This is a beta version. We are working on improving and expanding this portal.
TWAS (transcriptome-wide association study) is an approach to estimate the genetic association between complex traits and transcriptomic variation. This web interface provides searchable access to TWAS results for many complex traits using GWAS and transcriptomic data from Heterogeneous Stock rats, produced by the NIDA Center of Excellence for Genetics, Genomics, and Epigenetics of Substance Use Disorders in Outbred Rats (P30DA060810). The site is based on the original TWAS hub for human data, with modifications including the addition of RNA phenotypes beyond gene expression levels using Pantry.
What can you do here? Search the full list of analyzed traits and diseases in the TRAITS tab. See all genes and loci associated with a given trait like Locomotion velocity, NPP test and browse cross-trait associations. See gene conditional analyses at individual loci like chr1:140,510,980-142,727,457 and filter all associated models. Evaluate predictive models for individual genes like Ctsc and browse all corresponding trait associations. All genes with predictive models are listed in the GENES tab. See USAGE for a more detailed guide.
For technical help with the site or data, email Daniel Munro at dmunro@health.ucsd.edu.
This site does not yet have an associated publication, and not all of the GWAS data used here have been published. To cite the Rat TWAS Hub, email Abraham Palmer and Daniel with specifics so we can decide which data can be used and which studies to cite.