Hub : Traits : Bone: periosteal estimation : →

chr7:128,200,675-130,977,246

Trait: Bone: periosteal estimation

Best TWAS P=3.98844e-08 · Best GWAS P=1.288389e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Prph	gene expression	ENSRNOG00000052880	0.09	0.07	top1	1	0.07	5.7e-08	5.2	-5.2	2.1e-07	-0.98	0.25	0.74	FALSE
2	Adipose	Tuba1b	gene expression	ENSRNOG00000053468	0.06	0.04	top1	1	0.04	1.4e-05	5.2	-5.2	2.6e-07	-0.99	0.25	0.56	FALSE
3	Adipose	NA	gene expression	ENSRNOG00000067620	0.03	0.03	top1	1	0.03	6.1e-04	5.2	-5.2	2.1e-07	-0.98	0.07	0.07	FALSE
4	Adipose	NA	gene expression	ENSRNOG00000069732	0.02	0.01	top1	1	0.01	4.3e-02	5.2	5.2	2.1e-07	0.99	0.04	0.03	FALSE
5	Adipose	Asb8	mRNA stability	ENSRNOG00000010099	0.13	0.17	lasso	5	0.17	1.9e-18	5.2	-5.2	2.5e-07	0.94	0.63	0.37	TRUE
6	Adipose	Hdac7	mRNA stability	ENSRNOG00000055597	0.18	0.16	enet	238	0.17	5.4e-18	5.1	-5.2	1.6e-07	-0.79	0.70	0.30	TRUE
7	Adipose	Pfkm	mRNA stability	ENSRNOG00000057988	0.11	0.12	lasso	13	0.13	7.9e-14	5.1	-5.1	3.2e-07	-0.94	0.65	0.35	FALSE
8	BLA	Slc48a1	gene expression	ENSRNOG00000053196	0.25	0.22	enet	17	0.23	2.5e-12	5.1	5.2	1.8e-07	0.74	0.68	0.32	FALSE
9	BLA	Tmem106c	gene expression	ENSRNOG00000053269	0.24	0.30	lasso	22	0.30	1.3e-16	5.0	5.2	2.3e-07	0.90	0.66	0.34	FALSE
10	BLA	Adcy6	gene expression	ENSRNOG00000054757	0.13	0.13	enet	59	0.14	6.5e-08	5.1	5.2	1.9e-07	0.94	0.60	0.40	FALSE
11	BLA	Tuba1b	isoform ratio	ENSRNOT00000081355	0.88	0.68	enet	82	0.73	8.5e-56	4.9	5.1	3.5e-07	0.99	0.54	0.46	FALSE
12	BLA	Cacnb3	isoform ratio	ENSRNOT00000081206	0.07	0.05	top1	1	0.05	1.1e-03	5.2	-5.2	2.4e-07	-0.98	0.08	0.06	FALSE
13	BLA	Cacnb3	isoform ratio	ENSRNOT00000097309	0.08	0.06	top1	1	0.06	4.6e-04	5.2	5.2	2.4e-07	0.98	0.10	0.08	FALSE
14	BLA	Rapgef3	isoform ratio	ENSRNOT00000096691	0.06	0.03	top1	1	0.03	7.7e-03	5.1	5.1	2.9e-07	0.94	0.10	0.04	FALSE
15	BLA	Tuba1b	intron excision ratio	chr7:130092476:130093543	0.15	0.11	top1	1	0.11	2.9e-06	5.1	5.1	3.4e-07	0.99	0.31	0.55	FALSE
16	BLA	Tuba1b	intron excision ratio	chr7:130115057:130116812	0.08	0.05	lasso	4	0.08	4.6e-05	5.0	-5.3	1.5e-07	-0.27	0.48	0.48	TRUE
17	BLA	Fkbp11	mRNA stability	ENSRNOG00000070637	0.05	0.03	enet	11	0.06	3.2e-04	5.0	-5.5	4.0e-08	-0.81	0.58	0.37	TRUE
18	Brain	Tuba1b	gene expression	ENSRNOG00000053468	0.13	0.16	enet	26	0.16	1.2e-14	5.0	5.1	3.4e-07	0.98	0.47	0.53	FALSE
19	Brain	Cacnb3	gene expression	ENSRNOG00000054274	0.24	0.38	top1	1	0.38	7.4e-37	5.2	5.2	2.3e-07	0.98	0.40	0.60	FALSE
20	Brain	Adcy6	gene expression	ENSRNOG00000054757	0.07	0.11	top1	1	0.11	5.3e-10	5.2	5.2	1.8e-07	0.98	0.35	0.65	FALSE
21	Brain	NA	gene expression	ENSRNOG00000061607	0.18	0.20	lasso	22	0.20	2.8e-18	4.8	5.1	2.8e-07	0.97	0.62	0.38	FALSE
22	Brain	Tuba1b	isoform ratio	ENSRNOT00000081355	0.86	0.70	enet	217	0.72	1.6e-94	5.0	5.1	2.9e-07	0.98	0.48	0.52	FALSE
23	Brain	Tuba1b	isoform ratio	ENSRNOT00000083156	0.88	0.71	lasso	44	0.73	6.2e-99	5.0	-5.2	1.9e-07	-0.98	0.48	0.52	FALSE
24	Brain	Kmt2d	isoform ratio	ENSRNOT00000077502	0.28	0.29	lasso	17	0.30	1.3e-28	5.1	5.2	2.3e-07	1.00	0.50	0.50	FALSE
25	Brain	Kmt2d	isoform ratio	ENSRNOT00000111826	0.29	0.29	lasso	17	0.30	1.3e-28	5.1	-5.2	2.3e-07	-1.00	0.50	0.50	FALSE
26	Brain	Ccdc65	intron excision ratio	chr7:129864024:129864788	0.12	0.15	top1	1	0.15	1.2e-13	5.2	-5.2	1.8e-07	-0.99	0.33	0.67	FALSE
27	Brain	Ccdc65	intron excision ratio	chr7:129864926:129868238	0.11	0.15	lasso	51	0.15	7.2e-14	5.2	5.2	2.1e-07	0.99	0.54	0.46	FALSE
28	Brain	Kansl2	intron excision ratio	chr7:129685147:129685358	0.02	0.02	top1	1	0.02	8.4e-03	5.3	5.3	1.4e-07	0.98	0.06	0.04	FALSE
29	Brain	Fkbp11	mRNA stability	ENSRNOG00000054775	0.81	0.72	top1	1	0.72	3.4e-94	5.2	-5.2	2.3e-07	-0.99	0.36	0.64	FALSE
30	LHb	Zfp641	gene expression	ENSRNOG00000032447	0.23	0.12	lasso	6	0.14	2.9e-04	5.0	5.2	2.5e-07	0.97	0.60	0.37	FALSE
31	LHb	Spats2	gene expression	ENSRNOG00000052307	0.20	0.16	top1	1	0.16	1.6e-04	5.1	-5.1	3.2e-07	-0.98	0.07	0.10	FALSE
32	Liver	Tuba1c	gene expression	ENSRNOG00000021438	0.04	0.02	enet	7	0.02	2.1e-03	5.2	5.1	2.9e-07	0.96	0.45	0.46	FALSE
33	Liver	NA	gene expression	ENSRNOG00000063058	0.05	0.06	top1	1	0.06	5.1e-07	5.1	-5.1	3.0e-07	-0.96	0.47	0.41	FALSE
34	Liver	Tmem106c	intron excision ratio	chr7:129091964:129092370	0.24	0.29	lasso	57	0.30	1.2e-33	5.0	5.1	2.7e-07	0.93	0.66	0.34	FALSE
35	Liver	Tmem106c	mRNA stability	ENSRNOG00000053269	0.12	0.08	enet	137	0.08	1.2e-09	5.0	5.1	3.1e-07	0.94	0.66	0.34	FALSE
36	NAcc	Tuba1b	alternative polyA	ENSRNOT00000081355	0.05	0.03	top1	1	0.03	4.5e-03	5.1	5.1	3.1e-07	0.98	0.04	0.04	FALSE
37	NAcc	Cacnb3	gene expression	ENSRNOG00000054274	0.04	0.03	top1	1	0.03	1.9e-03	5.3	5.3	1.3e-07	0.98	0.07	0.04	FALSE
38	NAcc	Tuba1b	isoform ratio	ENSRNOT00000081355	0.89	0.57	enet	26	0.60	1.3e-54	5.1	5.1	3.4e-07	0.99	0.53	0.47	FALSE
39	NAcc	Ccdc65	mRNA stability	ENSRNOG00000058916	0.04	0.06	top1	1	0.06	5.6e-05	5.1	-5.1	2.7e-07	-0.99	0.09	0.07	FALSE
40	NAcc	NA	mRNA stability	ENSRNOG00000061607	0.04	0.02	top1	1	0.02	2.1e-02	5.3	-5.3	1.3e-07	-0.99	0.04	0.05	FALSE
41	OFC	Adcy6	gene expression	ENSRNOG00000054757	0.34	0.22	top1	1	0.22	6.3e-06	5.2	5.2	2.1e-07	0.98	0.11	0.09	FALSE
42	PL	Ccdc65	intron excision ratio	chr7:129858008:129863855	0.08	0.09	enet	46	0.09	1.7e-07	5.3	-5.1	3.1e-07	-0.99	0.60	0.40	FALSE
43	PL	Kmt2d	mRNA stability	ENSRNOG00000061499	0.08	0.07	top1	1	0.07	3.4e-06	5.2	5.2	2.1e-07	0.99	0.27	0.56	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.