Best TWAS P=9.05e-11 · Best GWAS P=5.52e-11 conditioned to 1.00e+00
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | N4bp2l2 | alternative polyA | ENSRNOT00000111844 | 0.14 | 1 | 0.12 | 7.1e-13 | 6.11 | 9.84e-10 | 0.83 | FALSE |
Adipose | N4bp2l2 | alternative polyA | ENSRNOT00000118063 | 0.14 | 1 | 0.12 | 3.9e-13 | -6.11 | 9.84e-10 | 0.83 | FALSE |
Adipose | B3glct | alternative polyA | ENSRNOT00000083484 | 0.06 | 19 | 0.03 | 2.4e-04 | 5.1 | 3.44e-07 | 0.02 | FALSE |
Adipose | B3glct | alternative polyA | ENSRNOT00000116254 | 0.06 | 18 | 0.03 | 1.9e-04 | -5.3 | 1.13e-07 | 0.02 | TRUE |
Adipose | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.22 | 116 | 0.13 | 3.4e-14 | 5.53 | 3.25e-08 | 0.56 | FALSE |
Adipose | Pet100 | alternative TSS | ENSRNOT00000107172 | 0.22 | 122 | 0.13 | 2.6e-14 | -5.54 | 3.00e-08 | 0.54 | FALSE |
Adipose | Xab2 | gene expression | ENSRNOG00000000988 | 0.14 | 1 | 0.05 | 2.2e-06 | -5.92 | 3.19e-09 | 0.86 | FALSE |
Adipose | Trappc5 | gene expression | ENSRNOG00000001003 | 0.09 | 1 | 0.03 | 9.9e-05 | -5.85 | 4.90e-09 | 0.29 | FALSE |
Adipose | Evi5l | gene expression | ENSRNOG00000001034 | 0.09 | 1 | -0 | 4.2e-01 | 5.64 | 1.73e-08 | 0.03 | TRUE |
Adipose | Insr | gene expression | ENSRNOG00000029986 | 0.13 | 1 | 0.02 | 4.3e-03 | 6 | 1.97e-09 | 0.06 | FALSE |
Adipose | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.32 | 16 | 0.24 | 1.2e-26 | -6.36 | 2.08e-10 | 0.92 | FALSE |
Adipose | Timm44 | isoform ratio | ENSRNOT00000096445 | 0.08 | 152 | 0.01 | 3.5e-02 | 5.5 | 3.81e-08 | 0.36 | FALSE |
Adipose | Timm44 | isoform ratio | ENSRNOT00000098717 | 0.08 | 173 | 0 | 1.2e-01 | -5.51 | 3.66e-08 | 0.32 | FALSE |
Adipose | N4bp2l2 | isoform ratio | ENSRNOT00000001468 | 0.05 | 681 | 0.02 | 6.1e-03 | 5.3 | 1.15e-07 | 0.65 | TRUE |
Adipose | Pet100 | isoform ratio | ENSRNOT00000071928 | 0.23 | 64 | 0.13 | 1.8e-14 | 5.55 | 2.94e-08 | 0.65 | FALSE |
Adipose | Pet100 | isoform ratio | ENSRNOT00000107172 | 0.23 | 66 | 0.13 | 2.6e-14 | -5.58 | 2.34e-08 | 0.66 | FALSE |
Adipose | Zfp958 | isoform ratio | ENSRNOT00000102786 | 0.03 | 169 | 0.01 | 6.9e-03 | 6.1 | 1.08e-09 | 0.46 | TRUE |
Adipose | Zfp958 | intron excision ratio | chr12:3971128:3971331 | 0.03 | 1113 | 0.01 | 2.8e-02 | 6 | 2.02e-09 | 0.39 | FALSE |
Adipose | Zfp958 | intron excision ratio | chr12:3971128:3973820 | 0.04 | 1113 | 0.02 | 5.3e-03 | -5.56 | 2.64e-08 | 0.54 | FALSE |
Adipose | Fry | mRNA stability | ENSRNOG00000000894 | 0.08 | 2970 | 0.05 | 2.0e-06 | -5.39 | 6.94e-08 | 0 | FALSE |
Adipose | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.11 | 19 | 0.01 | 5.0e-02 | -6.02 | 1.78e-09 | 0.04 | FALSE |
Adipose | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.16 | 2406 | 0.07 | 9.4e-09 | 6.01 | 1.88e-09 | 0.76 | FALSE |
BLA | Pet100 | alternative TSS | ENSRNOT00000110166 | 0.11 | 1 | 0.05 | 7.7e-04 | -5.88 | 4.11e-09 | 0.07 | TRUE |
BLA | Stard13 | gene expression | ENSRNOG00000001090 | 0.17 | 1 | 0.13 | 2.4e-07 | 5.93 | 3.06e-09 | 0.64 | FALSE |
BLA | Brca2 | gene expression | ENSRNOG00000001111 | 0.36 | 1 | 0.24 | 5.4e-13 | 5.96 | 2.51e-09 | 0.76 | FALSE |
BLA | Insr | gene expression | ENSRNOG00000029986 | 0.59 | 1546 | 0.39 | 5.5e-22 | 6.06 | 1.40e-09 | 0.82 | FALSE |
BLA | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.13 | 1 | 0.08 | 5.7e-05 | -5.92 | 3.20e-09 | 0.23 | FALSE |
BLA | Camsap3 | isoform ratio | ENSRNOT00000096347 | 0.13 | 20 | 0.03 | 9.2e-03 | -5.78 | 7.63e-09 | 0.81 | FALSE |
BLA | Camsap3 | isoform ratio | ENSRNOT00000101379 | 0.13 | 1 | 0.06 | 4.4e-04 | 5.88 | 4.11e-09 | 0.09 | FALSE |
BLA | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.36 | 13 | 0.19 | 1.7e-10 | -5.8 | 6.72e-09 | 0.72 | FALSE |
BLA | Pet100 | intron excision ratio | chr12:1680995:1681508 | 0.35 | 11 | 0.2 | 9.8e-11 | 5.63 | 1.82e-08 | 0.71 | FALSE |
BLA | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.08 | 1116 | 0.04 | 3.3e-03 | -6 | 1.93e-09 | 0.65 | FALSE |
BLA | Cers4 | mRNA stability | ENSRNOG00000001072 | 0.16 | 2109 | 0.08 | 5.0e-05 | 5.69 | 1.25e-08 | 0.67 | FALSE |
BLA | Stard13 | mRNA stability | ENSRNOG00000001090 | 0.08 | 1438 | 0.05 | 1.3e-03 | 5.41 | 6.41e-08 | 0.32 | FALSE |
BLA | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.19 | 1 | 0.12 | 9.3e-07 | 5.96 | 2.51e-09 | 0.7 | FALSE |
Brain | Zfp958 | alternative TSS | ENSRNOT00000103468 | 0.17 | 1115 | 0.13 | 7.5e-12 | 5.52 | 3.36e-08 | 0.01 | TRUE |
Brain | Zfp958 | alternative TSS | ENSRNOT00000104360 | 0.17 | 14 | 0.13 | 1.0e-11 | -5.16 | 2.51e-07 | 0.01 | FALSE |
Brain | ENSRNOG00000068541 | alternative TSS | ENSRNOT00000115928 | 0.08 | 60 | 0.05 | 1.4e-05 | 5.21 | 1.93e-07 | 0.23 | FALSE |
Brain | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.13 | 3311 | 0.12 | 3.5e-11 | -5.87 | 4.28e-09 | 0.02 | FALSE |
Brain | Elavl1 | gene expression | ENSRNOG00000001069 | 0.07 | 2406 | 0.02 | 4.4e-03 | -5.92 | 3.27e-09 | 0.64 | FALSE |
Brain | Brca2 | gene expression | ENSRNOG00000001111 | 0.42 | 21 | 0.33 | 6.8e-31 | 6.14 | 8.26e-10 | 0.85 | FALSE |
Brain | Arhgef18 | gene expression | ENSRNOG00000028090 | 0.12 | 11 | 0.08 | 1.2e-07 | -6.19 | 6.08e-10 | 0.78 | FALSE |
Brain | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.06 | 2 | 0.05 | 3.5e-05 | -6.38 | 1.82e-10 | 0.92 | FALSE |
Brain | Rxfp2 | intron excision ratio | chr12:4945988:4950591 | 0.07 | 6 | 0.02 | 7.0e-03 | -5.45 | 4.97e-08 | 0.02 | TRUE |
Brain | Rxfp2 | intron excision ratio | chr12:4945988:4950702 | 0.05 | 5 | 0.02 | 7.8e-03 | 5.38 | 7.28e-08 | 0.03 | FALSE |
Brain | Trappc5 | intron excision ratio | chr12:1737769:1740114 | 0.05 | 18 | 0.03 | 5.1e-04 | -6.26 | 3.77e-10 | 0.36 | FALSE |
Brain | Zfp958 | intron excision ratio | chr12:3971128:3973820 | 0.21 | 38 | 0.16 | 4.9e-15 | -5.44 | 5.41e-08 | 0.74 | FALSE |
Brain | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.13 | 14 | 0.1 | 1.0e-09 | -5.95 | 2.73e-09 | 0.74 | FALSE |
Brain | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.19 | 22 | 0.07 | 2.6e-07 | 5.92 | 3.21e-09 | 0.73 | FALSE |
Brain | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.29 | 14 | 0.18 | 3.2e-16 | 6.2 | 5.76e-10 | 0.85 | FALSE |
Brain | Insr | mRNA stability | ENSRNOG00000029986 | 0.72 | 150 | 0.6 | 8.8e-69 | 5.19 | 2.15e-07 | 0.66 | FALSE |
Eye | Fry | gene expression | ENSRNOG00000000894 | 0.41 | 2972 | 0.18 | 9.6e-04 | -5.44 | 5.39e-08 | 0.07 | FALSE |
Eye | Elavl1 | intron excision ratio | chr12:2667464:2684652 | 0.69 | 30 | 0.31 | 1.3e-05 | 6 | 1.99e-09 | 0.6 | FALSE |
IL | Zfp958l1 | alternative TSS | ENSRNOT00000035992 | 0.2 | 1 | 0 | 2.5e-01 | 6.01 | 1.89e-09 | 0.06 | FALSE |
IL | Zfp958l1 | alternative TSS | ENSRNOT00000119165 | 0.19 | 1 | 0.02 | 1.3e-01 | -6.01 | 1.89e-09 | 0.06 | FALSE |
IL | Insr | intron excision ratio | chr12:1257822:1307450 | 0.73 | 1 | 0.5 | 6.5e-14 | 5.82 | 6.04e-09 | 0.71 | FALSE |
IL | Pds5b | mRNA stability | ENSRNOG00000001098 | 0.19 | 795 | 0.11 | 1.5e-03 | 5.24 | 1.58e-07 | 0.34 | FALSE |
LHb | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.19 | 1 | 0.12 | 9.6e-04 | 6.14 | 8.23e-10 | 0.09 | FALSE |
Liver | N4bp2l2 | alternative polyA | ENSRNOT00000111844 | 0.06 | 1 | 0.02 | 1.5e-03 | 6.48 | 9.05e-11 | 0.36 | TRUE |
Liver | N4bp2l2 | alternative polyA | ENSRNOT00000111844 | 0.1 | 681 | 0.07 | 2.3e-08 | 6.41 | 1.45e-10 | 0.8 | FALSE |
Liver | N4bp2l2 | alternative polyA | ENSRNOT00000118063 | 0.1 | 681 | 0.07 | 1.5e-08 | -6.41 | 1.46e-10 | 0.8 | FALSE |
Liver | Mcoln1 | gene expression | ENSRNOG00000000975 | 0.09 | 39 | 0.04 | 1.7e-05 | 5.73 | 9.88e-09 | 0.74 | FALSE |
Liver | Brca2 | gene expression | ENSRNOG00000001111 | 0.04 | 1 | 0.02 | 1.7e-03 | 5.92 | 3.20e-09 | 0.06 | FALSE |
Liver | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.21 | 107 | 0.16 | 2.5e-17 | -6.38 | 1.77e-10 | 0.95 | FALSE |
Liver | Stxbp2 | isoform ratio | ENSRNOT00000107607 | 0.15 | 10 | 0.09 | 5.9e-10 | -5.45 | 5.14e-08 | 0.39 | FALSE |
Liver | N4bp2l1 | isoform ratio | ENSRNOT00000085295 | 0.07 | 1 | 0.05 | 4.9e-06 | -6.48 | 9.05e-11 | 0.96 | FALSE |
Liver | N4bp2l1 | isoform ratio | ENSRNOT00000110394 | 0.06 | 587 | 0.04 | 6.9e-05 | 6.23 | 4.65e-10 | 0.85 | FALSE |
Liver | Insr | intron excision ratio | chr12:1257822:1307450 | 0.44 | 94 | 0.21 | 3.2e-23 | 5.44 | 5.21e-08 | 0.71 | FALSE |
Liver | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.21 | 1823 | 0.09 | 1.9e-10 | -5.82 | 5.78e-09 | 0.41 | FALSE |
Liver | Zfp958 | intron excision ratio | chr12:3953566:3958666 | 0.03 | 1113 | 0.01 | 1.1e-02 | -5.77 | 7.86e-09 | 0.27 | FALSE |
Liver | Zfp958 | intron excision ratio | chr12:3953566:3967085 | 0.09 | 1 | 0.04 | 1.5e-05 | 6.04 | 1.55e-09 | 0.55 | FALSE |
Liver | Zfp958 | intron excision ratio | chr12:3971128:3971331 | 0.07 | 1 | 0.03 | 7.0e-04 | 6.09 | 1.14e-09 | 0.2 | TRUE |
Liver | Zfp958 | intron excision ratio | chr12:3971128:3973820 | 0.23 | 1113 | 0.12 | 2.4e-13 | -5.71 | 1.15e-08 | 0.74 | FALSE |
Liver | Zfp958 | intron excision ratio | chr12:3971391:3973820 | 0.21 | 1113 | 0.11 | 8.9e-12 | 5.72 | 1.08e-08 | 0.74 | FALSE |
Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3871195 | 0.09 | 1 | 0.04 | 1.0e-05 | 5.93 | 3.03e-09 | 0.34 | FALSE |
Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.18 | 1 | 0.1 | 7.7e-11 | -5.95 | 2.72e-09 | 0.74 | FALSE |
Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3871255:3873703 | 0.14 | 1 | 0.09 | 6.4e-10 | 6.09 | 1.14e-09 | 0.87 | FALSE |
Liver | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.16 | 4 | 0.05 | 3.3e-06 | 5.91 | 3.41e-09 | 0.76 | FALSE |
Liver | N4bp2l2 | mRNA stability | ENSRNOG00000001108 | 0.03 | 1 | 0.02 | 2.0e-03 | 6.38 | 1.81e-10 | 0.22 | FALSE |
Liver | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.15 | 1 | 0.07 | 2.0e-08 | 6.48 | 9.05e-11 | 0.99 | TRUE |
NAcc | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.08 | 1 | 0.03 | 1.4e-03 | 5.86 | 4.70e-09 | 0.19 | TRUE |
NAcc | Zfp958l1 | gene expression | ENSRNOG00000000891 | 0.11 | 1 | 0.08 | 1.6e-06 | -5.98 | 2.29e-09 | 0.7 | FALSE |
NAcc | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.08 | 3309 | 0.06 | 1.4e-05 | -5.68 | 1.35e-08 | 0.11 | FALSE |
NAcc | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.1 | 1 | 0.07 | 9.6e-06 | -5.86 | 4.70e-09 | 0.42 | FALSE |
NAcc | Brca2 | gene expression | ENSRNOG00000001111 | 0.27 | 43 | 0.19 | 3.6e-14 | 6.06 | 1.40e-09 | 0.89 | FALSE |
NAcc | Arhgef18 | gene expression | ENSRNOG00000028090 | 0.13 | 1531 | 0.08 | 1.3e-06 | -5.76 | 8.45e-09 | 0.46 | FALSE |
NAcc | Lrrc8e | gene expression | ENSRNOG00000028460 | 0.31 | 12 | 0.07 | 1.2e-05 | -5.81 | 6.21e-09 | 0.48 | FALSE |
NAcc | Insr | gene expression | ENSRNOG00000029986 | 0.8 | 50 | 0.36 | 1.5e-27 | 5.15 | 2.66e-07 | 0.82 | FALSE |
NAcc | Trappc5 | isoform ratio | ENSRNOT00000001327 | 0.11 | 38 | 0.04 | 2.9e-04 | -6.01 | 1.89e-09 | 0.78 | FALSE |
NAcc | Trappc5 | isoform ratio | ENSRNOT00000111016 | 0.09 | 29 | 0.03 | 5.1e-03 | 5.89 | 3.93e-09 | 0.74 | FALSE |
NAcc | Zfp958 | intron excision ratio | chr12:3971128:3973820 | 0.07 | 10 | 0.05 | 1.1e-04 | -5.33 | 9.66e-08 | 0.73 | FALSE |
NAcc | ENSRNOG00000068541 | intron excision ratio | chr12:3871255:3873703 | 0.06 | 1 | 0.05 | 1.7e-04 | 5.94 | 2.82e-09 | 0.11 | FALSE |
NAcc | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.13 | 1 | 0.06 | 1.3e-05 | -5.58 | 2.44e-08 | 0.16 | FALSE |
NAcc | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.14 | 42 | 0.09 | 4.2e-07 | 6.17 | 6.80e-10 | 0.92 | FALSE |
NAcc | Insr | mRNA stability | ENSRNOG00000029986 | 0.37 | 29 | 0.23 | 1.8e-17 | 5.58 | 2.38e-08 | 0.67 | TRUE |
OFC | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.43 | 1 | 0.14 | 2.8e-04 | -5.77 | 7.79e-09 | 0.07 | FALSE |
OFC | Snapc2 | gene expression | ENSRNOG00000001056 | 0.54 | 2272 | 0.12 | 1.0e-03 | -5.13 | 2.97e-07 | 0.06 | FALSE |
OFC | Insr | intron excision ratio | chr12:1257822:1307450 | 0.64 | 1 | 0.28 | 2.2e-07 | 5.82 | 6.04e-09 | 0.47 | FALSE |
OFC | Insr | mRNA stability | ENSRNOG00000029986 | 0.82 | 1 | 0.37 | 1.0e-09 | 5.77 | 7.76e-09 | 0.59 | FALSE |
PL | Stard13 | gene expression | ENSRNOG00000001090 | 0.09 | 1438 | 0.05 | 6.0e-05 | 5.15 | 2.66e-07 | 0.74 | TRUE |
PL | Brca2 | gene expression | ENSRNOG00000001111 | 0.44 | 11 | 0.31 | 6.0e-24 | 5.36 | 8.32e-08 | 0.9 | FALSE |
PL | Pet100 | intron excision ratio | chr12:1679962:1680708 | 0.08 | 1 | 0.03 | 3.6e-03 | -5.91 | 3.37e-09 | 0.19 | FALSE |
PL | Pet100 | intron excision ratio | chr12:1680171:1680708 | 0.09 | 1 | 0.03 | 1.3e-03 | 5.83 | 5.46e-09 | 0.14 | TRUE |
PL | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.49 | 1822 | 0.18 | 2.5e-13 | -6.02 | 1.75e-09 | 0.84 | FALSE |
PL | N4bp2l2 | mRNA stability | ENSRNOG00000001108 | 0.05 | 1 | 0.04 | 2.7e-04 | -5.76 | 8.55e-09 | 0.04 | FALSE |
PL | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.19 | 14 | 0.13 | 7.3e-10 | 5.98 | 2.18e-09 | 0.88 | FALSE |
PL | Insr | mRNA stability | ENSRNOG00000029986 | 0.65 | 32 | 0.49 | 2.3e-42 | 5.44 | 5.35e-08 | 0.66 | FALSE |