Best TWAS P=6.411419e-08 · Best GWAS P=2.034285e-08 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pgap1 | gene expression | ENSRNOG00000013388 | 0.06 | 0.04 | top1 | 1 | 0.04 | 1.6e-05 | 5.3 | 5.3 | 1.1e-07 | 0.90 | 0.16 | 0.72 | FALSE |
| 2 | Adipose | NA | gene expression | ENSRNOG00000064815 | 0.06 | 0.05 | top1 | 1 | 0.05 | 7.2e-06 | 5.3 | 5.3 | 9.1e-08 | 0.87 | 0.15 | 0.63 | FALSE |
| 3 | Adipose | Slc39a10 | isoform ratio | ENSRNOT00000016262 | 0.02 | 0.02 | top1 | 1 | 0.01 | 7.3e-03 | 5.4 | -5.4 | 7.5e-08 | -0.66 | 0.06 | 0.06 | FALSE |
| 4 | BLA | Coq10b | gene expression | ENSRNOG00000014456 | 0.05 | 0.03 | top1 | 1 | 0.03 | 6.9e-03 | 5.4 | 5.4 | 6.4e-08 | 0.98 | 0.06 | 0.07 | TRUE |
| 5 | BLA | NA | gene expression | ENSRNOG00000065339 | 0.05 | 0.04 | enet | 17 | 0.04 | 2.8e-03 | 5.6 | 5.2 | 1.8e-07 | 0.99 | 0.36 | 0.45 | FALSE |
| 6 | Brain | Coq10b | gene expression | ENSRNOG00000014456 | 0.14 | 0.17 | enet | 254 | 0.18 | 4.3e-16 | 5.4 | 5.3 | 1.0e-07 | 0.97 | 0.18 | 0.82 | FALSE |
| 7 | LHb | Coq10b | gene expression | ENSRNOG00000014456 | 0.60 | 0.06 | top1 | 1 | 0.06 | 1.6e-02 | 5.3 | 5.3 | 9.3e-08 | 0.94 | 0.05 | 0.09 | FALSE |
| 8 | Liver | Hspd1 | mRNA stability | ENSRNOG00000014525 | 0.22 | 0.19 | top1 | 1 | 0.19 | 2.6e-20 | 5.4 | 5.4 | 7.2e-08 | 0.98 | 0.13 | 0.87 | FALSE |
| 9 | NAcc2 | Coq10b | gene expression | ENSRNOG00000014456 | 0.14 | 0.09 | top1 | 1 | 0.09 | 1.3e-05 | 5.4 | 5.4 | 8.1e-08 | 0.98 | 0.09 | 0.36 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.