Best TWAS P=1.551672e-08 · Best GWAS P=8.366924e-17 conditioned to 7.571782e-12
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | Sox9 | gene expression | ENSRNOG00000002607 | 0.34 | 0.30 | enet | 46 | 0.32 | 7.3e-18 | 5.6 | -5.4 | 5.5e-08 | 0.34 | 1.00 | 0.00 | FALSE |
| 2 | Brain | Sox9 | gene expression | ENSRNOG00000002607 | 0.15 | 0.19 | top1 | 1 | 0.19 | 4.6e-17 | 5.7 | -5.7 | 1.6e-08 | 0.33 | 1.00 | 0.00 | TRUE |
| 3 | NAcc | Sox9 | gene expression | ENSRNOG00000002607 | 0.32 | 0.02 | top1 | 1 | 0.03 | 9.2e-02 | 5.2 | -5.2 | 2.4e-07 | 0.22 | 0.13 | 0.05 | FALSE |
| 4 | PL2 | Sox9 | gene expression | ENSRNOG00000002607 | 0.27 | 0.22 | blup | 2666 | 0.23 | 1.1e-12 | 5.6 | -5.3 | 1.5e-07 | 0.47 | 1.00 | 0.00 | FALSE |
| 5 | PL2 | Slc39a11 | mRNA stability | ENSRNOG00000031213 | 0.22 | 0.08 | enet | 170 | 0.12 | 6.2e-07 | 3.0 | 5.5 | 3.0e-08 | -0.31 | 0.99 | 0.00 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.