Best TWAS P=1.674605e-07 · Best GWAS P=5.588984e-06 conditioned to 0.7722886
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver | Map3k3 | gene expression | ENSRNOG00000061424 | 0.03 | 0.00 | blup | 1859 | 0.01 | 0.0110 | -3.5 | -5.2 | 1.7e-07 | 0.84 | 0.33 | 0.55 | TRUE |
| 2 | Liver | Ddx42 | mRNA stability | ENSRNOG00000009474 | 0.04 | 0.01 | blup | 2012 | 0.01 | 0.0095 | -3.1 | -5.1 | 3.2e-07 | 0.76 | 0.43 | 0.31 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.