Best TWAS P=1.39549e-08 · Best GWAS P=2.551561e-09 conditioned to 0.05348188
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Axin2 | gene expression | ENSRNOG00000055010 | 0.31 | 0.25 | enet | 55 | 0.29 | 2.8e-27 | 5.7 | -5.7 | 1.4e-08 | -0.91 | 0.07 | 0.93 | TRUE |
| 2 | PL | Axin2 | gene expression | ENSRNOG00000055010 | 0.15 | 0.11 | lasso | 6 | 0.13 | 2.1e-10 | -3.8 | -5.3 | 9.1e-08 | -0.94 | 0.56 | 0.44 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.