Best TWAS P=5.207991e-08 · Best GWAS P=4.133388e-06 conditioned to 0.3265657
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Mysm1 | intron excision ratio | chr5:109814620:109816121 | 0.07 | 0.00 | blup | 2170 | 0.00 | 0.09600 | 3.6 | -5.2 | 2.6e-07 | -0.79 | 0.27 | 0.34 | FALSE |
| 2 | NAcc | NA | isoform ratio | ENSRNOT00000116893 | 0.23 | 0.00 | lasso | 2 | 0.03 | 0.08700 | 4.6 | 5.4 | 5.2e-08 | 0.92 | 0.32 | 0.21 | TRUE |
| 3 | PL2 | Jun | gene expression | ENSRNOG00000026293 | 0.17 | 0.05 | enet | 23 | 0.07 | 0.00019 | 4.5 | 5.4 | 7.2e-08 | 0.75 | 0.42 | 0.55 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.