Best TWAS P=1.142275e-07 · Best GWAS P=3.013682e-08 conditioned to 1.533028e-39
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | IL | Rps10 | gene expression | ENSRNOG00000000490 | 0.63 | 0.25 | enet | 121 | 0.35 | 2.3e-09 | 4.4 | -5.2 | 2.4e-07 | -0.83 | 0.58 | 0.42 | TRUE |
2 | Liver | Taf11 | gene expression | ENSRNOG00000024601 | 0.09 | 0.02 | enet | 58 | 0.03 | 5.0e-04 | 2.2 | 5.1 | 3.4e-07 | 0.30 | 0.78 | 0.10 | FALSE |
3 | NAcc | NA | gene expression | ENSRNOG00000058912 | 0.21 | 0.11 | top1 | 1 | 0.11 | 2.2e-08 | 5.1 | -5.1 | 3.5e-07 | -0.60 | 0.30 | 0.70 | TRUE |
4 | PL | Nudt3 | gene expression | ENSRNOG00000061176 | 0.22 | 0.10 | top1 | 1 | 0.10 | 2.6e-08 | 5.3 | 5.3 | 1.1e-07 | 0.89 | 0.12 | 0.87 | TRUE |
5 | PL | Ilrun | intron excision ratio | chr20:5812549:5825318 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.0e-02 | 2.2 | -5.3 | 1.5e-07 | -0.06 | 0.78 | 0.06 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.