ENSRNOG00000028090	0.12	0.06	enet	11	0.08	1.2e-07	-5.8943	-6.2	6.1e-10	0.90	0.22	0.78	FALSE
43	Brain	N4bp2l1	gene expression	ENSRNOG00000059322	0.06	0.05	lasso	2	0.05	3.5e-05	-6.3765	-6.4	1.8e-10	0.83	0.07	0.92	FALSE
44	Brain	Rxfp2	intron excision ratio	chr12:4945988:4950591	0.07	0.01	lasso	6	0.02	7.0e-03	-4.5320	-5.5	5.0e-08	0.44	0.78	0.02	TRUE
45	Brain	Rxfp2	intron excision ratio	chr12:4945988:4950702	0.05	0.01	lasso	5	0.02	7.8e-03	-4.4357	5.4	7.3e-08	-0.44	0.76	0.03	FALSE
46	Brain	Trappc5	intron excision ratio	chr12:1737769:1740114	0.05	0.02	enet	18	0.03	5.1e-04	-4.5838	-6.3	3.8e-10	0.72	0.49	0.36	FALSE
47	Brain	Zfp958	intron excision ratio	chr12:3971128:3973820	0.21	0.14	enet	38	0.16	4.9e-15	-5.9905	-5.4	5.4e-08	0.89	0.26	0.74	FALSE
48	Brain	NA	intron excision ratio	chr12:3870992:3873703	0.13	0.10	lasso	14	0.10	1.0e-09	-5.9427	-5.9	2.7e-09	0.96	0.26	0.74	FALSE
49	Brain	Elavl1	mRNA stability	ENSRNOG00000001069	0.19	0.03	lasso	22	0.07	2.6e-07	-5.8290	5.9	3.2e-09	-0.53	0.27	0.73	FALSE
50	Brain	Brca2	mRNA stability	ENSRNOG00000001111	0.29	0.17	lasso	14	0.18	3.2e-16	-6.1971	6.2	5.8e-10	-0.98	0.15	0.85	FALSE
51	Brain	Insr	mRNA stability	ENSRNOG00000029986	0.72	0.55	enet	150	0.60	8.8e-69	-5.8156	5.2	2.2e-07	-0.66	0.34	0.66	FALSE
52	Eye	Fry	gene expression	ENSRNOG00000000894	0.41	0.13	blup	2972	0.18	9.6e-04	-4.2318	-5.4	5.4e-08	0.67	0.52	0.07	FALSE
53	Eye	Elavl1	intron excision ratio	chr12:2667464:2684652	0.69	0.25	lasso	30	0.31	1.3e-05	-5.7499	6.0	2.0e-09	-0.84	0.24	0.60	FALSE
54	IL	Zfp958l1	alternative TSS	ENSRNOT00000035992	0.20	0.00	top1	1	0.00	2.5e-01	-6.0071	6.0	1.9e-09	-0.93	0.10	0.06	FALSE
55	IL	Zfp958l1	alternative TSS	ENSRNOT00000119165	0.19	0.02	top1	1	0.02	1.3e-01	-6.0071	-6.0	1.9e-09	0.93	0.10	0.06	FALSE
56	IL	Insr	intron excision ratio	chr12:1257822:1307450	0.73	0.50	top1	1	0.50	6.5e-14	-5.8156	5.8	6.0e-09	-0.68	0.28	0.71	FALSE
57	IL	Pds5b	mRNA stability	ENSRNOG00000001098	0.19	0.08	blup	795	0.11	1.5e-03	-6.1360	5.2	1.6e-07	-0.60	0.16	0.34	FALSE
58	LHb	Brca2	mRNA stability	ENSRNOG00000001111	0.19	0.12	top1	1	0.12	9.6e-04	-6.1404	6.1	8.2e-10	-0.61	0.03	0.09	FALSE
59	Liver	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.06	0.02	top1	1	0.02	1.5e-03	-6.4821	6.5	9.0e-11	-0.95	0.02	0.36	TRUE
60	Liver	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.10	0.04	blup	681	0.07	2.3e-08	-6.1415	6.4	1.5e-10	-0.95	0.20	0.80	FALSE
61	Liver	N4bp2l2	alternative polyA	ENSRNOT00000118063	0.10	0.04	blup	681	0.07	1.5e-08	-6.1415	-6.4	1.5e-10	0.95	0.20	0.80	FALSE
62	Liver	Mcoln1	gene expression	ENSRNOG00000000975	0.09	0.04	lasso	39	0.04	1.7e-05	-5.6523	5.7	9.9e-09	-0.82	0.26	0.74	FALSE
63	Liver	Brca2	gene expression	ENSRNOG00000001111	0.04	0.02	top1	1	0.02	1.7e-03	-5.9210	5.9	3.2e-09	-0.57	0.03	0.06	FALSE
64	Liver	N4bp2l1	gene expression	ENSRNOG00000059322	0.21	0.13	enet	107	0.16	2.5e-17	-6.4320	-6.4	1.8e-10	0.74	0.05	0.95	FALSE
65	Liver	Stxbp2	isoform ratio	ENSRNOT00000107607	0.15	0.09	lasso	10	0.09	5.9e-10	-4.6181	-5.4	5.1e-08	0.71	0.61	0.39	FALSE
66	Liver	N4bp2l1	isoform ratio	ENSRNOT00000085295	0.07	0.05	top1	1	0.05	4.9e-06	-6.4821	-6.5	9.0e-11	0.85	0.01	0.96	FALSE
67	Liver	N4bp2l1	isoform ratio	ENSRNOT00000110394	0.06	0.03	blup	587	0.04	6.9e-05	-6.1415	6.2	4.7e-10	-0.94	0.15	0.85	FALSE
68	Liver	Insr	intron excision ratio	chr12:1257822:1307450	0.44	0.21	enet	94	0.21	3.2e-23	-5.8507	5.4	5.2e-08	-0.73	0.29	0.71	FALSE
69	Liver	Pet100	intron excision ratio	chr12:1680794:1680963	0.21	0.04	blup	1823	0.09	1.9e-10	-4.6885	-5.8	5.8e-09	0.85	0.59	0.41	FALSE
70	Liver	Zfp958	intron excision ratio	chr12:3953566:3958666	0.03	0.00	blup	1113	0.01	1.1e-02	-4.3617	-5.8	7.9e-09	0.76	0.26	0.27	FALSE
71	Liver	Zfp958	intron excision ratio	chr12:3953566:3967085	0.09	0.04	top1	1	0.04	1.5e-05	-6.0387	6.0	1.6e-09	-0.95	0.13	0.55	FALSE
72	Liver	Zfp958	intron excision ratio	chr12:3971128:3971331	0.07	0.03	top1	1	0.03	7.0e-04	-6.0884	6.1	1.1e-09	-0.89	0.05	0.20	TRUE
73	Liver	Zfp958	intron excision ratio	chr12:3971128:3973820	0.23	0.11	blup	1113	0.12	2.4e-13	-6.0884	-5.7	1.1e-08	0.95	0.26	0.74	FALSE
74	Liver	Zfp958	intron excision ratio	chr12:3971391:3973820	0.21	0.10	blup	1113	0.11	8.9e-12	-5.9384	5.7	1.1e-08	-0.95	0.26	0.74	FALSE
75	Liver	NA	intron excision ratio	chr12:3870992:3871195	0.09	0.04	top1	1	0.04	1.0e-05	-5.9299	5.9	3.0e-09	-0.95	0.14	0.34	FALSE
76	Liver	NA	intron excision ratio	chr12:3870992:3873703	0.18	0.10	top1	1	0.10	7.7e-11	-5.9475	-5.9	2.7e-09	0.95	0.26	0.74	FALSE
77	Liver	NA	intron excision ratio	chr12:3871255:3873703	0.14	0.09	top1	1	0.09	6.4e-10	-6.0884	6.1	1.1e-09	-0.95	0.13	0.87	FALSE
78	Liver	Elavl1	mRNA stability	ENSRNOG00000001069	0.16	0.05	lasso	4	0.05	3.3e-06	-5.8121	5.9	3.4e-09	-0.93	0.24	0.76	FALSE
79	Liver	N4bp2l2	mRNA stability	ENSRNOG00000001108	0.03	0.02	top1	1	0.02	2.0e-03	-6.3765	6.4	1.8e-10	-0.85	0.02	0.22	FALSE
80	Liver	Brca2	mRNA stability	ENSRNOG00000001111	0.15	0.07	top1	1	0.07	2.0e-08	-6.4821	6.5	9.0e-11	-0.89	0.01	0.99	TRUE
81	NAcc	Pet100	alternative TSS	ENSRNOT00000071928	0.08	0.03	top1	1	0.03	1.4e-03	-5.8575	5.9	4.7e-09	-0.78	0.08	0.19	TRUE
82	NAcc	Zfp958l1	gene expression	ENSRNOG00000000891	0.11	0.08	top1	1	0.08	1.6e-06	-5.9758	-6.0	2.3e-09	0.93	0.23	0.70	FALSE
83	NAcc	Rxfp2	gene expression	ENSRNOG00000000897	0.08	0.04	blup	3309	0.06	1.4e-05	-4.1564	-5.7	1.3e-08	0.79	0.88	0.11	FALSE
84	NAcc	Stxbp2	gene expression	ENSRNOG00000000994	0.10	0.07	top1	1	0.07	9.6e-06	-5.8575	-5.9	4.7e-09	0.81	0.11	0.42	FALSE
85	NAcc	Brca2	gene expression	ENSRNOG00000001111	0.27	0.18	enet	43	0.19	3.6e-14	-5.9834	6.1	1.4e-09	-0.97	0.11	0.89	FALSE
86	NAcc	Arhgef18	gene expression	ENSRNOG00000028090	0.13	0.05	blup	1531	0.08	1.3e-06	-4.3684	-5.8	8.5e-09	0.86	0.54	0.46	FALSE
87	NAcc	Lrrc8e	gene expression	ENSRNOG00000028460	0.31	0.06	lasso	12	0.07	1.2e-05	-5.7499	-5.8	6.2e-09	0.94	0.36	0.48	FALSE
88	NAcc	Insr	gene expression	ENSRNOG00000029986	0.80	0.33	lasso	50	0.36	1.5e-27	-5.7901	5.1	2.7e-07	-0.93	0.17	0.82	FALSE
89	NAcc	Trappc5	isoform ratio	ENSRNOT00000001327	0.11	0.04	lasso	38	0.04	2.9e-04	-5.8507	-6.0	1.9e-09	0.85	0.22	0.78	FALSE
90	NAcc	Trappc5	isoform ratio	ENSRNOT00000111016	0.09	0.02	lasso	29	0.03	5.1e-03	-5.8507	5.9	3.9e-09	-0.81	0.23	0.74	FALSE
91	NAcc	Zfp958	intron excision ratio	chr12:3971128:3973820	0.07	0.05	enet	10	0.05	1.1e-04	-6.0196	-5.3	9.7e-08	0.92	0.25	0.73	FALSE
92	NAcc	NA	intron excision ratio	chr12:3871255:3873703	0.06	0.05	top1	1	0.05	1.7e-04	-5.9420	5.9	2.8e-09	-0.96	0.06	0.11	FALSE
93	NAcc	Snapc2	mRNA stability	ENSRNOG00000001056	0.13	0.07	top1	1	0.06	1.3e-05	-5.5778	-5.6	2.4e-08	0.73	0.25	0.16	FALSE
94	NAcc	Brca2	mRNA stability	ENSRNOG00000001111	0.14	0.09	lasso	42	0.09	4.2e-07	-6.0544	6.2	6.8e-10	-0.80	0.08	0.92	FALSE
95	NAcc	Insr	mRNA stability	ENSRNOG00000029986	0.37	0.23	lasso	29	0.23	1.8e-17	-5.8507	5.6	2.4e-08	-0.74	0.33	0.67	TRUE
96	OFC	Stxbp2	gene expression	ENSRNOG00000000994	0.43	0.14	top1	1	0.14	2.8e-04	-5.7730	-5.8	7.8e-09	0.68	0.10	0.07	FALSE
97	OFC	Snapc2	gene expression	ENSRNOG00000001056	0.54	0.04	blup	2272	0.12	1.0e-03	-3.5888	-5.1	3.0e-07	0.61	0.50	0.06	FALSE
98	OFC	Insr	intron excision ratio	chr12:1257822:1307450	0.64	0.28	top1	1	0.28	2.2e-07	-5.8156	5.8	6.0e-09	-0.68	0.21	0.47	FALSE
99	OFC	Insr	mRNA stability	ENSRNOG00000029986	0.82	0.37	top1	1	0.37	1.0e-09	-5.7736	5.8	7.8e-09	-0.68	0.30	0.59	FALSE
100	PL	Stard13	gene expression	ENSRNOG00000001090	0.09	0.04	blup	1438	0.05	6.0e-05	-5.9893	5.1	2.7e-07	-0.91	0.24	0.74	TRUE
101	PL	Brca2	gene expression	ENSRNOG00000001111	0.44	0.26	lasso	11	0.31	6.0e-24	-5.9834	5.4	8.3e-08	-0.94	0.10	0.90	FALSE
102	PL	Pet100	intron excision ratio	chr12:1679962:1680708	0.08	0.03	top1	1	0.03	3.6e-03	-5.9125	-5.9	3.4e-09	0.68	0.07	0.19	FALSE
103	PL	Pet100	intron excision ratio	chr12:1680171:1680708	0.09	0.03	top1	1	0.03	1.3e-03	-5.8326	5.8	5.5e-09	-0.71	0.08	0.14	TRUE
104	PL	Pet100	intron excision ratio	chr12:1680794:1680963	0.49	0.13	blup	1822	0.18	2.5e-13	-5.3451	-6.0	1.8e-09	0.91	0.16	0.84	FALSE
105	PL	N4bp2l2	mRNA stability	ENSRNOG00000001108	0.05	0.04	top1	1	0.04	2.7e-04	-5.7573	-5.8	8.5e-09	0.95	0.04	0.04	FALSE
106	PL	Brca2	mRNA stability	ENSRNOG00000001111	0.19	0.12	lasso	14	0.13	7.3e-10	-5.9834	6.0	2.2e-09	-0.98	0.12	0.88	FALSE
107	PL	Insr	mRNA stability	ENSRNOG00000029986	0.65	0.46	lasso	32	0.49	2.3e-42	-5.8507	5.4	5.4e-08	-0.70	0.34	0.66	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.