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chr10:102,999,385-104,353,671

Best TWAS P=2.872901e-10 · Best GWAS P=3.768659e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Usp36	gene expression	ENSRNOG00000028255	0.09	0.04	top1	1	0.04	3.7e-05	-5.81	5.8	6.2e-09	-0.41	0.10	0.34	TRUE
2	Adipose	Cep295nl	gene expression	ENSRNOG00000033143	0.25	0.12	enet	194	0.22	6.9e-24	-0.07	-6.3	2.9e-10	0.50	0.96	0.04	TRUE
3	Adipose	Cep295nl	isoform ratio	ENSRNOT00000004290	0.08	0.03	top1	1	0.03	4.5e-04	-5.86	-5.9	4.6e-09	0.49	0.07	0.18	FALSE
4	Adipose	C1qtnf1	intron excision ratio	chr10:103675735:103678361	0.06	0.02	top1	1	0.02	9.5e-04	-5.87	-5.9	4.4e-09	0.50	0.06	0.10	FALSE
5	BLA	Cep295nl	gene expression	ENSRNOG00000033143	0.23	0.10	top1	1	0.10	5.6e-06	-5.75	5.7	8.9e-09	-0.92	0.19	0.62	FALSE
6	BLA	Cant1	mRNA stability	ENSRNOG00000003239	0.21	0.00	enet	54	0.03	1.0e-02	-5.81	-5.6	2.7e-08	0.93	0.17	0.54	TRUE
7	Brain	Cep295nl	gene expression	ENSRNOG00000033143	0.33	0.24	lasso	28	0.28	5.4e-26	-5.84	5.8	6.8e-09	-0.96	0.14	0.86	FALSE
8	Brain	Cep295nl	intron excision ratio	chr10:103543287:103543754	0.10	0.03	blup	1803	0.03	4.2e-04	-4.68	-5.9	4.2e-09	0.78	0.78	0.19	TRUE
9	Brain	Usp36	mRNA stability	ENSRNOG00000028255	0.08	0.03	top1	1	0.03	4.1e-04	-5.86	-5.9	4.6e-09	0.92	0.09	0.32	FALSE
10	IL	Cep295nl	gene expression	ENSRNOG00000033143	0.42	0.14	top1	1	0.14	3.4e-04	-5.86	5.9	4.6e-09	-0.47	0.10	0.18	FALSE
11	NAcc	Pgs1	intron excision ratio	chr10:103233322:103241803	0.39	0.13	top1	1	0.13	9.5e-04	-5.86	5.9	4.6e-09	-0.42	0.07	0.08	FALSE
12	PL2	Usp36	intron excision ratio	chr10:103526568:103528588	0.10	0.04	top1	1	0.04	3.4e-03	-5.14	-5.1	2.8e-07	0.33	0.09	0.04	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.