Best TWAS P = 1.61e-08 · Best GWAS P= 1.45e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Usp36 | gene expression | Usp36 | 0.08 | 1 | 0.03 | 1.7e-04 | -5.65 | 1.65e-08 | 0.29 | FALSE |
| Adipose | C1qtnf1 | intron excision ratio | chr10_104174326_104176952 | 0.06 | 1 | 0.01 | 2.3e-02 | 5.52 | 3.48e-08 | 0.09 | FALSE |
| BLA | Usp36 | isoform ratio | XM_039086201.1 | 0.31 | 1 | 0.15 | 2.4e-08 | 5.25 | 1.54e-07 | 0.48 | FALSE |
| BLA | Usp36 | isoform ratio | XM_039086203.1 | 0.37 | 1975 | 0.16 | 1.3e-08 | 5.59 | 2.32e-08 | 0.24 | FALSE |
| Brain | Cyth1 | alternative TSS | NM_053910.1 | 0.22 | 79 | 0.04 | 2.9e-04 | 5.27 | 1.35e-07 | 0.14 | FALSE |
| Brain | Cyth1 | alternative TSS | XM_006247785.5 | 0.2 | 70 | 0.03 | 4.3e-04 | -5.27 | 1.37e-07 | 0.14 | TRUE |
| Brain | Usp36 | gene expression | Usp36 | 0.06 | 1 | 0.03 | 9.6e-04 | -5.46 | 4.71e-08 | 0.07 | TRUE |
| Brain | Usp36 | isoform ratio | XM_039086201.1 | 0.36 | 26 | 0.28 | 3.3e-26 | -5.6 | 2.19e-08 | 0.48 | FALSE |
| Brain | Usp36 | isoform ratio | XM_039086203.1 | 0.34 | 30 | 0.28 | 1.7e-26 | 5.65 | 1.61e-08 | 0.27 | TRUE |
| Brain | LOC134480909 | mRNA stability | LOC134480909 | 0.05 | 1 | 0.03 | 9.2e-04 | -5.46 | 4.71e-08 | 0.17 | FALSE |
| IL | Timp2 | gene expression | Timp2 | 0.42 | 1 | 0.15 | 1.9e-04 | -5.56 | 2.63e-08 | 0.08 | TRUE |
| LHb | Usp36 | gene expression | Usp36 | 0.31 | 17 | 0.13 | 6.7e-04 | 5.24 | 1.65e-07 | 0.68 | TRUE |
| NAcc | Timp2 | alternative polyA | XM_039085773.2 | 0.07 | 26 | 0.03 | 6.0e-06 | 5.48 | 4.24e-08 | 0.27 | FALSE |
| NAcc | Timp2 | gene expression | Timp2 | 0.11 | 48 | 0.06 | 1.2e-09 | -5.6 | 2.12e-08 | 0.84 | FALSE |
| PL | Usp36 | isoform ratio | XM_039086201.1 | 0.19 | 16 | 0.1 | 7.0e-11 | 5.52 | 3.30e-08 | 0.19 | FALSE |
| PL | Usp36 | isoform ratio | XM_039086203.1 | 0.19 | 14 | 0.1 | 4.5e-11 | 5.4 | 6.77e-08 | 0.18 | FALSE |
| PL | Usp36 | intron excision ratio | chr10_104025183_104027203 | 0.04 | 1 | 0.03 | 2.6e-04 | 5.26 | 1.46e-07 | 0.07 | FALSE |
| pVTA | Timp2 | alternative polyA | NM_021989.3 | 0.08 | 1 | 0.05 | 5.1e-05 | 5.25 | 1.54e-07 | 0.26 | FALSE |
| pVTA | Timp2 | alternative polyA | XM_039085773.2 | 0.09 | 1 | 0.06 | 1.6e-05 | -5.25 | 1.54e-07 | 0.35 | FALSE |
| pVTA | Usp36 | isoform ratio | XM_039086201.1 | 0.11 | 1975 | 0.05 | 5.8e-05 | -5.62 | 1.87e-08 | 0.8 | FALSE |
| pVTA | Usp36 | isoform ratio | XM_039086203.1 | 0.12 | 1975 | 0.06 | 3.2e-05 | 5.6 | 2.18e-08 | 0.79 | FALSE |
| pVTA | Usp36 | intron excision ratio | chr10_104023450_104027203 | 0.12 | 1975 | 0.04 | 2.5e-04 | 5.42 | 5.85e-08 | 0.23 | FALSE |