Hub : Traits : dissection: UMAP 1 of all traits : ← →

chr3:105,063,132-108,052,408

Best TWAS P=6.859554e-08 · Best GWAS P=9.203324e-08 conditioned to 0.286555

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ivd	alternative polyA	ENSRNOT00000107497	0.19	0.10	enet	158	0.10	1.3e-11	4.6	-5.1	3.3e-07	-0.68	0.59	0.41	FALSE
2	Adipose	Ivd	alternative polyA	ENSRNOT00000013829	0.19	0.10	enet	177	0.10	2.5e-11	4.6	5.2	2.5e-07	0.73	0.60	0.40	FALSE
3	Adipose	NA	gene expression	ENSRNOG00000012290	0.11	0.04	enet	310	0.04	1.6e-05	5.1	-5.2	2.6e-07	-0.92	0.11	0.88	FALSE
4	BLA	Ehd4	gene expression	ENSRNOG00000007584	0.32	0.23	lasso	5	0.23	1.4e-12	4.8	-5.4	6.9e-08	-0.91	0.30	0.70	TRUE
5	Brain	Ehd4	gene expression	ENSRNOG00000007584	0.32	0.24	lasso	9	0.26	2.1e-24	5.2	-5.2	1.7e-07	-0.92	0.15	0.85	FALSE
6	Brain	Mapkbp1	mRNA stability	ENSRNOG00000007018	0.08	0.08	top1	1	0.08	3.9e-08	5.1	-5.1	2.9e-07	-0.93	0.22	0.78	FALSE
7	Brain	Ehd4	mRNA stability	ENSRNOG00000007584	0.10	0.10	top1	1	0.10	2.7e-09	5.2	-5.2	1.8e-07	-0.92	0.13	0.87	FALSE
8	Liver	Disp2	gene expression	ENSRNOG00000026787	0.04	0.03	top1	1	0.03	5.8e-04	5.2	-5.2	1.9e-07	-0.97	0.06	0.19	FALSE
9	NAcc2	Ganc	mRNA stability	ENSRNOG00000024563	0.08	0.04	lasso	2	0.04	3.6e-03	4.7	-5.1	2.8e-07	-0.86	0.27	0.48	FALSE
10	PL2	Sptbn5	intron excision ratio	chr3:107017537:107018049	0.12	0.07	top1	1	0.07	1.6e-04	5.1	-5.1	3.0e-07	-0.88	0.10	0.27	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.