Hub : Traits : length :

chr7:129,497,169-132,411,050

Best TWAS P=5.423934e-08 · Best GWAS P=6.130186e-07 conditioned to 9.226272e-85

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Slc11a2	mRNA stability	ENSRNOG00000019550	0.28	0.09	blup	1546	0.17	2.0e-18	-4.8	-5.2	2.0e-07	0.92	0.43	0.57	FALSE
2	BLA	Csrnp2	gene expression	ENSRNOG00000019653	0.06	0.01	blup	1591	0.02	4.5e-02	-4.6	5.2	2.2e-07	-0.83	0.38	0.36	FALSE
3	Brain	Dip2b	mRNA stability	ENSRNOG00000056106	0.09	0.04	lasso	3	0.06	4.2e-06	4.5	5.2	2.5e-07	-0.87	0.56	0.44	FALSE
4	IL	Dip2b	mRNA stability	ENSRNOG00000056106	0.18	0.07	blup	1360	0.12	7.7e-04	4.7	5.1	3.2e-07	-0.83	0.50	0.39	FALSE
5	NAcc	Slc11a2	alternative polyA	ENSRNOT00000026531	0.47	0.13	enet	13	0.16	2.1e-04	4.6	5.2	2.0e-07	-0.85	0.53	0.46	FALSE
6	NAcc	Slc11a2	alternative polyA	ENSRNOT00000086751	0.50	0.14	enet	14	0.17	1.0e-04	4.6	-5.2	1.6e-07	0.86	0.52	0.46	FALSE
7	NAcc	Slc11a2	alternative polyA	ENSRNOT00000026531	0.44	0.16	enet	12	0.16	1.7e-04	4.6	5.2	2.4e-07	-0.83	0.54	0.45	FALSE
8	NAcc	Slc11a2	alternative polyA	ENSRNOT00000081327	0.48	0.17	enet	11	0.20	3.5e-05	4.6	-5.2	1.9e-07	0.85	0.53	0.46	FALSE
9	NAcc2	NA	gene expression	ENSRNOG00000069802	0.10	0.09	enet	34	0.12	5.5e-07	-4.6	-5.4	6.5e-08	0.55	0.55	0.44	TRUE
10	OFC	NA	gene expression	ENSRNOG00000065389	0.17	0.11	lasso	3	0.13	4.6e-04	-4.8	-5.2	2.3e-07	0.92	0.35	0.30	FALSE
11	OFC	Slc11a2	isoform ratio	ENSRNOT00000026531	0.31	0.17	enet	11	0.24	2.3e-06	-4.8	5.2	2.5e-07	-0.90	0.48	0.50	FALSE
12	OFC	Atf1	mRNA stability	ENSRNOG00000061088	0.20	0.09	enet	13	0.11	1.4e-03	4.6	5.1	3.1e-07	-0.91	0.47	0.43	FALSE
13	PL2	Tuba1b	alternative TSS	ENSRNOT00000110990	0.13	0.06	enet	3	0.09	1.3e-05	4.7	-5.3	1.5e-07	0.53	0.52	0.47	FALSE
14	PL2	Slc11a2	gene expression	ENSRNOG00000019550	0.09	0.04	blup	1550	0.05	6.9e-04	4.5	-5.2	2.0e-07	0.83	0.53	0.44	FALSE
15	PL2	Csrnp2	gene expression	ENSRNOG00000019653	0.24	0.11	enet	117	0.15	1.7e-08	-4.7	5.4	5.4e-08	-0.83	0.48	0.52	TRUE
16	PL2	NA	gene expression	ENSRNOG00000065389	0.15	0.06	enet	109	0.07	7.3e-05	4.5	-5.3	1.5e-07	0.86	0.54	0.46	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.