Best TWAS P=1.304022e-08 · Best GWAS P=2.038489e-09 conditioned to 0.0002868406
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Snx13 | alternative TSS | ENSRNOT00000084661 | 0.02 | 0.00 | blup | 2147 | 0.00 | 0.14000 | -4.5 | 5.3 | 9.1e-08 | -0.78 | 0.33 | 0.30 | FALSE |
| 2 | IL | Twist1 | gene expression | ENSRNOG00000011101 | 0.20 | 0.09 | enet | 8 | 0.13 | 0.00048 | -5.2 | -5.7 | 1.3e-08 | 0.50 | 0.24 | 0.60 | TRUE |
| 3 | LHb | Hdac9 | alternative polyA | ENSRNOT00000098095 | 0.28 | 0.03 | blup | 2189 | 0.11 | 0.00140 | -3.2 | -5.2 | 1.5e-07 | 0.66 | 0.56 | 0.18 | FALSE |
| 4 | PL | Hdac9 | isoform ratio | ENSRNOT00000005521 | 0.06 | 0.02 | blup | 2191 | 0.03 | 0.00120 | 4.1 | 5.5 | 4.4e-08 | -0.63 | 0.72 | 0.09 | FALSE |
| 5 | PL | Hdac9 | isoform ratio | ENSRNOT00000098095 | 0.04 | 0.01 | blup | 2191 | 0.02 | 0.01200 | 4.1 | -5.4 | 8.5e-08 | 0.68 | 0.49 | 0.09 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.