Best TWAS P=2.53e-12 · Best GWAS P=1.42e-12 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Mars2 | alternative polyA | XM_003750699.5 | 0.1 | 1 | 0.12 | 2.7e-13 | 5.39 | 6.92e-08 | 0 | FALSE |
| Adipose | Sf3b1 | alternative polyA | NM_053426.1 | 0.05 | 1 | 0.03 | 9.3e-05 | -5.45 | 5.08e-08 | 0.03 | FALSE |
| Adipose | Sf3b1 | alternative polyA | XM_017596654.2 | 0.05 | 1 | 0.04 | 6.0e-05 | 5.45 | 5.08e-08 | 0.03 | FALSE |
| Adipose | Hecw2 | alternative TSS | XM_006244912.4 | 0.08 | 1 | 0.03 | 1.1e-04 | 6.93 | 4.12e-12 | 0.21 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_039083855.1 | 0.04 | 1974 | 0.03 | 8.5e-04 | 6.06 | 1.35e-09 | 0.42 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_039083856.1 | 0.02 | 1 | 0.01 | 4.0e-02 | 5.95 | 2.75e-09 | 0.03 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_039083852.1 | 0.06 | 244 | 0.05 | 5.7e-06 | -5.56 | 2.76e-08 | 0.22 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_039083855.1 | 0.04 | 1974 | 0.03 | 8.6e-04 | 6.06 | 1.35e-09 | 0.42 | FALSE |
| Adipose | Slc39a10 | alternative TSS | XM_039083856.1 | 0.02 | 1 | 0.01 | 3.4e-02 | 5.95 | 2.75e-09 | 0.03 | FALSE |
| Adipose | Coq10b | gene expression | Coq10b | 0.05 | 1 | 0.04 | 1.4e-05 | 6.44 | 1.19e-10 | 0.63 | FALSE |
| Adipose | Hspd1 | gene expression | Hspd1 | 0.03 | 1 | 0.02 | 1.7e-03 | 5.5 | 3.84e-08 | 0.03 | FALSE |
| Adipose | Mars2 | gene expression | Mars2 | 0.03 | 1 | 0.03 | 1.8e-04 | -5.38 | 7.42e-08 | 0.03 | FALSE |
| Adipose | Pgap1 | gene expression | Pgap1 | 0.06 | 1 | 0.04 | 9.3e-06 | 6.4 | 1.54e-10 | 0.07 | FALSE |
| Adipose | Stk17b | gene expression | Stk17b | 0.03 | 1 | 0.02 | 4.8e-03 | -7 | 2.53e-12 | 0.08 | TRUE |
| Adipose | Hecw2 | isoform ratio | XM_006244912.4 | 0.08 | 1950 | 0.03 | 3.4e-04 | -5.59 | 2.22e-08 | 0.48 | FALSE |
| Adipose | Hecw2 | isoform ratio | XM_039083601.1 | 0.07 | 1 | 0.03 | 1.8e-04 | -6.92 | 4.57e-12 | 0.25 | FALSE |
| Adipose | Slc39a10 | isoform ratio | XM_039083856.1 | 0.03 | 1 | 0.01 | 1.1e-02 | 6.33 | 2.39e-10 | 0.06 | FALSE |
| Adipose | Hecw2 | intron excision ratio | chr9_55488290_55492328 | 0.03 | 1950 | 0.02 | 5.8e-03 | 5.8 | 6.63e-09 | 0.3 | FALSE |
| Adipose | Coq10b | mRNA stability | Coq10b | 0.02 | 1479 | 0.01 | 1.1e-02 | -5.41 | 6.31e-08 | 0.26 | FALSE |
| Adipose | Pgap1 | mRNA stability | Pgap1 | 0.16 | 27 | 0.14 | 1.5e-15 | -6.14 | 8.18e-10 | 0 | FALSE |
| BLA | Mars2 | alternative polyA | XM_039084841.1 | 0.06 | 1423 | 0.04 | 2.6e-03 | 6.01 | 1.89e-09 | 0.48 | FALSE |
| BLA | Sf3b1 | alternative polyA | NM_053426.1 | 0.22 | 293 | 0.19 | 1.4e-10 | -6.04 | 1.57e-09 | 0.43 | FALSE |
| BLA | Sf3b1 | alternative polyA | XM_017596654.2 | 0.21 | 200 | 0.2 | 1.0e-10 | 5.99 | 2.12e-09 | 0.42 | FALSE |
| BLA | Coq10b | gene expression | Coq10b | 0.06 | 1481 | 0.05 | 1.5e-03 | -6.5 | 8.11e-11 | 0.63 | FALSE |
| BLA | Coq10b | isoform ratio | NM_001009671.1 | 0.07 | 1 | 0.04 | 5.0e-03 | -6.35 | 2.21e-10 | 0.07 | FALSE |
| BLA | Coq10b | isoform ratio | XM_039083296.1 | 0.07 | 1 | 0.04 | 4.8e-03 | 6.45 | 1.13e-10 | 0.1 | FALSE |
| BLA | Mars2 | isoform ratio | XM_039084841.1 | 0.09 | 1423 | 0.07 | 1.9e-04 | 6.18 | 6.40e-10 | 0.57 | FALSE |
| Brain | Mars2 | alternative polyA | XM_003750699.5 | 0.14 | 1 | 0.15 | 5.1e-14 | 6.48 | 9.46e-11 | 0.74 | FALSE |
| Brain | Mars2 | alternative polyA | XM_039084841.1 | 0.04 | 1423 | 0.03 | 4.2e-04 | 6.29 | 3.16e-10 | 0.58 | FALSE |
| Brain | Sf3b1 | alternative polyA | NM_053426.1 | 0.35 | 1 | 0.27 | 6.1e-25 | -5.5 | 3.72e-08 | 0.03 | FALSE |
| Brain | Sf3b1 | alternative polyA | XM_017596654.2 | 0.35 | 1 | 0.27 | 3.8e-25 | 5.5 | 3.72e-08 | 0.03 | FALSE |
| Brain | Coq10b | gene expression | Coq10b | 0.14 | 187 | 0.15 | 2.1e-13 | 6.69 | 2.28e-11 | 0.83 | FALSE |
| Brain | LOC686030 | gene expression | LOC686030 | 0.07 | 1 | 0.05 | 3.8e-05 | -6 | 1.98e-09 | 0.03 | FALSE |
| Brain | Mob4 | gene expression | Mob4 | 0.04 | 1 | 0.03 | 3.8e-04 | 5.88 | 4.22e-09 | 0.03 | FALSE |
| Brain | Pgap1 | gene expression | Pgap1 | 0.23 | 23 | 0.22 | 1.6e-20 | -6.05 | 1.43e-09 | 0.02 | FALSE |
| Brain | Sf3b1 | gene expression | Sf3b1 | 0.03 | 16 | 0.02 | 2.9e-03 | 5.95 | 2.63e-09 | 0.33 | FALSE |
| Brain | Slc39a10 | gene expression | Slc39a10 | 0.04 | 1 | 0.02 | 8.6e-03 | 5.58 | 2.45e-08 | 0.03 | FALSE |
| Brain | Mars2 | isoform ratio | XM_003750699.5 | 0.16 | 1 | 0.18 | 4.4e-16 | 6.42 | 1.39e-10 | 0.66 | FALSE |
| Brain | Mars2 | isoform ratio | XM_039084841.1 | 0.05 | 1 | 0.05 | 3.0e-05 | -6.48 | 9.46e-11 | 0.33 | FALSE |
| Brain | Sf3b1 | isoform ratio | XM_017596654.2 | 0.06 | 1 | 0.05 | 1.8e-05 | 5.57 | 2.53e-08 | 0.03 | FALSE |
| Brain | Mars2 | mRNA stability | Mars2 | 0.04 | 1423 | 0.02 | 8.6e-03 | -6.23 | 4.54e-10 | 0.57 | FALSE |
| Brain | Pgap1 | mRNA stability | Pgap1 | 0.07 | 1852 | 0.04 | 6.2e-05 | -6 | 2.01e-09 | 0.46 | FALSE |
| IL | Mars2 | alternative polyA | XM_003750699.5 | 0.17 | 998 | 0.06 | 1.3e-02 | -6.04 | 1.50e-09 | 0.31 | FALSE |
| IL | Mars2 | isoform ratio | XM_003750699.5 | 0.21 | 26 | 0.14 | 3.6e-04 | -5.6 | 2.14e-08 | 0.45 | FALSE |
| IL | LOC120094685 | intron excision ratio | chr9_54843555_54875975 | 0.23 | 1 | 0.08 | 6.6e-03 | -5.81 | 6.26e-09 | 0.05 | FALSE |
| LHb | Mars2 | alternative polyA | XM_003750699.5 | 0.31 | 998 | 0.13 | 6.8e-04 | -6.07 | 1.29e-09 | 0.53 | FALSE |
| LHb | Sf3b1 | alternative polyA | NM_053426.1 | 0.31 | 11 | 0.15 | 1.8e-04 | 6.31 | 2.83e-10 | 0.56 | FALSE |
| LHb | Sf3b1 | alternative polyA | XM_017596654.2 | 0.29 | 18 | 0.15 | 2.6e-04 | -6.31 | 2.83e-10 | 0.54 | FALSE |
| LHb | Coq10b | gene expression | Coq10b | 0.79 | 1 | 0.1 | 2.6e-03 | 6.48 | 8.89e-11 | 0.27 | FALSE |
| LHb | Mars2 | isoform ratio | XM_003750699.5 | 0.33 | 998 | 0.16 | 1.5e-04 | -5.87 | 4.32e-09 | 0.48 | FALSE |
| Liver | Mars2 | alternative polyA | XM_003750699.5 | 0.28 | 457 | 0.29 | 3.2e-32 | 5.38 | 7.40e-08 | 0.01 | FALSE |
| Liver | Mars2 | alternative polyA | XM_039084841.1 | 0.11 | 28 | 0.13 | 4.8e-14 | 5.48 | 4.23e-08 | 0.01 | FALSE |
| Liver | Dnah7 | alternative TSS | XM_039084571.1 | 0.03 | 1 | 0.01 | 3.9e-02 | 6.33 | 2.39e-10 | 0.03 | FALSE |
| Liver | Dnah7 | alternative TSS | XM_039084571.1 | 0.03 | 1 | 0.01 | 2.6e-02 | 6.13 | 8.61e-10 | 0.03 | FALSE |
| Liver | Ankrd44 | gene expression | Ankrd44 | 0.04 | 1 | 0.04 | 2.0e-05 | -5.45 | 5.08e-08 | 0.03 | FALSE |
| Liver | Mars2 | gene expression | Mars2 | 0.14 | 21 | 0.16 | 2.5e-17 | 5.5 | 3.81e-08 | 0.01 | FALSE |
| Liver | Mars2 | isoform ratio | XM_003750699.5 | 0.24 | 415 | 0.29 | 1.8e-32 | 5.36 | 8.11e-08 | 0.01 | FALSE |
| Liver | Mars2 | isoform ratio | XM_039084841.1 | 0.12 | 26 | 0.14 | 1.9e-15 | 5.47 | 4.41e-08 | 0.01 | FALSE |
| Liver | Hspd1 | mRNA stability | Hspd1 | 0.21 | 1 | 0.18 | 4.3e-20 | 6.4 | 1.58e-10 | 0.82 | FALSE |
| Liver | Pgap1 | mRNA stability | Pgap1 | 0.04 | 2 | 0.01 | 7.6e-03 | -6.6 | 4.07e-11 | 0.63 | FALSE |
| NAcc | Mars2 | alternative polyA | XM_003750699.5 | 0.14 | 1 | 0.15 | 6.2e-17 | 5.77 | 8.05e-09 | 0.04 | FALSE |
| NAcc | Sf3b1 | alternative polyA | NM_053426.1 | 0.16 | 1 | 0.13 | 5.1e-15 | -5.49 | 4.03e-08 | 0.02 | FALSE |
| NAcc | Sf3b1 | alternative polyA | XM_017596654.2 | 0.16 | 1 | 0.13 | 2.4e-14 | 5.49 | 4.03e-08 | 0.02 | FALSE |
| NAcc | Hecw2 | alternative TSS | XM_039083601.1 | 0.02 | 90 | 0.02 | 2.1e-03 | -5.79 | 6.89e-09 | 0.68 | FALSE |
| NAcc | Ankrd44 | gene expression | Ankrd44 | 0.05 | 1 | 0.04 | 4.7e-05 | 5.53 | 3.29e-08 | 0.03 | FALSE |
| NAcc | Coq10b | gene expression | Coq10b | 0.03 | 1 | 0.01 | 1.6e-02 | 6.35 | 2.21e-10 | 0.08 | FALSE |
| NAcc | Hecw2 | gene expression | Hecw2 | 0.07 | 12 | 0.06 | 1.4e-07 | -5.39 | 7.05e-08 | 0.05 | FALSE |
| NAcc | LOC686030 | gene expression | LOC686030 | 0.09 | 2027 | 0.08 | 6.6e-10 | 5.74 | 9.53e-09 | 0.1 | FALSE |
| NAcc | Mob4 | gene expression | Mob4 | 0.05 | 1399 | 0.03 | 9.5e-05 | -6.22 | 4.91e-10 | 0.56 | FALSE |
| NAcc | Mars2 | isoform ratio | XM_003750699.5 | 0.14 | 1 | 0.15 | 3.8e-17 | 5.77 | 8.05e-09 | 0.04 | FALSE |
| NAcc | Mars2 | isoform ratio | XM_039084841.1 | 0.03 | 141 | 0.02 | 1.7e-03 | -6.14 | 8.43e-10 | 0.43 | FALSE |
| NAcc | Coq10b | mRNA stability | Coq10b | 0.04 | 1 | 0.02 | 1.9e-03 | 5.34 | 9.09e-08 | 0.03 | FALSE |
| OFC | Sf3b1 | alternative polyA | NM_053426.1 | 0.35 | 953 | 0.1 | 2.1e-03 | 5.85 | 4.97e-09 | 0.44 | FALSE |
| OFC | Sf3b1 | alternative polyA | XM_017596654.2 | 0.33 | 953 | 0.1 | 2.8e-03 | -5.86 | 4.52e-09 | 0.42 | FALSE |
| OFC | Mars2 | isoform ratio | XM_003750699.5 | 0.15 | 998 | 0.04 | 4.0e-02 | -6.04 | 1.52e-09 | 0.26 | FALSE |
| PL | Mars2 | alternative polyA | XM_003750699.5 | 0.12 | 1423 | 0.12 | 7.2e-13 | -5.9 | 3.73e-09 | 0.25 | FALSE |
| PL | Mars2 | alternative polyA | XM_039084841.1 | 0.04 | 1 | 0.03 | 3.9e-04 | -6.67 | 2.60e-11 | 0.17 | FALSE |
| PL | Sf3b1 | alternative polyA | NM_053426.1 | 0.33 | 48 | 0.21 | 3.0e-23 | 5.86 | 4.57e-09 | 0.03 | FALSE |
| PL | Sf3b1 | alternative polyA | XM_017596654.2 | 0.31 | 30 | 0.21 | 2.1e-22 | -5.85 | 4.88e-09 | 0.03 | FALSE |
| PL | Slc39a10 | alternative TSS | XM_039083852.1 | 0.07 | 1 | 0.04 | 9.7e-06 | -5.92 | 3.21e-09 | 0.23 | FALSE |
| PL | Coq10b | gene expression | Coq10b | 0.06 | 1 | 0.05 | 2.9e-06 | 6.31 | 2.84e-10 | 0.65 | FALSE |
| PL | LOC120094685 | gene expression | LOC120094685 | 0.05 | 1 | 0.04 | 2.3e-05 | -6.03 | 1.67e-09 | 0.22 | FALSE |
| PL | Pgap1 | gene expression | Pgap1 | 0.05 | 1852 | 0.03 | 3.3e-04 | -6.42 | 1.38e-10 | 0.56 | FALSE |
| PL | Plcl1 | gene expression | Plcl1 | 0.03 | 1655 | 0 | 1.7e-01 | 5.91 | 3.52e-09 | 0.52 | FALSE |
| PL | Hecw2 | isoform ratio | XM_039083600.1 | 0.02 | 1950 | 0.01 | 6.7e-02 | 6.16 | 7.12e-10 | 0.4 | FALSE |
| PL | Mars2 | isoform ratio | XM_003750699.5 | 0.11 | 1423 | 0.12 | 5.8e-13 | -5.87 | 4.43e-09 | 0.25 | FALSE |
| PL | Mars2 | isoform ratio | XM_039084841.1 | 0.03 | 8 | 0.02 | 1.8e-03 | 6.57 | 5.11e-11 | 0.6 | FALSE |
| PL | Rftn2 | isoform ratio | XM_039084840.1 | 0.02 | 1 | 0.02 | 5.0e-03 | -5.53 | 3.29e-08 | 0.03 | FALSE |
| PL | Rftn2 | isoform ratio | XM_343571.9 | 0.02 | 1 | 0.01 | 8.1e-03 | 5.53 | 3.29e-08 | 0.03 | FALSE |
| PL | Sf3b1 | isoform ratio | NM_053426.1 | 0.04 | 1 | 0.02 | 9.5e-04 | -5.45 | 5.08e-08 | 0.03 | FALSE |
| PL | Slc39a10 | isoform ratio | XM_006244936.4 | 0.05 | 1 | 0.03 | 1.5e-04 | -6.34 | 2.31e-10 | 0.5 | FALSE |
| PL | Slc39a10 | intron excision ratio | chr9_54876271_54928715 | 0.02 | 1977 | 0.01 | 1.1e-02 | 5.34 | 9.20e-08 | 0.3 | FALSE |
| PL | Slc39a10 | mRNA stability | Slc39a10 | 0.13 | 25 | 0.08 | 4.2e-09 | 5.72 | 1.09e-08 | 0.15 | FALSE |
| pVTA | Mars2 | alternative polyA | XM_003750699.5 | 0.12 | 1 | 0.11 | 1.2e-05 | 5.76 | 8.25e-09 | 0.04 | FALSE |
| pVTA | Sf3b1 | alternative polyA | NM_053426.1 | 0.21 | 1 | 0.14 | 1.9e-06 | -5.53 | 3.16e-08 | 0.04 | FALSE |
| pVTA | Sf3b1 | alternative polyA | XM_017596654.2 | 0.21 | 1 | 0.13 | 2.8e-06 | 5.53 | 3.16e-08 | 0.04 | FALSE |
| pVTA | Coq10b | gene expression | Coq10b | 0.14 | 1 | 0.1 | 3.6e-05 | 6.46 | 1.03e-10 | 0.29 | FALSE |
| pVTA | LOC686030 | gene expression | LOC686030 | 0.09 | 2027 | 0.05 | 3.9e-03 | 6.2 | 5.79e-10 | 0.38 | FALSE |
| pVTA | Mars2 | isoform ratio | XM_003750699.5 | 0.21 | 1 | 0.2 | 3.4e-09 | 5.81 | 6.33e-09 | 0.04 | FALSE |
| pVTA | Mars2 | isoform ratio | XM_039084841.1 | 0.06 | 10 | 0.05 | 3.8e-03 | -5.89 | 3.80e-09 | 0.44 | FALSE |
| pVTA | Hspd1 | mRNA stability | Hspd1 | 0.08 | 1 | 0.08 | 2.0e-04 | 6.48 | 8.89e-11 | 0.12 | FALSE |
| RMTg | Sf3b1 | alternative polyA | NM_053426.1 | 0.18 | 1 | 0.05 | 1.7e-02 | -5.45 | 5.08e-08 | 0.05 | FALSE |
| RMTg | Sf3b1 | alternative polyA | XM_017596654.2 | 0.18 | 1 | 0.06 | 1.3e-02 | 5.45 | 5.08e-08 | 0.05 | FALSE |
| RMTg | LOC686030 | intron excision ratio | chr9_55947068_55947205 | 0.13 | 1 | 0.12 | 5.0e-04 | 5.54 | 2.95e-08 | 0.05 | FALSE |