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chr3:126,323,673-128,206,530

Best TWAS P=6.417146e-08 · Best GWAS P=5.675965e-08 conditioned to 0.1015113

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.12	0.07	top1	1	0.07	5.6e-08	-5.4	5.4	8.8e-08	-0.88	0.13	0.87	FALSE
2	BLA	Esf1	gene expression	ENSRNOG00000004777	0.66	0.36	lasso	33	0.37	6.9e-21	-5.4	-5.4	8.4e-08	1.00	0.16	0.84	FALSE
3	BLA	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.80	0.43	enet	162	0.44	6.0e-26	-5.3	5.2	1.6e-07	-0.89	0.17	0.83	FALSE
4	BLA	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.79	0.43	enet	169	0.44	7.1e-26	-5.3	-5.2	1.7e-07	0.90	0.17	0.83	FALSE
5	BLA	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.60	0.20	lasso	17	0.22	8.0e-12	-5.3	5.3	1.4e-07	-0.99	0.17	0.83	FALSE
6	Brain	Esf1	gene expression	ENSRNOG00000004777	0.69	0.52	enet	101	0.53	7.6e-58	-5.1	-5.1	3.0e-07	0.99	0.18	0.82	FALSE
7	Brain	Esf1	intron excision ratio	chr3:127505805:127507637	0.10	0.06	top1	1	0.06	2.9e-06	-5.3	-5.3	1.3e-07	0.81	0.18	0.78	FALSE
8	Brain	Esf1	intron excision ratio	chr3:127505805:127507789	0.17	0.09	top1	1	0.09	6.1e-09	-5.3	5.3	1.3e-07	-0.91	0.18	0.81	FALSE
9	Brain	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.71	0.49	lasso	28	0.49	3.6e-51	-5.3	5.3	1.1e-07	-1.00	0.17	0.83	FALSE
10	Brain	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.71	0.48	lasso	45	0.49	8.0e-51	-5.3	-5.3	1.1e-07	1.00	0.17	0.83	FALSE
11	Brain	Ndufaf5	intron excision ratio	chr3:127526933:127536740	0.07	0.03	top1	1	0.03	1.2e-03	-5.3	5.3	1.3e-07	-0.82	0.07	0.16	FALSE
12	Brain	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.09	0.04	top1	1	0.04	5.0e-05	-5.3	5.3	1.3e-07	-0.78	0.15	0.67	FALSE
13	IL	Tasp1	intron excision ratio	chr3:127355890:127385049	0.25	0.01	enet	9	0.06	1.6e-02	-5.3	-5.1	2.7e-07	0.97	0.20	0.56	FALSE
14	IL	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.41	0.06	enet	4	0.09	3.4e-03	-5.3	5.2	2.0e-07	-0.84	0.18	0.69	FALSE
15	IL	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.42	0.15	top1	1	0.15	2.2e-04	-5.3	-5.3	1.1e-07	0.95	0.09	0.11	FALSE
16	LHb	Esf1	gene expression	ENSRNOG00000004777	0.70	0.50	top1	1	0.50	9.3e-14	-5.3	-5.3	1.3e-07	0.91	0.18	0.82	FALSE
17	LHb	Ism1	gene expression	ENSRNOG00000063262	0.48	0.45	lasso	23	0.47	9.7e-13	-4.9	-5.3	1.2e-07	0.97	0.33	0.67	FALSE
18	LHb	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.43	0.18	enet	14	0.24	1.9e-06	-5.3	5.2	2.2e-07	-0.94	0.19	0.76	FALSE
19	LHb	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.42	0.22	lasso	4	0.24	2.5e-06	-5.3	-5.2	1.7e-07	0.98	0.19	0.77	FALSE
20	Liver	Esf1	gene expression	ENSRNOG00000004777	0.09	0.04	lasso	16	0.04	1.2e-05	-5.3	5.3	1.1e-07	-0.99	0.17	0.83	FALSE
21	Liver	Ndufaf5	gene expression	ENSRNOG00000004784	0.17	0.09	lasso	21	0.10	1.1e-10	-5.3	5.3	1.3e-07	-1.00	0.18	0.81	FALSE
22	NAcc	Esf1	gene expression	ENSRNOG00000004777	0.48	0.24	lasso	4	0.24	3.7e-06	-5.3	-5.3	1.3e-07	1.00	0.19	0.80	FALSE
23	NAcc	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.63	0.21	top1	1	0.21	1.9e-05	-5.3	5.3	1.1e-07	-0.93	0.10	0.17	FALSE
24	NAcc	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.61	0.21	top1	1	0.21	1.5e-05	-5.3	-5.3	1.1e-07	0.93	0.10	0.17	FALSE
25	NAcc2	Esf1	gene expression	ENSRNOG00000004777	0.47	0.25	top1	1	0.25	6.0e-14	-5.3	-5.3	1.3e-07	0.87	0.19	0.81	FALSE
26	NAcc2	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.60	0.40	blup	1671	0.41	7.2e-24	-5.3	5.2	2.0e-07	-0.99	0.16	0.84	FALSE
27	NAcc2	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.60	0.39	blup	1671	0.41	2.0e-23	-5.3	-5.2	1.9e-07	0.99	0.16	0.84	FALSE
28	OFC	Esf1	gene expression	ENSRNOG00000004777	0.65	0.39	top1	1	0.39	3.8e-10	-5.2	-5.2	1.7e-07	0.90	0.21	0.73	FALSE
29	OFC	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.58	0.21	blup	1669	0.23	4.6e-06	-5.3	5.3	1.4e-07	-0.98	0.19	0.81	FALSE
30	OFC	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.61	0.21	blup	1669	0.24	1.6e-06	-5.3	-5.3	1.3e-07	0.98	0.19	0.81	FALSE
31	PL	Esf1	gene expression	ENSRNOG00000004777	0.60	0.25	top1	1	0.25	1.2e-06	-5.3	-5.3	1.1e-07	0.95	0.12	0.38	FALSE
32	PL	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.70	0.26	top1	1	0.26	7.9e-07	-5.3	5.3	1.1e-07	-0.93	0.13	0.53	FALSE
33	PL	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.70	0.26	top1	1	0.26	7.0e-07	-5.3	-5.3	1.1e-07	0.93	0.14	0.57	FALSE
34	PL2	Esf1	gene expression	ENSRNOG00000004777	0.50	0.29	top1	1	0.29	5.2e-16	-5.4	-5.4	6.4e-08	0.84	0.10	0.90	TRUE
35	PL2	Esf1	intron excision ratio	chr3:127505805:127507637	0.08	0.02	top1	1	0.02	1.9e-02	-5.3	-5.3	1.2e-07	0.82	0.07	0.06	FALSE
36	PL2	Esf1	intron excision ratio	chr3:127505805:127507789	0.11	0.05	top1	1	0.05	9.3e-04	-5.3	5.3	1.2e-07	-0.84	0.09	0.22	FALSE
37	PL2	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.79	0.42	enet	188	0.43	3.2e-25	-5.4	5.2	1.6e-07	-0.99	0.16	0.84	FALSE
38	PL2	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.84	0.42	enet	188	0.42	1.0e-24	-5.4	-5.2	1.7e-07	0.99	0.16	0.84	FALSE
39	PL2	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.16	0.08	top1	1	0.08	3.8e-05	-5.4	5.4	6.4e-08	-0.77	0.09	0.66	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.