Best TWAS P=2.85e-08 · Best GWAS P=1.39e-08 conditioned to 1e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Arhgap32 | alternative TSS | XM_006242778.4 | 0.09 | 3 | 0.09 | 1.5e-10 | 5.25 | 1.55e-07 | 0.44 | FALSE |
| Adipose | Arhgap32 | gene expression | Arhgap32 | 0.06 | 1631 | 0.05 | 4.3e-06 | -5.22 | 1.76e-07 | 0.58 | FALSE |
| BLA | Barx2 | gene expression | Barx2 | 0.21 | 76 | 0.16 | 5.1e-09 | -5.28 | 1.27e-07 | 0.39 | FALSE |
| BLA | Kcnj1 | gene expression | Kcnj1 | 0.05 | 1 | 0.01 | 5.0e-02 | 5.22 | 1.82e-07 | 0.04 | FALSE |
| Brain | Arhgap32 | alternative TSS | XM_006242778.4 | 0.06 | 1 | 0.05 | 4.2e-05 | 5.2 | 2.04e-07 | 0.08 | FALSE |
| Brain | Arhgap32 | gene expression | Arhgap32 | 0.28 | 28 | 0.3 | 1.1e-28 | 5.35 | 8.67e-08 | 0.41 | FALSE |
| Brain | Kcnj5 | gene expression | Kcnj5 | 0.04 | 1 | 0.04 | 1.2e-04 | 5.47 | 4.49e-08 | 0.15 | FALSE |
| Brain | Arhgap32 | isoform ratio | XM_008766070.3 | 0.05 | 1 | 0.03 | 4.9e-04 | -5.21 | 1.87e-07 | 0.06 | FALSE |
| Brain | Kcnj5 | isoform ratio | NM_017297.2 | 0.19 | 27 | 0.22 | 3.1e-20 | -5.42 | 5.89e-08 | 0.72 | FALSE |
| Brain | Kcnj5 | isoform ratio | XR_005487750.1 | 0.17 | 1 | 0.21 | 6.9e-19 | -5.38 | 7.53e-08 | 0.57 | FALSE |
| Brain | Arhgap32 | intron excision ratio | chr8_30624734_30658098 | 0.05 | 1650 | 0.03 | 7.0e-04 | -5.19 | 2.08e-07 | 0.44 | FALSE |
| Brain | Arhgap32 | mRNA stability | Arhgap32 | 0.03 | 1 | 0.01 | 3.7e-02 | 5.19 | 2.09e-07 | 0.03 | FALSE |
| IL | Arhgap32 | gene expression | Arhgap32 | 0.16 | 1 | 0.03 | 6.0e-02 | -5.3 | 1.15e-07 | 0.05 | FALSE |
| LHb | Barx2 | gene expression | Barx2 | 0.11 | 2 | 0.11 | 1.7e-03 | 5.18 | 2.24e-07 | 0.36 | FALSE |
| LHb | Kcnj5 | isoform ratio | NM_017297.2 | 0.39 | 1 | 0.45 | 6.0e-12 | 5.38 | 7.53e-08 | 0.55 | FALSE |
| LHb | Kcnj5 | isoform ratio | XR_005487750.1 | 0.35 | 274 | 0.38 | 4.4e-10 | -5.3 | 1.18e-07 | 0.59 | FALSE |
| Liver | Arhgap32 | alternative TSS | XM_006242777.4 | 0.02 | 1 | 0.01 | 3.1e-02 | -5.38 | 7.53e-08 | 0.03 | FALSE |
| Liver | Fli1 | gene expression | Fli1 | 0.03 | 1 | 0.02 | 1.2e-03 | -5.2 | 2.04e-07 | 0.04 | FALSE |
| NAcc | Arhgap32 | alternative TSS | XM_006242778.4 | 0.04 | 1 | 0.04 | 2.1e-05 | 5.2 | 2.04e-07 | 0.23 | FALSE |
| NAcc | Arhgap32 | gene expression | Arhgap32 | 0.03 | 4 | 0.04 | 5.9e-06 | 5.27 | 1.36e-07 | 0.46 | FALSE |
| NAcc | Kcnj1 | gene expression | Kcnj1 | 0.03 | 1 | 0.04 | 6.1e-06 | 5.47 | 4.49e-08 | 0.45 | FALSE |
| NAcc | Arhgap32 | isoform ratio | XM_008766070.3 | 0.02 | 1 | 0.02 | 7.8e-04 | -5.21 | 1.87e-07 | 0.04 | FALSE |
| NAcc | Kcnj5 | isoform ratio | NM_017297.2 | 0.17 | 31 | 0.28 | 4.9e-32 | -5.22 | 1.75e-07 | 0.44 | FALSE |
| NAcc | Kcnj5 | isoform ratio | XR_005487750.1 | 0.14 | 14 | 0.18 | 7.6e-21 | 5.26 | 1.41e-07 | 0.47 | FALSE |
| NAcc | Arhgap32 | intron excision ratio | chr8_30674889_30676047 | 0.04 | 19 | 0.05 | 1.7e-06 | -5.55 | 2.85e-08 | 0.49 | TRUE |
| NAcc | Arhgap32 | intron excision ratio | chr8_30674889_30676050 | 0.04 | 1 | 0.05 | 1.8e-06 | 5.47 | 4.41e-08 | 0.59 | FALSE |
| NAcc | Kcnj5 | intron excision ratio | chr8_30732405_30752814 | 0.02 | 1 | 0.02 | 2.7e-03 | 5.2 | 2.04e-07 | 0.03 | FALSE |
| NAcc | Kcnj5 | mRNA stability | Kcnj5 | 0.03 | 1 | 0.04 | 2.4e-05 | 5.5 | 3.71e-08 | 0.57 | FALSE |
| PL | Arhgap32 | alternative TSS | XM_039082294.1 | 0.04 | 1 | 0.02 | 4.1e-03 | -5.22 | 1.83e-07 | 0.04 | FALSE |
| PL | Arhgap32 | gene expression | Arhgap32 | 0.12 | 35 | 0.13 | 4.1e-14 | 5.43 | 5.67e-08 | 0.54 | FALSE |
| PL | Barx2 | gene expression | Barx2 | 0.07 | 1 | 0.04 | 8.7e-05 | 5.21 | 1.87e-07 | 0.1 | FALSE |
| PL | Kcnj5 | isoform ratio | NM_017297.2 | 0.12 | 66 | 0.26 | 1.7e-28 | 5.41 | 6.34e-08 | 0.42 | FALSE |
| PL | Kcnj5 | isoform ratio | XR_005487750.1 | 0.18 | 22 | 0.27 | 1.4e-29 | 5.47 | 4.46e-08 | 0.46 | FALSE |
| pVTA | Barx2 | gene expression | Barx2 | 0.14 | 27 | 0.11 | 1.4e-05 | -5.45 | 5.16e-08 | 0.34 | FALSE |
| pVTA | Kcnj5 | isoform ratio | NM_017297.2 | 0.26 | 30 | 0.33 | 6.2e-15 | 5.45 | 5.14e-08 | 0.67 | FALSE |
| pVTA | Kcnj5 | isoform ratio | XR_005487750.1 | 0.25 | 1 | 0.29 | 8.1e-13 | -5.38 | 7.53e-08 | 0.57 | FALSE |
| RMTg | Kcnj5 | gene expression | Kcnj5 | 0.18 | 22 | 0.06 | 8.6e-03 | -5.4 | 6.75e-08 | 0.31 | FALSE |
| RMTg | Kcnj5 | isoform ratio | NM_017297.2 | 0.16 | 1538 | 0.08 | 3.1e-03 | -5.51 | 3.62e-08 | 0.6 | FALSE |
| RMTg | Kcnj5 | isoform ratio | XR_005487750.1 | 0.17 | 1 | 0.16 | 3.8e-05 | -5.22 | 1.83e-07 | 0.06 | FALSE |