Best TWAS P=1.436553e-08 · Best GWAS P=7.603207e-08 conditioned to 0.4063404
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | AABR07029596.1 | alternative TSS | ENSRNOT00000058907 | 0.05 | 0.04 | top1 | 1 | 0.04 | 1.9e-05 | 5.3 | 5.3 | 1.1e-07 | 0.97 | 0.03 | 0.83 | FALSE |
| 2 | Adipose | AABR07029596.1 | alternative TSS | ENSRNOT00000114988 | 0.05 | 0.04 | top1 | 1 | 0.04 | 2.0e-05 | 5.3 | -5.3 | 1.1e-07 | -0.97 | 0.03 | 0.83 | FALSE |
| 3 | Adipose | AABR07029596.1 | isoform ratio | ENSRNOT00000058907 | 0.03 | 0.03 | top1 | 1 | 0.03 | 5.0e-04 | 5.2 | 5.2 | 2.0e-07 | 0.97 | 0.03 | 0.30 | FALSE |
| 4 | Adipose | AABR07029596.1 | isoform ratio | ENSRNOT00000114988 | 0.03 | 0.02 | lasso | 7 | 0.03 | 7.3e-04 | 5.2 | -5.2 | 2.0e-07 | -0.98 | 0.24 | 0.64 | FALSE |
| 5 | BLA | Septin8 | intron excision ratio | chr10:37701775:37712417 | 0.06 | 0.04 | enet | 14 | 0.05 | 1.8e-03 | 5.3 | 5.2 | 2.1e-07 | 0.99 | 0.22 | 0.65 | FALSE |
| 6 | BLA | Shroom1 | mRNA stability | ENSRNOG00000007431 | 0.18 | 0.05 | top1 | 1 | 0.05 | 8.2e-04 | 5.3 | 5.3 | 1.2e-07 | 0.93 | 0.03 | 0.35 | FALSE |
| 7 | Brain | Aff4 | mRNA stability | ENSRNOG00000006965 | 0.06 | 0.00 | enet | 26 | 0.01 | 4.4e-02 | 4.9 | 5.7 | 1.4e-08 | 0.88 | 0.26 | 0.62 | TRUE |
| 8 | Liver | AABR07029596.1 | gene expression | ENSRNOG00000046195 | 0.05 | 0.02 | top1 | 1 | 0.02 | 1.4e-03 | 5.3 | -5.3 | 1.2e-07 | -0.97 | 0.02 | 0.34 | FALSE |
| 9 | Liver | NA | gene expression | ENSRNOG00000069239 | 0.02 | 0.01 | top1 | 1 | 0.01 | 2.0e-02 | 5.3 | -5.3 | 1.2e-07 | -0.98 | 0.02 | 0.07 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.