Best TWAS P = 7.33e-13 · Best GWAS P= 1.21e-13 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Mars2 | alternative polyA | XM_003750699.6 | 0.02 | 1 | 0.03 | 8.6e-04 | -6.06 | 1.39e-09 | 0.03 | FALSE |
| Adipose | Sf3b1 | alternative polyA | NM_053426.1 | 0.05 | 1557 | 0.03 | 2.0e-04 | 6.77 | 1.31e-11 | 0.42 | FALSE |
| Adipose | Sf3b1 | alternative polyA | XM_017596654.2 | 0.05 | 1 | 0.03 | 3.0e-04 | -5.47 | 4.48e-08 | 0.02 | FALSE |
| Adipose | LOC120094685 | alternative TSS | XR_010054979.1 | 0.03 | 1 | 0.02 | 3.0e-03 | 6.19 | 6.15e-10 | 0.03 | FALSE |
| Adipose | Slc39a10 | alternative TSS | NM_001108796.2 | 0.02 | 1 | 0.01 | 9.7e-03 | -7.05 | 1.84e-12 | 0.14 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_006244936.5 | 0.04 | 1 | 0.04 | 2.0e-05 | 6.96 | 3.44e-12 | 0.62 | FALSE |
| Adipose | Coq10b | gene expression | Coq10b | 0.06 | 22 | 0.04 | 1.6e-05 | -6.98 | 3.04e-12 | 0.71 | FALSE |
| Adipose | Hspd1 | gene expression | Hspd1 | 0.03 | 1509 | 0.02 | 3.6e-03 | -5.25 | 1.54e-07 | 0.21 | FALSE |
| Adipose | LOC120094685 | gene expression | LOC120094685 | 0.1 | 1 | 0.1 | 5.4e-11 | 6.96 | 3.44e-12 | 0.92 | FALSE |
| Adipose | Pgap1 | gene expression | Pgap1 | 0.05 | 1 | 0.04 | 8.7e-06 | -7.14 | 9.43e-13 | 0.73 | FALSE |
| Adipose | Plcl1 | gene expression | Plcl1 | 0.03 | 1693 | 0.03 | 1.7e-04 | -5.5 | 3.80e-08 | 0.23 | FALSE |
| Adipose | Slc39a10 | gene expression | Slc39a10 | 0.02 | 1 | 0.02 | 6.2e-03 | -6.96 | 3.44e-12 | 0.05 | FALSE |
| Adipose | Stk17b | gene expression | Stk17b | 0.03 | 1749 | 0.01 | 6.7e-03 | 6.81 | 9.51e-12 | 0.44 | FALSE |
| Adipose | Boll | isoform ratio | XM_039084087.2 | 0.03 | 1707 | 0.03 | 2.7e-04 | -5.81 | 6.32e-09 | 0.24 | FALSE |
| Adipose | Hecw2 | isoform ratio | XM_006244912.5 | 0.07 | 6 | 0.02 | 2.5e-03 | -6.72 | 1.78e-11 | 0.56 | FALSE |
| Adipose | Mars2 | isoform ratio | XM_003750699.6 | 0.16 | 7 | 0.13 | 1.3e-14 | -5.61 | 2.07e-08 | 0.15 | FALSE |
| Adipose | Mars2 | isoform ratio | XM_039084841.2 | 0.03 | 462 | 0.02 | 2.0e-03 | 5.21 | 1.86e-07 | 0.46 | FALSE |
| Adipose | Slc39a10 | isoform ratio | NM_001108796.2 | 0.02 | 1 | 0.01 | 9.7e-03 | -7.05 | 1.84e-12 | 0.14 | FALSE |
| Adipose | Gtf3c3 | intron excision ratio | chr9_63433184_63436242 | 0.02 | 1 | 0.02 | 1.5e-03 | -5.8 | 6.59e-09 | 0.03 | FALSE |
| Adipose | Hecw2 | intron excision ratio | chr9_62982726_62986764 | 0.03 | 2004 | 0.02 | 5.6e-03 | 6.37 | 1.94e-10 | 0.3 | FALSE |
| Adipose | Coq10b | mRNA stability | Coq10b | 0.02 | 1517 | 0.01 | 7.1e-03 | -6.58 | 4.78e-11 | 0.33 | FALSE |
| Adipose | Pgap1 | mRNA stability | Pgap1 | 0.15 | 21 | 0.14 | 9.5e-16 | -7 | 2.65e-12 | 0.17 | FALSE |
| BLA | Mars2 | alternative polyA | XM_039084841.2 | 0.08 | 70 | 0.02 | 2.4e-02 | 5.98 | 2.22e-09 | 0.43 | FALSE |
| BLA | Sf3b1 | alternative polyA | NM_053426.1 | 0.21 | 1557 | 0.17 | 2.3e-09 | 6.99 | 2.73e-12 | 0.55 | FALSE |
| BLA | Sf3b1 | alternative polyA | XM_017596654.2 | 0.22 | 1557 | 0.17 | 1.7e-09 | -6.99 | 2.83e-12 | 0.54 | FALSE |
| BLA | Mars2 | isoform ratio | XM_003750699.6 | 0.21 | 1443 | 0.11 | 1.2e-06 | -6.97 | 3.07e-12 | 0.58 | FALSE |
| BLA | Sf3b1 | isoform ratio | XM_017596654.2 | 0.11 | 1 | 0.06 | 7.2e-04 | -6.35 | 2.14e-10 | 0.04 | FALSE |
| Brain | Gtf3c3 | alternative polyA | NM_001108239.1 | 0.09 | 154 | 0.06 | 1.8e-06 | 5.61 | 1.99e-08 | 0.17 | FALSE |
| Brain | Gtf3c3 | alternative polyA | NM_001108239.1 | 0.08 | 192 | 0.06 | 2.7e-06 | 5.58 | 2.43e-08 | 0.17 | FALSE |
| Brain | Mars2 | alternative polyA | XM_003750699.6 | 0.11 | 1443 | 0.13 | 6.8e-12 | -7.05 | 1.80e-12 | 0.6 | FALSE |
| Brain | Mars2 | alternative polyA | XM_039084841.2 | 0.03 | 1443 | 0.03 | 6.4e-04 | 6.91 | 4.70e-12 | 0.46 | FALSE |
| Brain | Sf3b1 | alternative polyA | NM_053426.1 | 0.34 | 1 | 0.29 | 8.9e-28 | 6.73 | 1.72e-11 | 0.38 | FALSE |
| Brain | Sf3b1 | alternative polyA | XM_017596654.2 | 0.35 | 1 | 0.29 | 9.8e-28 | -6.55 | 5.78e-11 | 0.16 | FALSE |
| Brain | Stk17b | alternative TSS | XM_039082991.2 | 0.02 | 1 | 0.03 | 3.6e-04 | -6.55 | 5.65e-11 | 0.03 | FALSE |
| Brain | C9h2orf66 | gene expression | C9h2orf66 | 0.07 | 1 | 0.07 | 7.6e-07 | 6.42 | 1.33e-10 | 0.07 | FALSE |
| Brain | Coq10b | gene expression | Coq10b | 0.14 | 531 | 0.14 | 2.7e-13 | -6.85 | 7.19e-12 | 0.81 | FALSE |
| Brain | LOC120094685 | gene expression | LOC120094685 | 0.13 | 1 | 0.08 | 4.2e-08 | 6.49 | 8.40e-11 | 0.35 | FALSE |
| Brain | Pgap1 | gene expression | Pgap1 | 0.23 | 1 | 0.25 | 8.1e-23 | -6.34 | 2.37e-10 | 0.06 | FALSE |
| Brain | Slc39a10 | gene expression | Slc39a10 | 0.04 | 1 | 0.02 | 2.5e-03 | -6.42 | 1.33e-10 | 0.03 | FALSE |
| Brain | Mars2 | isoform ratio | XM_003750699.6 | 0.18 | 18 | 0.21 | 1.2e-19 | -6.96 | 3.50e-12 | 0.63 | FALSE |
| Brain | Mars2 | isoform ratio | XM_039084841.2 | 0.05 | 1443 | 0.05 | 8.5e-06 | 7.03 | 2.05e-12 | 0.55 | FALSE |
| Brain | Sf3b1 | isoform ratio | NM_053426.1 | 0.13 | 44 | 0.08 | 5.1e-08 | 6.46 | 1.02e-10 | 0.31 | FALSE |
| Brain | Sf3b1 | isoform ratio | XM_017596654.2 | 0.09 | 1 | 0.08 | 7.7e-08 | -6.67 | 2.59e-11 | 0.27 | FALSE |
| Brain | Stk17b | isoform ratio | XM_039082991.2 | 0.03 | 1 | 0.02 | 5.9e-03 | -6.53 | 6.74e-11 | 0.03 | FALSE |
| Brain | Mars2 | mRNA stability | Mars2 | 0.04 | 1443 | 0.01 | 2.1e-02 | -6.37 | 1.89e-10 | 0.64 | FALSE |
| Brain | Pgap1 | mRNA stability | Pgap1 | 0.06 | 1 | 0.06 | 6.2e-06 | -6.42 | 1.35e-10 | 0.08 | FALSE |
| Brain | Plcl1 | mRNA stability | Plcl1 | 0.04 | 1693 | 0.03 | 1.6e-03 | 5.99 | 2.09e-09 | 0.36 | FALSE |
| IC | Mars2 | alternative polyA | XM_003750699.6 | 0.11 | 32 | 0.09 | 1.7e-04 | -6.87 | 6.24e-12 | 0.42 | FALSE |
| IC | Sf3b1 | alternative polyA | NM_053426.1 | 0.11 | 1 | 0.08 | 3.6e-04 | 6.55 | 5.78e-11 | 0.05 | FALSE |
| IC | Sf3b1 | alternative polyA | XM_017596654.2 | 0.11 | 1 | 0.09 | 9.2e-05 | -6.55 | 5.78e-11 | 0.05 | FALSE |
| IC | Coq10b | gene expression | Coq10b | 0.16 | 1517 | 0.08 | 4.4e-04 | -5.77 | 7.74e-09 | 0.65 | FALSE |
| IC | LOC120094685 | gene expression | LOC120094685 | 0.09 | 1957 | 0.09 | 1.1e-04 | 5.42 | 6.10e-08 | 0.08 | FALSE |
| IC | Pgap1 | gene expression | Pgap1 | 0.08 | 1899 | 0.05 | 3.6e-03 | -6.33 | 2.39e-10 | 0.4 | FALSE |
| IC | Mars2 | isoform ratio | XM_003750699.6 | 0.18 | 129 | 0.17 | 1.0e-07 | -7 | 2.52e-12 | 0.32 | FALSE |
| IL | Mars2 | alternative polyA | XM_003750699.6 | 0.18 | 1012 | 0.07 | 7.5e-03 | -6.95 | 3.72e-12 | 0.38 | FALSE |
| IL | Sf3b1 | alternative polyA | NM_053426.1 | 0.28 | 1 | 0.19 | 2.2e-05 | 7 | 2.49e-12 | 0.1 | FALSE |
| IL | Sf3b1 | alternative polyA | XM_017596654.2 | 0.28 | 1 | 0.19 | 2.2e-05 | -7 | 2.49e-12 | 0.1 | FALSE |
| IL | LOC120094685 | gene expression | LOC120094685 | 0.46 | 27 | 0.15 | 1.6e-04 | 7.04 | 1.90e-12 | 0.52 | FALSE |
| IL | Mars2 | isoform ratio | XM_003750699.6 | 0.19 | 1012 | 0.11 | 1.3e-03 | -6.87 | 6.41e-12 | 0.39 | FALSE |
| IL | LOC120094685 | intron excision ratio | chr9_62337994_62370408 | 0.19 | 1 | 0.06 | 1.5e-02 | 6.34 | 2.35e-10 | 0.05 | FALSE |
| IL | Slc39a10 | intron excision ratio | chr9_62370704_62423146 | 0.2 | 1 | 0.06 | 1.8e-02 | 6.3 | 2.98e-10 | 0.05 | FALSE |
| LHb | Mars2 | alternative polyA | XM_003750699.6 | 0.45 | 1012 | 0.15 | 2.1e-04 | -7.14 | 9.11e-13 | 0.58 | FALSE |
| LHb | Sf3b1 | alternative polyA | NM_053426.1 | 0.28 | 17 | 0.19 | 3.5e-05 | 6.98 | 3.04e-12 | 0.62 | FALSE |
| LHb | Sf3b1 | alternative polyA | XM_017596654.2 | 0.27 | 17 | 0.19 | 3.2e-05 | -6.98 | 3.04e-12 | 0.61 | FALSE |
| LHb | Coq10b | gene expression | Coq10b | 0.41 | 1 | 0.11 | 1.7e-03 | -7 | 2.49e-12 | 0.08 | FALSE |
| LHb | Mars2 | isoform ratio | XM_003750699.6 | 0.37 | 33 | 0.18 | 5.8e-05 | -7.1 | 1.28e-12 | 0.54 | FALSE |
| Liver | Mars2 | alternative polyA | XM_003750699.6 | 0.27 | 27 | 0.24 | 9.6e-27 | -6.7 | 2.09e-11 | 0.19 | FALSE |
| Liver | Mars2 | alternative polyA | XM_039084841.2 | 0.1 | 17 | 0.11 | 1.4e-12 | 6.55 | 5.78e-11 | 0.2 | FALSE |
| Liver | Ankrd44 | gene expression | Ankrd44 | 0.03 | 1 | 0.04 | 3.0e-05 | 6.55 | 5.78e-11 | 0.04 | FALSE |
| Liver | Ccdc150 | gene expression | Ccdc150 | 0.03 | 1 | 0.03 | 1.9e-04 | -6.55 | 5.78e-11 | 0.03 | FALSE |
| Liver | LOC108351932 | gene expression | LOC108351932 | 0.05 | 1 | 0.05 | 7.3e-06 | 6.55 | 5.78e-11 | 0.12 | FALSE |
| Liver | LOC120094685 | gene expression | LOC120094685 | 0.1 | 82 | 0.04 | 6.6e-05 | 6.93 | 4.35e-12 | 0.19 | FALSE |
| Liver | Mars2 | gene expression | Mars2 | 0.04 | 1 | 0.04 | 1.3e-05 | 5.92 | 3.24e-09 | 0.02 | FALSE |
| Liver | Slc39a10 | gene expression | Slc39a10 | 0.03 | 23 | 0.01 | 5.0e-02 | 6.97 | 3.12e-12 | 0.39 | FALSE |
| Liver | Mars2 | isoform ratio | XM_003750699.6 | 0.29 | 30 | 0.34 | 1.0e-38 | -6.69 | 2.24e-11 | 0.19 | FALSE |
| Liver | Mars2 | isoform ratio | XM_039084841.2 | 0.12 | 281 | 0.15 | 1.5e-16 | 6.63 | 3.47e-11 | 0.19 | FALSE |
| Liver | Hspd1 | mRNA stability | Hspd1 | 0.2 | 1 | 0.18 | 8.4e-20 | -6.98 | 3.05e-12 | 0.7 | FALSE |
| Liver | Pgap1 | mRNA stability | Pgap1 | 0.03 | 2 | 0.01 | 7.4e-03 | -7.03 | 2.11e-12 | 0.54 | FALSE |
| NAcc | Mars2 | alternative polyA | XM_003750699.6 | 0.12 | 1 | 0.08 | 1.2e-11 | -6.59 | 4.55e-11 | 0.08 | FALSE |
| NAcc | Sf3b1 | alternative polyA | NM_053426.1 | 0.15 | 1 | 0.08 | 7.2e-12 | 6.66 | 2.79e-11 | 0.28 | FALSE |
| NAcc | Sf3b1 | alternative polyA | XM_017596654.2 | 0.15 | 1 | 0.08 | 7.1e-12 | -6.66 | 2.79e-11 | 0.28 | FALSE |
| NAcc | Hecw2 | alternative TSS | NM_001108218.1 | 0.03 | 1 | 0.01 | 2.6e-02 | -6.29 | 3.26e-10 | 0.03 | FALSE |
| NAcc | Ccdc150 | gene expression | Ccdc150 | 0.03 | 1 | 0.01 | 4.0e-02 | -5.7 | 1.22e-08 | 0.03 | FALSE |
| NAcc | Coq10b | gene expression | Coq10b | 0.05 | 1 | 0.01 | 7.1e-03 | -7.01 | 2.35e-12 | 0.3 | FALSE |
| NAcc | Mob4 | gene expression | Mob4 | 0.03 | 1 | 0.01 | 9.4e-03 | -6.35 | 2.14e-10 | 0.03 | FALSE |
| NAcc | Pgap1 | gene expression | Pgap1 | 0.12 | 17 | 0.05 | 1.2e-08 | -5.72 | 1.06e-08 | 0.01 | FALSE |
| NAcc | Plcl1 | gene expression | Plcl1 | 0.02 | 1693 | 0.01 | 1.9e-02 | 5.64 | 1.66e-08 | 0.2 | FALSE |
| NAcc | Rftn2 | gene expression | Rftn2 | 0.04 | 1443 | 0.02 | 1.2e-03 | -5.62 | 1.87e-08 | 0.21 | FALSE |
| NAcc | Sf3b1 | gene expression | Sf3b1 | 0.03 | 1 | 0.01 | 3.2e-03 | 6.73 | 1.72e-11 | 0.03 | FALSE |
| NAcc | LOC120094685 | isoform ratio | XR_010054978.1 | 0.03 | 1 | 0.01 | 4.3e-02 | -6.97 | 3.16e-12 | 0.04 | FALSE |
| NAcc | Mars2 | isoform ratio | XM_003750699.6 | 0.15 | 1 | 0.09 | 4.8e-14 | -6.59 | 4.55e-11 | 0.08 | FALSE |
| NAcc | Hspd1 | mRNA stability | Hspd1 | 0.08 | 1509 | 0.04 | 2.2e-07 | -5.21 | 1.86e-07 | 0.74 | FALSE |
| OFC | Sf3b1 | alternative polyA | NM_053426.1 | 0.36 | 978 | 0.14 | 3.5e-04 | 6.73 | 1.72e-11 | 0.43 | FALSE |
| OFC | Sf3b1 | alternative polyA | XM_017596654.2 | 0.32 | 978 | 0.12 | 7.4e-04 | -6.75 | 1.50e-11 | 0.42 | FALSE |
| OFC | Ccdc150 | alternative TSS | XM_039083605.2 | 0.26 | 17 | 0.07 | 9.2e-03 | 6.92 | 4.40e-12 | 0.29 | FALSE |
| OFC | C9h2orf66 | gene expression | C9h2orf66 | 0.2 | 295 | 0.06 | 1.4e-02 | 6.11 | 9.78e-10 | 0.19 | FALSE |
| OFC | LOC120094685 | gene expression | LOC120094685 | 0.39 | 1 | 0.07 | 9.5e-03 | 6.45 | 1.09e-10 | 0.05 | FALSE |
| OFC | Mars2 | isoform ratio | XM_003750699.6 | 0.29 | 1 | 0.12 | 9.0e-04 | -7 | 2.49e-12 | 0.06 | FALSE |
| PL | Mars2 | alternative polyA | XM_003750699.6 | 0.08 | 1 | 0.07 | 3.2e-08 | -7 | 2.62e-12 | 0.58 | FALSE |
| PL | Sf3b1 | alternative polyA | NM_053426.1 | 0.29 | 67 | 0.21 | 1.4e-22 | 6.7 | 2.09e-11 | 0.26 | FALSE |
| PL | Sf3b1 | alternative polyA | XM_017596654.2 | 0.28 | 72 | 0.2 | 9.3e-22 | -6.69 | 2.17e-11 | 0.26 | FALSE |
| PL | LOC120094685 | alternative TSS | XR_010054979.1 | 0.03 | 1957 | 0.01 | 1.4e-02 | 6.48 | 9.13e-11 | 0.26 | FALSE |
| PL | Slc39a10 | alternative TSS | NM_001108796.2 | 0.03 | 1 | 0.02 | 6.7e-03 | -7.06 | 1.67e-12 | 0.1 | FALSE |
| PL | C9h2orf66 | gene expression | C9h2orf66 | 0.06 | 11 | 0.03 | 2.5e-04 | 6.06 | 1.36e-09 | 0.54 | FALSE |
| PL | Ccdc150 | gene expression | Ccdc150 | 0.05 | 1 | 0.03 | 5.1e-04 | -5.47 | 4.48e-08 | 0.03 | FALSE |
| PL | Coq10b | gene expression | Coq10b | 0.05 | 1 | 0.04 | 1.3e-05 | -6.98 | 2.88e-12 | 0.54 | FALSE |
| PL | LOC120094685 | gene expression | LOC120094685 | 0.22 | 1 | 0.23 | 1.3e-24 | 6.14 | 8.16e-10 | 0.06 | FALSE |
| PL | Pgap1 | gene expression | Pgap1 | 0.05 | 1 | 0.04 | 8.3e-05 | -6.28 | 3.32e-10 | 0.03 | FALSE |
| PL | Plcl1 | gene expression | Plcl1 | 0.03 | 1693 | 0.02 | 6.0e-03 | 6.36 | 2.07e-10 | 0.5 | FALSE |
| PL | Mars2 | isoform ratio | XM_003750699.6 | 0.15 | 1 | 0.14 | 2.1e-15 | -6.61 | 3.91e-11 | 0.09 | FALSE |
| PL | Sf3b1 | isoform ratio | XM_017596654.2 | 0.03 | 1 | 0.02 | 1.6e-03 | -6.65 | 2.90e-11 | 0.03 | FALSE |
| PL | Slc39a10 | intron excision ratio | chr9_62406020_62423146 | 0.03 | 2015 | 0.01 | 1.2e-02 | -6.44 | 1.23e-10 | 0.26 | FALSE |
| PL | Slc39a10 | mRNA stability | Slc39a10 | 0.15 | 34 | 0.07 | 1.8e-08 | -5.6 | 2.14e-08 | 0.47 | FALSE |
| pVTA | Mars2 | alternative polyA | XM_003750699.6 | 0.22 | 1443 | 0.16 | 1.5e-12 | -7.04 | 1.96e-12 | 0.23 | FALSE |
| pVTA | Mars2 | alternative polyA | XM_039084841.2 | 0.06 | 4 | 0.06 | 2.1e-05 | 6.84 | 7.80e-12 | 0.66 | FALSE |
| pVTA | Sf3b1 | alternative polyA | NM_053426.1 | 0.16 | 1 | 0.16 | 1.0e-12 | 6.55 | 5.78e-11 | 0.16 | FALSE |
| pVTA | Sf3b1 | alternative polyA | XM_017596654.2 | 0.16 | 1 | 0.16 | 1.2e-12 | -6.61 | 3.91e-11 | 0.22 | FALSE |
| pVTA | Gtf3c3 | alternative TSS | XM_063267350.1 | 0.03 | 21 | 0.03 | 3.3e-03 | 5.72 | 1.08e-08 | 0.22 | FALSE |
| pVTA | Coq10b | gene expression | Coq10b | 0.1 | 1 | 0.11 | 7.9e-09 | -7.01 | 2.46e-12 | 0.79 | FALSE |
| pVTA | LOC120094685 | gene expression | LOC120094685 | 0.08 | 1957 | 0.03 | 3.6e-03 | -5.45 | 4.94e-08 | 0.38 | FALSE |
| pVTA | Rftn2 | gene expression | Rftn2 | 0.03 | 1 | 0.03 | 2.7e-03 | -6.61 | 3.91e-11 | 0.03 | FALSE |
| pVTA | Mars2 | isoform ratio | XM_003750699.6 | 0.18 | 32 | 0.23 | 4.2e-18 | -7.05 | 1.76e-12 | 0.22 | FALSE |
| pVTA | Hspd1 | mRNA stability | Hspd1 | 0.09 | 1 | 0.09 | 6.6e-08 | -6.98 | 3.05e-12 | 0.69 | FALSE |
| pVTA | Slc39a10 | mRNA stability | Slc39a10 | 0.06 | 1 | 0.06 | 3.0e-05 | 6.01 | 1.86e-09 | 0.03 | FALSE |
| RMTg | Dnah7 | alternative TSS | NM_001419550.1 | 0.11 | 1 | 0.1 | 1.6e-03 | 6.29 | 3.22e-10 | 0.05 | FALSE |
| RMTg | C9h2orf66 | gene expression | C9h2orf66 | 0.17 | 18 | 0.04 | 3.5e-02 | 7.17 | 7.33e-13 | 0.37 | TRUE |