Hub : Traits : tb_th_sd : ←

chr2:150,527,756-154,576,513

Best TWAS P=9.713924e-09 · Best GWAS P=2.815998e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Mfsd1	gene expression	ENSRNOG00000013790	0.18	0.08	blup	2549	0.10	1.1e-11	3.8	5.4	8.0e-08	0.82	0.53	0.47	TRUE
2	Adipose	Gfm1	mRNA stability	ENSRNOG00000012873	0.23	0.10	blup	2403	0.12	1.4e-13	5.2	-5.7	1.4e-08	-0.84	0.80	0.19	FALSE
3	BLA	Mlf1	gene expression	ENSRNOG00000012827	0.09	0.04	blup	2529	0.05	1.6e-03	5.2	-5.5	3.7e-08	-0.80	0.59	0.30	TRUE
4	Brain	AABR07011672.1	gene expression	ENSRNOG00000028561	0.03	0.01	enet	7	0.01	1.6e-02	4.5	5.1	2.7e-07	0.72	0.42	0.34	FALSE
5	Brain	Shox2	mRNA stability	ENSRNOG00000012478	0.04	0.02	top1	1	0.02	7.3e-03	5.4	5.4	5.9e-08	0.90	0.06	0.04	FALSE
6	IL	Mlf1	gene expression	ENSRNOG00000012827	0.38	0.11	blup	2527	0.13	4.8e-04	5.7	-5.7	9.7e-09	-0.92	0.40	0.56	TRUE
7	LHb	Schip1	alternative TSS	ENSRNOT00000110983	0.21	0.02	blup	2507	0.04	4.1e-02	5.5	5.4	6.3e-08	0.92	0.39	0.30	FALSE
8	LHb	Schip1	alternative TSS	ENSRNOT00000096555	0.20	0.06	top1	1	0.06	1.7e-02	5.5	-5.5	5.0e-08	-0.96	0.12	0.05	FALSE
9	LHb	Schip1	alternative TSS	ENSRNOT00000110983	0.27	0.10	top1	1	0.10	2.6e-03	5.5	5.5	5.0e-08	0.97	0.13	0.05	FALSE
10	LHb	Mfsd1	mRNA stability	ENSRNOG00000013790	0.19	0.03	blup	2543	0.06	1.2e-02	5.9	-5.2	1.8e-07	-0.92	0.32	0.39	FALSE
11	Liver	Ift80	alternative TSS	ENSRNOT00000013216	0.03	0.01	blup	2069	0.02	5.4e-03	5.0	5.2	2.0e-07	0.82	0.43	0.39	FALSE
12	Liver	Ift80	alternative TSS	ENSRNOT00000116655	0.03	0.00	blup	2069	0.01	3.7e-02	5.1	-5.2	2.2e-07	-0.82	0.42	0.44	FALSE
13	NAcc2	Mfsd1	gene expression	ENSRNOG00000013790	0.13	0.08	enet	235	0.10	4.2e-06	5.6	-5.6	2.8e-08	-0.94	0.46	0.54	FALSE
14	OFC	Rsrc1	alternative TSS	ENSRNOT00000101324	0.24	0.01	top1	1	0.01	2.2e-01	5.3	-5.3	1.5e-07	-0.83	0.10	0.05	FALSE
15	OFC	Rsrc1	alternative TSS	ENSRNOT00000112233	0.28	0.01	top1	1	0.01	2.2e-01	5.2	5.2	2.0e-07	0.84	0.10	0.05	FALSE
16	OFC	Schip1	isoform ratio	ENSRNOT00000057473	0.30	0.12	top1	1	0.12	9.7e-04	5.6	5.6	1.6e-08	0.93	0.14	0.07	FALSE
17	OFC	Schip1	isoform ratio	ENSRNOT00000115543	0.33	0.00	blup	2512	0.03	7.3e-02	4.0	-5.6	2.4e-08	-0.83	0.38	0.19	FALSE
18	PL2	B3galnt1	gene expression	ENSRNOG00000012019	0.16	0.18	top1	1	0.18	7.8e-10	5.1	5.1	3.2e-07	0.74	0.25	0.75	FALSE
19	PL2	Mlf1	gene expression	ENSRNOG00000012827	0.14	0.06	enet	19	0.07	1.4e-04	5.2	-5.6	2.1e-08	0.02	0.43	0.56	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.