Best TWAS P=1.666725e-07 · Best GWAS P=1.620274e-07 conditioned to 0.1452349
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Gad2 | gene expression | ENSRNOG00000018200 | 0.66 | 0.09 | top1 | 1 | 0.09 | 2.4e-08 | -5.2 | 5.2 | 1.7e-07 | -0.86 | 0.14 | 0.86 | TRUE |
| 2 | PL2 | NA | gene expression | ENSRNOG00000018478 | 0.20 | 0.09 | top1 | 1 | 0.09 | 1.5e-05 | -5.2 | 5.2 | 2.2e-07 | -0.84 | 0.13 | 0.43 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.