Best TWAS P=1.592055e-09 · Best GWAS P=2.777223e-10 conditioned to 0.02945335
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Supt3h | alternative polyA | ENSRNOT00000097089 | 0.05 | 0.05 | enet | 37 | 0.06 | 6.4e-07 | -5.7 | 5.7 | 9.1e-09 | -0.85 | 0.55 | 0.44 | FALSE |
2 | Adipose | Supt3h | isoform ratio | ENSRNOT00000097089 | 0.07 | 0.06 | blup | 1700 | 0.06 | 1.9e-07 | -5.7 | 6.0 | 1.7e-09 | -0.87 | 0.45 | 0.55 | FALSE |
3 | Brain | Supt3h | gene expression | ENSRNOG00000020153 | 0.05 | 0.01 | blup | 1704 | 0.03 | 4.4e-04 | -6.3 | -6.0 | 1.6e-09 | 0.86 | 0.25 | 0.70 | TRUE |
4 | Liver | Slc29a1 | gene expression | ENSRNOG00000019752 | 0.08 | 0.04 | blup | 1996 | 0.05 | 2.3e-06 | -3.8 | 5.2 | 1.7e-07 | -0.66 | 0.42 | 0.58 | FALSE |
5 | Liver | Supt3h | gene expression | ENSRNOG00000020153 | 0.03 | 0.02 | top1 | 1 | 0.02 | 2.8e-03 | -5.7 | 5.7 | 1.2e-08 | -0.84 | 0.05 | 0.03 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.