Hub : Traits : dissection: UMAP 3 of all traits : →

chr1:68,059,764-70,857,131

Best TWAS P=5.177311e-09 · Best GWAS P=7.145019e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Leng9	alternative TSS	ENSRNOT00000116488	0.02	0.01	top1	1	0.01	2.1e-02	-5.6	5.6	2.0e-08	-1.00	0.05	0.03	FALSE
2	Adipose	Rpl28	gene expression	ENSRNOG00000017127	0.09	0.00	enet	141	0.01	2.4e-02	-4.2	-5.3	1.2e-07	0.92	0.39	0.12	FALSE
3	Adipose	Lilrb4	gene expression	ENSRNOG00000027811	0.03	0.01	blup	1510	0.02	2.0e-03	-4.8	-5.2	2.1e-07	0.97	0.56	0.31	FALSE
4	Adipose	Rdh13	gene expression	ENSRNOG00000027919	0.16	0.12	lasso	20	0.12	2.2e-13	-5.3	5.3	1.0e-07	-0.99	0.38	0.62	FALSE
5	Adipose	Tmem150b	gene expression	ENSRNOG00000028273	0.03	0.01	blup	1480	0.01	2.2e-02	-5.7	-5.4	6.1e-08	0.99	0.32	0.53	FALSE
6	Adipose	Ube2s	mRNA stability	ENSRNOG00000016930	0.09	0.05	top1	1	0.06	9.6e-07	-5.6	5.6	2.6e-08	-0.99	0.40	0.58	FALSE
7	BLA	Ppp6r1	gene expression	ENSRNOG00000018090	0.08	0.04	blup	1460	0.05	1.6e-03	-5.2	5.5	4.3e-08	-0.99	0.38	0.50	FALSE
8	BLA	Fam71e2	gene expression	ENSRNOG00000033173	0.12	0.07	top1	1	0.07	1.2e-04	-5.2	-5.2	2.0e-07	0.99	0.10	0.04	FALSE
9	BLA	Epn1	intron excision ratio	chr1:68744817:68744951	0.17	0.04	top1	1	0.04	4.0e-03	-5.2	5.2	2.0e-07	-0.98	0.08	0.04	FALSE
10	BLA	Epn1	intron excision ratio	chr1:68744820:68744951	0.18	0.04	top1	1	0.04	4.2e-03	-5.2	-5.2	2.0e-07	0.98	0.08	0.04	FALSE
11	BLA	Ube2s	mRNA stability	ENSRNOG00000016930	0.07	0.05	top1	1	0.05	1.1e-03	-5.2	5.2	1.7e-07	-0.99	0.06	0.04	FALSE
12	BLA	Rdh13	mRNA stability	ENSRNOG00000027919	0.16	0.08	top1	1	0.08	3.6e-05	-5.3	5.3	9.7e-08	-1.00	0.09	0.05	FALSE
13	BLA	Nat14	mRNA stability	ENSRNOG00000067958	0.07	0.02	top1	1	0.02	4.6e-02	-5.2	5.2	2.0e-07	-0.99	0.07	0.04	FALSE
14	Brain	Leng9	alternative TSS	ENSRNOT00000116488	0.02	0.02	blup	1701	0.02	3.8e-03	-4.7	-5.1	2.8e-07	0.96	0.54	0.34	FALSE
15	Brain	Ccdc106	gene expression	ENSRNOG00000015997	0.06	0.07	enet	68	0.07	1.9e-07	-5.2	-5.2	1.7e-07	0.96	0.69	0.31	FALSE
16	Brain	Rpl28	gene expression	ENSRNOG00000017127	0.06	0.06	top1	1	0.06	2.8e-06	-5.6	-5.6	2.5e-08	0.97	0.35	0.52	FALSE
17	Brain	Kmt5c	gene expression	ENSRNOG00000017508	0.09	0.11	blup	1497	0.11	1.6e-10	-5.2	5.5	3.5e-08	-0.99	0.37	0.63	FALSE
18	Brain	Hspbp1	gene expression	ENSRNOG00000017795	0.03	0.03	top1	1	0.03	5.3e-04	-5.3	5.3	1.2e-07	-0.99	0.06	0.03	FALSE
19	Brain	Rdh13	gene expression	ENSRNOG00000027919	0.04	0.04	blup	1555	0.05	3.6e-05	-5.7	5.4	7.4e-08	-0.99	0.50	0.50	FALSE
20	Brain	Tnnt1	gene expression	ENSRNOG00000028041	0.24	0.25	blup	1547	0.32	9.1e-30	-5.7	5.3	9.6e-08	-0.98	0.44	0.56	FALSE
21	Brain	Fam71e2	gene expression	ENSRNOG00000033173	0.09	0.03	blup	1505	0.06	1.2e-06	-5.7	-5.4	6.3e-08	0.92	0.34	0.66	FALSE
22	Brain	NA	gene expression	ENSRNOG00000050348	0.08	0.08	blup	1717	0.10	1.9e-09	-5.7	-5.3	1.2e-07	0.99	0.42	0.58	FALSE
23	Brain	Tmem86b	gene expression	ENSRNOG00000064667	0.03	0.00	enet	123	0.01	2.1e-02	-5.2	5.4	8.4e-08	-0.98	0.30	0.40	FALSE
24	Brain	Ttyh1	isoform ratio	ENSRNOT00000106376	0.15	0.17	enet	29	0.18	1.3e-16	-4.7	5.1	2.7e-07	-0.95	0.96	0.04	FALSE
25	Brain	Epn1	intron excision ratio	chr1:68757388:68760368	0.04	0.03	blup	1989	0.03	7.0e-04	-5.2	5.3	1.0e-07	-0.99	0.48	0.50	FALSE
26	Brain	Kmt5c	intron excision ratio	chr1:69103923:69104463	0.05	0.05	blup	1497	0.05	2.7e-05	-5.7	5.6	2.6e-08	-0.98	0.37	0.63	FALSE
27	Brain	Kmt5c	intron excision ratio	chr1:69104572:69104912	0.02	0.02	top1	1	0.02	8.7e-03	-5.7	-5.7	1.1e-08	0.98	0.05	0.04	FALSE
28	Brain	Kmt5c	intron excision ratio	chr1:69104700:69104912	0.02	0.02	top1	1	0.02	2.6e-03	-5.7	5.7	1.1e-08	-0.98	0.05	0.05	FALSE
29	Brain	Brsk1	intron excision ratio	chr1:69155999:69158065	0.02	0.02	top1	1	0.02	1.0e-02	-5.6	5.6	2.5e-08	-0.98	0.05	0.03	FALSE
30	Brain	Brsk1	intron excision ratio	chr1:69155999:69158069	0.02	0.02	top1	1	0.02	4.0e-03	-5.6	-5.6	2.5e-08	0.98	0.05	0.04	FALSE
31	Brain	Lair1	intron excision ratio	chr1:70184913:70185336	0.06	0.05	blup	1689	0.06	3.0e-06	-5.6	-5.4	6.2e-08	0.99	0.48	0.52	FALSE
32	Brain	Lair1	intron excision ratio	chr1:70184913:70187858	0.06	0.05	blup	1689	0.06	1.9e-06	-5.6	5.5	4.2e-08	-1.00	0.43	0.57	FALSE
33	Brain	Ube2s	mRNA stability	ENSRNOG00000016930	0.02	0.02	blup	1511	0.03	2.0e-03	-4.7	5.2	2.6e-07	-0.97	0.47	0.38	FALSE
34	Brain	Tnni3	mRNA stability	ENSRNOG00000018250	0.03	0.03	enet	99	0.03	3.7e-04	-5.7	-5.7	1.6e-08	0.99	0.46	0.52	FALSE
35	Brain	Rdh13	mRNA stability	ENSRNOG00000027919	0.11	0.12	top1	1	0.12	4.3e-11	-5.7	5.7	9.3e-09	-0.99	0.26	0.74	FALSE
36	Brain	Nat14	mRNA stability	ENSRNOG00000067958	0.10	0.15	top1	1	0.15	1.2e-13	-5.3	5.3	1.2e-07	-0.99	0.74	0.26	FALSE
37	Eye	Ptprh	gene expression	ENSRNOG00000058906	0.49	-0.02	lasso	15	0.14	4.0e-03	-5.6	5.2	1.9e-07	0.74	0.32	0.26	FALSE
38	Eye	Rdh13	intron excision ratio	chr1:69392560:69395960	0.30	0.18	lasso	17	0.19	7.3e-04	-5.3	-5.3	9.7e-08	0.99	0.36	0.34	FALSE
39	IL	Tnni3	gene expression	ENSRNOG00000018250	0.45	0.01	enet	30	0.26	6.1e-07	-4.7	-5.1	2.7e-07	0.95	0.43	0.06	FALSE
40	IL	Fam71e2	gene expression	ENSRNOG00000033173	0.14	0.01	blup	1492	0.07	1.1e-02	-5.1	-5.5	3.5e-08	0.99	0.32	0.35	FALSE
41	LHb	Kmt5c	gene expression	ENSRNOG00000017508	0.19	0.13	top1	1	0.13	4.7e-04	-5.7	5.7	1.1e-08	-0.99	0.08	0.07	FALSE
42	LHb	Dnaaf3	gene expression	ENSRNOG00000038600	0.32	0.15	top1	1	0.15	2.0e-04	-5.6	5.6	2.5e-08	-0.99	0.11	0.09	FALSE
43	LHb	Lilrb3	gene expression	ENSRNOG00000046683	0.23	0.08	blup	1646	0.15	1.7e-04	-4.6	5.1	3.0e-07	-0.96	0.59	0.36	FALSE
44	LHb	Rdh13	mRNA stability	ENSRNOG00000027919	0.23	0.07	blup	1530	0.12	1.0e-03	-5.1	5.6	1.6e-08	-0.99	0.38	0.50	FALSE
45	Liver	Hspbp1	gene expression	ENSRNOG00000017795	0.05	0.02	top1	1	0.02	4.0e-03	-5.3	5.3	9.7e-08	-0.99	0.09	0.05	FALSE
46	Liver	Fam71e2	gene expression	ENSRNOG00000033173	0.02	0.01	top1	1	0.01	2.9e-02	-5.3	-5.3	9.2e-08	0.99	0.05	0.03	FALSE
47	Liver	Lilrb3	gene expression	ENSRNOG00000046683	0.30	0.36	lasso	17	0.36	6.8e-42	-4.6	5.3	1.3e-07	0.85	0.99	0.01	TRUE
48	Liver	Nat14	gene expression	ENSRNOG00000067958	0.05	0.03	lasso	3	0.03	1.2e-04	-2.6	5.3	1.4e-07	-0.14	0.42	0.53	FALSE
49	Liver	NA	isoform ratio	ENSRNOT00000101904	0.02	0.00	blup	1478	0.01	6.7e-02	-5.6	5.5	4.6e-08	-0.99	0.33	0.46	FALSE
50	Liver	NA	isoform ratio	ENSRNOT00000114704	0.02	0.00	blup	1478	0.01	7.3e-02	-5.6	-5.4	7.8e-08	0.98	0.33	0.34	FALSE
51	Liver	Lilrb3	intron excision ratio	chr1:69931288:69931364	0.02	0.00	blup	1674	0.01	5.6e-02	-4.8	5.2	1.7e-07	-0.97	0.42	0.23	FALSE
52	Liver	Ptprh	intron excision ratio	chr1:69258809:69262888	0.04	0.02	blup	1455	0.03	3.7e-04	-5.6	5.4	7.1e-08	-0.99	0.36	0.63	FALSE
53	Liver	Ube2s	mRNA stability	ENSRNOG00000016930	0.06	0.06	top1	1	0.06	1.7e-07	-5.2	5.2	2.0e-07	-0.99	0.80	0.17	FALSE
54	NAcc	Tnnt1	gene expression	ENSRNOG00000028041	0.13	0.09	blup	1531	0.09	4.0e-03	-5.6	5.6	2.6e-08	-1.00	0.35	0.38	FALSE
55	NAcc	Fam71e2	gene expression	ENSRNOG00000033173	0.22	0.05	blup	1492	0.12	1.5e-03	-5.4	-5.6	2.6e-08	0.96	0.34	0.51	FALSE
56	NAcc	Rdh13	mRNA stability	ENSRNOG00000027919	0.31	0.21	enet	9	0.25	2.2e-06	-5.7	5.8	5.2e-09	-0.99	0.42	0.58	TRUE
57	NAcc2	Rdh13	gene expression	ENSRNOG00000027919	0.27	0.18	top1	1	0.18	6.3e-10	-5.3	5.3	9.7e-08	-0.99	0.76	0.23	FALSE
58	NAcc2	Tnnt1	gene expression	ENSRNOG00000028041	0.06	-0.01	blup	1547	0.00	4.5e-01	-5.2	5.6	1.9e-08	-0.99	0.32	0.41	FALSE
59	NAcc2	Fam71e2	gene expression	ENSRNOG00000033173	0.11	0.04	top1	1	0.04	2.4e-03	-5.2	-5.2	1.7e-07	0.99	0.09	0.04	FALSE
60	NAcc2	NA	gene expression	ENSRNOG00000047204	0.09	0.01	blup	1461	0.02	2.3e-02	-5.6	5.7	1.5e-08	-0.97	0.31	0.49	FALSE
61	NAcc2	Leng9	intron excision ratio	chr1:70036341:70037702	0.06	0.01	top1	1	0.01	6.8e-02	-5.7	5.7	1.1e-08	-0.97	0.07	0.04	FALSE
62	NAcc2	Rdh13	mRNA stability	ENSRNOG00000027919	0.15	0.08	top1	1	0.08	2.6e-05	-5.3	5.3	9.7e-08	-0.99	0.15	0.06	FALSE
63	NAcc2	Ttyh1	mRNA stability	ENSRNOG00000032699	0.06	0.03	top1	1	0.03	1.3e-02	-5.6	-5.6	2.0e-08	0.99	0.07	0.04	FALSE
64	OFC	Rpl28	gene expression	ENSRNOG00000017127	0.16	0.03	blup	1496	0.06	1.8e-02	-5.7	-5.4	6.0e-08	0.99	0.29	0.28	FALSE
65	PL	Syt5	gene expression	ENSRNOG00000018217	0.40	0.17	enet	16	0.33	9.8e-09	-4.4	5.2	2.6e-07	-0.97	0.58	0.42	FALSE
66	PL	Rdh13	mRNA stability	ENSRNOG00000027919	0.25	0.20	blup	1530	0.25	9.9e-07	-5.7	5.4	5.4e-08	-0.99	0.49	0.50	FALSE
67	PL2	Syt5	gene expression	ENSRNOG00000018217	0.39	0.26	enet	290	0.30	1.8e-16	-4.3	5.3	9.6e-08	-0.98	0.92	0.09	FALSE
68	PL2	Rdh13	gene expression	ENSRNOG00000027919	0.20	0.11	enet	459	0.13	8.8e-08	-5.3	5.1	3.0e-07	-0.97	0.50	0.50	FALSE
69	PL2	Fam71e2	gene expression	ENSRNOG00000033173	0.13	0.07	top1	1	0.07	1.0e-04	-5.2	-5.2	2.0e-07	0.99	0.09	0.04	FALSE
70	PL2	Dnaaf3	gene expression	ENSRNOG00000038600	0.05	0.03	top1	1	0.03	7.6e-03	-5.6	-5.6	2.5e-08	0.98	0.06	0.04	FALSE
71	PL2	NA	isoform ratio	ENSRNOT00000114704	0.09	0.01	top1	1	0.01	6.1e-02	-5.6	5.6	2.5e-08	-1.00	0.06	0.04	FALSE
72	PL2	Rdh13	mRNA stability	ENSRNOG00000027919	0.31	0.17	enet	212	0.19	1.6e-10	-5.3	5.4	6.3e-08	-0.95	0.36	0.64	FALSE
73	PL2	Ttyh1	mRNA stability	ENSRNOG00000032699	0.12	0.06	blup	1691	0.07	8.1e-05	-4.6	-5.1	3.2e-07	0.96	0.68	0.31	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.