Best TWAS P=1.44e-09 · Best GWAS P=1.44e-09 conditioned to 2.20e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Aars2 | gene expression | Aars2 | 0.23 | 1 | 0.16 | 4.8e-17 | 5.8 | 6.48e-09 | 0.66 | FALSE |
| Adipose | Cdc5l | gene expression | Cdc5l | 0.07 | 2000 | 0.07 | 4.1e-08 | -5.66 | 1.51e-08 | 0.73 | FALSE |
| Adipose | Klc4 | gene expression | Klc4 | 0.05 | 1222 | 0.04 | 2.3e-05 | 5.34 | 9.10e-08 | 0.58 | FALSE |
| Adipose | Mrpl2 | gene expression | Mrpl2 | 0.05 | 1222 | 0.01 | 4.7e-02 | -5.19 | 2.16e-07 | 0.32 | FALSE |
| Adipose | Ptk7 | gene expression | Ptk7 | 0.19 | 1192 | 0.18 | 1.2e-19 | 5.39 | 7.18e-08 | 0.63 | FALSE |
| Adipose | Rrp36 | gene expression | Rrp36 | 0.44 | 1253 | 0.45 | 2.5e-55 | 5.3 | 1.16e-07 | 0.64 | FALSE |
| Adipose | Slc29a1 | gene expression | Slc29a1 | 0.18 | 17 | 0.13 | 5.4e-14 | -5.8 | 6.65e-09 | 0.72 | FALSE |
| BLA | Aars2 | alternative TSS | XM_006244515.4 | 0.11 | 1991 | 0.07 | 1.9e-04 | 5.27 | 1.34e-07 | 0.37 | FALSE |
| BLA | Mea1 | alternative TSS | XM_008766880.2 | 0.06 | 1 | 0.04 | 2.0e-03 | 5.26 | 1.42e-07 | 0.05 | FALSE |
| BLA | Klc4 | gene expression | Klc4 | 0.14 | 17 | 0.16 | 8.1e-09 | 5.26 | 1.42e-07 | 0.64 | FALSE |
| BLA | LOC681367 | gene expression | LOC681367 | 0.18 | 122 | 0.21 | 2.5e-11 | -5.43 | 5.57e-08 | 0.6 | FALSE |
| BLA | Mrps10 | gene expression | Mrps10 | 0.47 | 1746 | 0.39 | 4.3e-22 | 5.4 | 6.78e-08 | 0.65 | FALSE |
| BLA | Rrp36 | gene expression | Rrp36 | 0.42 | 105 | 0.51 | 5.6e-31 | -5.2 | 2.00e-07 | 0.62 | FALSE |
| BLA | Klc4 | isoform ratio | XM_006244516.4 | 0.06 | 1222 | 0.01 | 6.2e-02 | -5.35 | 8.85e-08 | 0.39 | FALSE |
| BLA | Trerf1 | intron excision ratio | chr9_13710850_13768409 | 0.13 | 1 | 0.11 | 1.5e-06 | -5.34 | 9.33e-08 | 0.49 | FALSE |
| BLA | Rrp36 | mRNA stability | Rrp36 | 0.12 | 18 | 0.12 | 7.3e-07 | 5.26 | 1.48e-07 | 0.56 | FALSE |
| BLA | Trerf1 | mRNA stability | Trerf1 | 0.11 | 54 | 0.1 | 3.7e-06 | -5.56 | 2.65e-08 | 0.38 | FALSE |
| Brain | Slc29a1 | alternative TSS | XM_006244561.3 | 0.04 | 1 | 0.03 | 3.4e-04 | -5.28 | 1.27e-07 | 0.03 | FALSE |
| Brain | Slc29a1 | alternative TSS | XM_006244561.3 | 0.04 | 1 | 0.04 | 2.7e-04 | -5.77 | 7.85e-09 | 0.08 | FALSE |
| Brain | C9h6orf132 | gene expression | C9h6orf132 | 0.06 | 1 | 0.05 | 2.0e-05 | -5.26 | 1.44e-07 | 0.73 | FALSE |
| Brain | Hsp90ab1 | gene expression | Hsp90ab1 | 0.11 | 10 | 0.11 | 2.8e-10 | -5.35 | 8.74e-08 | 0.57 | FALSE |
| Brain | Klc4 | gene expression | Klc4 | 0.75 | 79 | 0.67 | 9.2e-83 | -5.19 | 2.14e-07 | 0.62 | FALSE |
| Brain | Mrpl2 | gene expression | Mrpl2 | 0.05 | 1 | 0.03 | 1.5e-03 | 5.34 | 9.27e-08 | 0.07 | FALSE |
| Brain | Rrp36 | gene expression | Rrp36 | 0.6 | 56 | 0.55 | 3.0e-60 | 5.17 | 2.28e-07 | 0.61 | FALSE |
| Brain | Spats1 | gene expression | Spats1 | 0.44 | 31 | 0.34 | 1.6e-32 | 5.24 | 1.62e-07 | 0 | FALSE |
| Brain | Srf | gene expression | Srf | 0.04 | 1042 | 0.01 | 3.2e-02 | 5.27 | 1.38e-07 | 0.57 | FALSE |
| Brain | Klc4 | isoform ratio | XM_039083506.1 | 0.07 | 5 | 0.05 | 3.6e-05 | 5.51 | 3.67e-08 | 0.57 | FALSE |
| Brain | Klhdc3 | isoform ratio | XM_039083821.1 | 0.08 | 167 | 0.06 | 2.6e-06 | 5.36 | 8.55e-08 | 0.63 | FALSE |
| Brain | Klhdc3 | intron excision ratio | chr9_14302484_14303967 | 0.15 | 1 | 0.14 | 1.5e-12 | 5.34 | 9.27e-08 | 0.78 | FALSE |
| Brain | Klhdc3 | intron excision ratio | chr9_14304118_14304654 | 0.11 | 1280 | 0.11 | 9.0e-11 | -5.41 | 6.21e-08 | 0.6 | FALSE |
| Brain | Trerf1 | intron excision ratio | chr9_13768495_13856943 | 0.05 | 1 | 0.05 | 8.2e-06 | -5.23 | 1.70e-07 | 0.35 | FALSE |
| Brain | Cul7 | mRNA stability | Cul7 | 0.15 | 23 | 0.17 | 1.4e-15 | 5.38 | 7.64e-08 | 0.59 | FALSE |
| Brain | Trerf1 | mRNA stability | Trerf1 | 0.13 | 27 | 0.15 | 5.8e-14 | -5.24 | 1.59e-07 | 0.39 | FALSE |
| Eye | Zfp318 | alternative polyA | XM_039084821.1 | 0.27 | 1 | 0.14 | 4.1e-03 | -5.33 | 1.00e-07 | 0.06 | FALSE |
| IL | Trerf1 | alternative polyA | XM_039083502.1 | 0.16 | 1 | 0.07 | 1.0e-02 | -5.32 | 1.02e-07 | 0.05 | FALSE |
| IL | Nfkbie | gene expression | Nfkbie | 0.24 | 2030 | 0.09 | 3.7e-03 | -5.67 | 1.42e-08 | 0.54 | FALSE |
| IL | Klhdc3 | isoform ratio | NM_001012203.1 | 0.33 | 220 | 0.31 | 4.0e-08 | 5.9 | 3.56e-09 | 0.6 | FALSE |
| IL | Klhdc3 | intron excision ratio | chr9_14302484_14304654 | 0.29 | 46 | 0.25 | 1.0e-06 | -5.37 | 7.85e-08 | 0.59 | FALSE |
| IL | Klhdc3 | intron excision ratio | chr9_14304118_14304654 | 0.15 | 10 | 0.11 | 1.7e-03 | 5.75 | 8.95e-09 | 0.35 | FALSE |
| IL | Klhdc3 | mRNA stability | Klhdc3 | 0.14 | 1280 | 0.08 | 5.5e-03 | 5.22 | 1.84e-07 | 0.3 | FALSE |
| LHb | C9h6orf132 | gene expression | C9h6orf132 | 0.2 | 1 | 0.08 | 6.7e-03 | -5.3 | 1.19e-07 | 0.08 | FALSE |
| LHb | Klhdc3 | isoform ratio | NM_001012203.1 | 0.26 | 46 | 0.11 | 1.6e-03 | 5.27 | 1.36e-07 | 0.48 | FALSE |
| LHb | Klhdc3 | isoform ratio | XM_006244542.4 | 0.24 | 16 | 0.08 | 5.5e-03 | -5.29 | 1.26e-07 | 0.44 | FALSE |
| Liver | Capn11 | alternative polyA | XM_039084033.1 | 0.03 | 1897 | 0.01 | 1.3e-02 | 5.46 | 4.65e-08 | 0.63 | FALSE |
| Liver | Slc29a1 | alternative TSS | NM_031684.2 | 0.13 | 1 | 0.14 | 8.6e-15 | 5.98 | 2.22e-09 | 0.84 | FALSE |
| Liver | Slc29a1 | alternative TSS | XM_006244561.3 | 0.04 | 2002 | 0.02 | 3.8e-03 | 5.3 | 1.16e-07 | 0.26 | FALSE |
| Liver | Slc29a1 | alternative TSS | XM_039084162.1 | 0.08 | 1 | 0.08 | 7.5e-09 | -5.98 | 2.22e-09 | 0.84 | FALSE |
| Liver | Slc29a1 | alternative TSS | XM_006244561.3 | 0.04 | 2002 | 0.02 | 2.7e-03 | 5.29 | 1.26e-07 | 0.26 | FALSE |
| Liver | Aars2 | gene expression | Aars2 | 0.23 | 17 | 0.21 | 2.6e-23 | -5.88 | 4.04e-09 | 0.74 | FALSE |
| Liver | Capn11 | gene expression | Capn11 | 0.26 | 29 | 0.25 | 7.3e-28 | -5.93 | 2.96e-09 | 0.74 | FALSE |
| Liver | Gnmt | gene expression | Gnmt | 0.36 | 1351 | 0.32 | 1.5e-36 | 5.33 | 9.82e-08 | 0.62 | FALSE |
| Liver | Hsp90ab1 | gene expression | Hsp90ab1 | 0.03 | 2017 | 0.02 | 2.3e-03 | -5.8 | 6.58e-09 | 0.67 | FALSE |
| Liver | LOC103690501 | gene expression | LOC103690501 | 0.16 | 1697 | 0.19 | 2.8e-20 | 5.48 | 4.35e-08 | 0.73 | FALSE |
| Liver | Rrp36 | gene expression | Rrp36 | 0.42 | 1253 | 0.42 | 4.0e-50 | 5.2 | 2.00e-07 | 0.64 | FALSE |
| Liver | Slc29a1 | gene expression | Slc29a1 | 0.07 | 1 | 0.06 | 1.5e-07 | -5.49 | 3.92e-08 | 0.24 | FALSE |
| Liver | Slc35b2 | gene expression | Slc35b2 | 0.03 | 2024 | 0.02 | 2.1e-03 | -5.97 | 2.32e-09 | 0.65 | FALSE |
| Liver | Zfp318 | gene expression | Zfp318 | 0.16 | 1073 | 0.03 | 1.1e-04 | -5.31 | 1.07e-07 | 0.34 | FALSE |
| Liver | Klhdc3 | isoform ratio | NM_001012203.1 | 0.14 | 1280 | 0.17 | 1.6e-18 | -5.25 | 1.49e-07 | 0.63 | FALSE |
| Liver | Klhdc3 | isoform ratio | XM_006244542.4 | 0.14 | 1280 | 0.16 | 7.6e-18 | 5.35 | 9.03e-08 | 0.62 | FALSE |
| Liver | Slc29a1 | isoform ratio | NM_031684.2 | 0.18 | 17 | 0.18 | 2.9e-19 | -5.88 | 4.04e-09 | 0.77 | FALSE |
| Liver | Slc29a1 | isoform ratio | XM_006244560.3 | 0.04 | 15 | 0.04 | 5.7e-05 | 5.38 | 7.31e-08 | 0.68 | FALSE |
| Liver | Slc29a1 | isoform ratio | XM_039084162.1 | 0.05 | 1 | 0.04 | 2.2e-05 | -5.49 | 3.92e-08 | 0.13 | FALSE |
| Liver | Cnpy3 | intron excision ratio | chr9_14242382_14245813 | 0.03 | 1411 | 0.02 | 5.6e-03 | -5.4 | 6.79e-08 | 0.44 | FALSE |
| Liver | Slc29a1 | intron excision ratio | chr9_15399733_15405034 | 0.19 | 27 | 0.2 | 3.1e-21 | -5.85 | 4.83e-09 | 0.76 | FALSE |
| Liver | Slc29a1 | intron excision ratio | chr9_15403262_15405034 | 0.12 | 1 | 0.14 | 1.2e-15 | -5.49 | 3.92e-08 | 0.25 | FALSE |
| Liver | Pex6 | mRNA stability | Pex6 | 0.14 | 1332 | 0.11 | 4.2e-12 | -5.22 | 1.76e-07 | 0.62 | FALSE |
| NAcc | Nfkbie | gene expression | Nfkbie | 0.04 | 18 | 0.02 | 2.5e-03 | 5.33 | 9.65e-08 | 0.44 | FALSE |
| NAcc | Rrp36 | gene expression | Rrp36 | 0.34 | 43 | 0.55 | 1.5e-75 | 5.23 | 1.67e-07 | 0.64 | FALSE |
| NAcc | Trerf1 | isoform ratio | XM_006244452.4 | 0.02 | 1886 | 0.01 | 1.1e-02 | 5.26 | 1.45e-07 | 0.4 | FALSE |
| NAcc | Trerf1 | intron excision ratio | chr9_13710850_13768409 | 0.09 | 1886 | 0.08 | 2.1e-09 | 5.42 | 5.91e-08 | 0.58 | FALSE |
| NAcc | Trerf1 | intron excision ratio | chr9_13760250_13761689 | 0.06 | 1 | 0.09 | 9.6e-11 | 5.24 | 1.65e-07 | 0.63 | FALSE |
| NAcc | Trerf1 | intron excision ratio | chr9_13761791_13768409 | 0.03 | 1 | 0.02 | 2.0e-03 | 5.3 | 1.19e-07 | 0.16 | FALSE |
| NAcc | Ppp2r5d | mRNA stability | Ppp2r5d | 0.03 | 19 | 0.01 | 7.6e-03 | 5.25 | 1.56e-07 | 0.29 | FALSE |
| NAcc | Rrp36 | mRNA stability | Rrp36 | 0.03 | 1 | 0.04 | 2.1e-05 | -5.26 | 1.45e-07 | 0.44 | FALSE |
| NAcc | Trerf1 | mRNA stability | Trerf1 | 0.17 | 4 | 0.15 | 6.9e-17 | 5.21 | 1.89e-07 | 0.09 | FALSE |
| NAcc | Ubr2 | mRNA stability | Ubr2 | 0.02 | 1700 | 0.02 | 9.5e-04 | 5.19 | 2.07e-07 | 0.52 | FALSE |
| OFC | Bicral | alternative TSS | NM_001106888.1 | 0.2 | 1711 | 0.07 | 8.9e-03 | 5.19 | 2.14e-07 | 0.25 | FALSE |
| OFC | Bicral | alternative TSS | XM_006244508.4 | 0.2 | 1711 | 0.1 | 1.9e-03 | -5.21 | 1.85e-07 | 0.27 | FALSE |
| OFC | Pex6 | gene expression | Pex6 | 0.57 | 16 | 0.4 | 1.0e-10 | -5.24 | 1.60e-07 | 0.6 | FALSE |
| PL | Aars2 | alternative polyA | NM_001106891.1 | 0.04 | 1 | 0.04 | 9.6e-05 | -5.49 | 3.92e-08 | 0.08 | FALSE |
| PL | Aars2 | alternative polyA | XM_006244513.4 | 0.05 | 16 | 0.03 | 3.5e-04 | -5.69 | 1.25e-08 | 0.68 | FALSE |
| PL | Aars2 | alternative TSS | XM_006244515.4 | 0.12 | 1991 | 0.1 | 4.8e-11 | 5.18 | 2.22e-07 | 0.01 | FALSE |
| PL | Klhdc3 | alternative TSS | NM_001012203.1 | 0.03 | 1280 | 0.03 | 1.7e-04 | -5.18 | 2.27e-07 | 0.37 | FALSE |
| PL | Cul7 | gene expression | Cul7 | 0.16 | 27 | 0.18 | 4.2e-19 | 5.32 | 1.02e-07 | 0.62 | FALSE |
| PL | Hsp90ab1 | gene expression | Hsp90ab1 | 0.07 | 26 | 0.07 | 2.2e-08 | -6.03 | 1.61e-09 | 0.77 | FALSE |
| PL | Nfkbie | gene expression | Nfkbie | 0.06 | 2030 | 0.04 | 1.1e-05 | -5.73 | 1.03e-08 | 0.63 | FALSE |
| PL | Rrp36 | gene expression | Rrp36 | 0.49 | 41 | 0.61 | 3.4e-84 | 5.27 | 1.39e-07 | 0.63 | FALSE |
| PL | Slc35b2 | gene expression | Slc35b2 | 0.04 | 2025 | 0.01 | 3.8e-02 | -5.65 | 1.58e-08 | 0.57 | FALSE |
| PL | Spats1 | gene expression | Spats1 | 0.09 | 1 | 0.07 | 2.7e-08 | -5.49 | 3.92e-08 | 0.25 | FALSE |
| PL | Trerf1 | intron excision ratio | chr9_13760250_13761689 | 0.07 | 1 | 0.1 | 2.6e-11 | 5.26 | 1.43e-07 | 0.66 | FALSE |
| PL | Vegfa | intron excision ratio | chr9_14956379_14959271 | 0.03 | 1 | 0.01 | 1.6e-02 | 5.28 | 1.30e-07 | 0.03 | FALSE |
| PL | Cul7 | mRNA stability | Cul7 | 0.02 | 1229 | 0.02 | 3.9e-03 | -5.37 | 7.82e-08 | 0.57 | FALSE |
| PL | Rrp36 | mRNA stability | Rrp36 | 0.04 | 13 | 0.05 | 5.5e-06 | -5.24 | 1.60e-07 | 0.6 | FALSE |
| PL | Trerf1 | mRNA stability | Trerf1 | 0.14 | 23 | 0.17 | 1.1e-18 | 5.48 | 4.21e-08 | 0.57 | FALSE |
| pVTA | LOC681367 | gene expression | LOC681367 | 0.12 | 1517 | 0.08 | 1.8e-04 | 5.44 | 5.42e-08 | 0.57 | FALSE |
| pVTA | Nfkbie | gene expression | Nfkbie | 0.12 | 23 | 0.1 | 6.5e-05 | -5.29 | 1.20e-07 | 0.66 | FALSE |
| pVTA | Spats1 | gene expression | Spats1 | 0.12 | 2005 | 0.06 | 1.1e-03 | 5.36 | 8.20e-08 | 0.67 | FALSE |
| pVTA | Tcte1 | gene expression | Tcte1 | 0.09 | 1 | 0.06 | 2.0e-03 | -6.05 | 1.44e-09 | 0.1 | TRUE |
| pVTA | Klhdc3 | isoform ratio | NM_001012203.1 | 0.32 | 32 | 0.38 | 1.8e-17 | 5.47 | 4.40e-08 | 0.6 | FALSE |
| pVTA | Klhdc3 | isoform ratio | XM_006244542.4 | 0.39 | 1280 | 0.41 | 5.5e-19 | 5.19 | 2.08e-07 | 0.6 | FALSE |
| pVTA | Trerf1 | isoform ratio | XM_039083496.1 | 0.09 | 1886 | 0.02 | 3.2e-02 | -5.47 | 4.40e-08 | 0.32 | FALSE |
| RMTg | Cnpy3 | gene expression | Cnpy3 | 0.51 | 1 | 0.35 | 4.5e-10 | 5.19 | 2.06e-07 | 0.57 | FALSE |
| RMTg | LOC681367 | gene expression | LOC681367 | 0.14 | 1517 | 0.08 | 3.9e-03 | 5.44 | 5.42e-08 | 0.42 | FALSE |
| RMTg | Rrp36 | gene expression | Rrp36 | 0.58 | 47 | 0.18 | 1.8e-05 | 5.2 | 1.99e-07 | 0.59 | FALSE |