Hub : Traits : dissection: UMAP 1 of all traits : ← →

chr5:60,651,052-64,651,466

Best TWAS P=4.029222e-09 · Best GWAS P=7.912584e-09 conditioned to 8.593466e-64

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Tmeff1	alternative polyA	ENSRNOT00000119982	0.03	0.01	enet	34	0.01	5.5e-02	-4.9	5.5	3.6e-08	0.58	0.29	0.33	TRUE
2	Adipose	Stx17	gene expression	ENSRNOG00000005801	0.62	0.31	lasso	19	0.35	9.9e-40	5.4	-5.2	2.4e-07	-0.63	0.15	0.85	FALSE
3	Adipose	Alg2	gene expression	ENSRNOG00000006369	0.64	0.44	enet	118	0.44	6.8e-54	5.6	5.5	3.9e-08	0.61	0.28	0.72	FALSE
4	Adipose	Tmeff1	isoform ratio	ENSRNOT00000065775	0.12	0.04	top1	1	0.04	1.8e-05	5.3	5.3	1.5e-07	0.64	0.30	0.28	FALSE
5	Adipose	Anks6	mRNA stability	ENSRNOG00000023309	0.04	0.01	top1	1	0.01	1.7e-02	-5.2	-5.2	2.1e-07	-0.55	0.08	0.03	FALSE
6	BLA	Alg2	gene expression	ENSRNOG00000006369	0.77	0.38	lasso	13	0.42	1.8e-24	5.6	5.5	3.3e-08	0.61	0.42	0.58	FALSE
7	BLA	Cavin4	gene expression	ENSRNOG00000008027	0.77	0.30	lasso	32	0.32	2.1e-17	5.4	5.2	1.6e-07	-0.65	0.37	0.63	TRUE
8	BLA	Tmeff1	gene expression	ENSRNOG00000008034	0.08	0.03	top1	1	0.04	5.6e-03	5.2	5.2	2.0e-07	0.51	0.07	0.04	FALSE
9	BLA	Anks6	intron excision ratio	chr5:61319844:61320495	0.07	0.07	blup	2422	0.08	2.9e-05	-4.4	5.1	2.7e-07	0.56	0.60	0.40	FALSE
10	Brain	Alg2	gene expression	ENSRNOG00000006369	0.46	0.50	enet	83	0.52	1.4e-56	5.6	5.3	9.0e-08	0.60	0.31	0.69	FALSE
11	Brain	Pgap4	gene expression	ENSRNOG00000006800	0.19	0.06	enet	178	0.10	7.5e-10	5.0	-5.2	1.7e-07	-0.85	0.17	0.83	TRUE
12	Brain	Cavin4	gene expression	ENSRNOG00000008027	0.51	0.37	lasso	7	0.38	8.8e-37	5.4	5.4	6.8e-08	0.65	0.32	0.68	FALSE
13	Brain	Tmeff1	gene expression	ENSRNOG00000008034	0.39	0.32	lasso	19	0.33	5.0e-31	5.4	5.3	8.9e-08	0.64	0.35	0.65	FALSE
14	Brain	Msantd3	gene expression	ENSRNOG00000008159	0.03	0.02	lasso	20	0.03	1.7e-03	5.3	5.4	5.4e-08	0.55	0.41	0.45	FALSE
15	Brain	Tex10	intron excision ratio	chr5:62798394:62801471	0.03	0.02	top1	1	0.02	9.8e-03	5.2	-5.2	2.0e-07	-0.53	0.06	0.04	TRUE
16	Brain	Cavin4	mRNA stability	ENSRNOG00000008027	0.06	0.03	enet	15	0.03	3.9e-04	5.3	5.3	1.1e-07	0.63	0.46	0.53	FALSE
17	Eye	Alg2	gene expression	ENSRNOG00000006369	0.30	0.11	top1	1	0.11	8.7e-03	5.7	5.7	1.3e-08	0.57	0.13	0.06	FALSE
18	Eye	Tgfbr1	intron excision ratio	chr5:61691098:61698938	0.29	0.16	top1	1	0.16	2.2e-03	5.4	-5.4	7.9e-08	-0.58	0.13	0.06	FALSE
19	Eye	Tgfbr1	intron excision ratio	chr5:61699654:61701423	0.30	0.15	lasso	17	0.17	1.4e-03	5.4	5.4	7.9e-08	-0.62	0.39	0.32	FALSE
20	IL	Alg2	gene expression	ENSRNOG00000006369	0.67	0.31	top1	1	0.31	4.2e-08	5.2	5.2	1.6e-07	0.56	0.38	0.20	FALSE
21	IL	Tmeff1	gene expression	ENSRNOG00000008034	0.26	0.07	top1	1	0.07	1.0e-02	5.2	5.2	2.2e-07	0.64	0.09	0.05	FALSE
22	IL	Anks6	gene expression	ENSRNOG00000023309	0.34	0.21	enet	8	0.24	1.5e-06	5.2	-5.3	1.4e-07	0.37	0.69	0.31	FALSE
23	Liver	Zfp189	alternative TSS	ENSRNOT00000100201	0.04	0.01	blup	2618	0.01	7.4e-03	5.1	5.2	2.3e-07	0.82	0.65	0.20	FALSE
24	Liver	Acnat1	intron excision ratio	chr5:63765256:63766255	0.53	0.45	lasso	16	0.49	3.1e-62	4.8	5.1	3.1e-07	0.76	0.86	0.14	TRUE
25	Liver	NA	mRNA stability	ENSRNOG00000068816	0.34	0.23	enet	170	0.25	4.4e-27	4.7	-5.2	2.3e-07	-0.75	0.85	0.15	FALSE
26	NAcc	Cavin4	gene expression	ENSRNOG00000008027	0.54	0.27	blup	1762	0.30	2.3e-07	4.9	5.2	1.7e-07	0.67	0.50	0.50	FALSE
27	NAcc	Tmeff1	gene expression	ENSRNOG00000008034	0.53	0.29	enet	9	0.30	1.5e-07	5.1	5.3	9.6e-08	0.58	0.52	0.48	FALSE
28	NAcc2	Stx17	gene expression	ENSRNOG00000005801	0.73	0.26	enet	63	0.26	1.5e-14	5.4	-5.1	3.1e-07	-0.64	0.23	0.77	FALSE
29	NAcc2	Alg2	gene expression	ENSRNOG00000006369	0.58	0.37	enet	358	0.39	1.7e-22	5.0	5.2	1.6e-07	0.56	0.42	0.58	TRUE
30	NAcc2	Plppr1	gene expression	ENSRNOG00000007575	0.06	0.03	blup	2811	0.04	1.8e-03	4.9	-5.5	3.4e-08	-0.77	0.58	0.32	FALSE
31	NAcc2	Cavin4	gene expression	ENSRNOG00000008027	0.53	0.42	lasso	3	0.45	2.4e-26	5.2	5.5	4.6e-08	0.62	0.35	0.65	FALSE
32	NAcc2	Tmeff1	gene expression	ENSRNOG00000008034	0.47	0.31	lasso	23	0.32	1.5e-17	5.4	5.4	6.7e-08	0.65	0.40	0.60	FALSE
33	NAcc2	Anks6	intron excision ratio	chr5:61319162:61320495	0.05	0.03	top1	1	0.04	5.6e-03	5.1	-5.1	2.9e-07	-0.55	0.10	0.04	TRUE
34	OFC	Stx17	gene expression	ENSRNOG00000005801	0.71	0.20	lasso	6	0.20	1.5e-05	5.3	-5.3	1.4e-07	-0.66	0.23	0.76	FALSE
35	OFC	Alg2	gene expression	ENSRNOG00000006369	0.65	0.26	lasso	13	0.26	5.8e-07	5.6	5.9	4.0e-09	0.59	0.37	0.63	TRUE
36	OFC	Cavin4	gene expression	ENSRNOG00000008027	0.24	0.11	lasso	3	0.14	3.3e-04	5.3	5.3	1.1e-07	0.66	0.41	0.49	FALSE
37	PL	Alg2	gene expression	ENSRNOG00000006369	0.83	0.57	top1	1	0.57	1.8e-16	5.4	5.4	6.0e-08	0.57	0.42	0.58	FALSE
38	PL	Cavin4	gene expression	ENSRNOG00000008027	0.46	0.30	top1	1	0.30	7.8e-08	5.2	5.2	1.8e-07	0.65	0.36	0.29	FALSE
39	PL	Anks6	intron excision ratio	chr5:61319162:61320495	0.16	0.11	blup	2747	0.12	8.7e-04	-4.1	-5.2	2.3e-07	-0.56	0.52	0.34	FALSE
40	PL2	Stx17	gene expression	ENSRNOG00000005801	0.66	0.40	lasso	6	0.42	9.9e-25	5.3	-5.2	1.9e-07	-0.61	0.18	0.82	FALSE
41	PL2	Alg2	gene expression	ENSRNOG00000006369	0.60	0.46	enet	247	0.46	7.6e-28	5.6	5.2	2.2e-07	0.57	0.43	0.57	FALSE
42	PL2	Cavin4	gene expression	ENSRNOG00000008027	0.40	0.29	lasso	25	0.30	6.1e-17	5.2	5.2	2.1e-07	0.63	0.44	0.56	FALSE
43	PL2	Tmeff1	gene expression	ENSRNOG00000008034	0.13	0.09	lasso	1	0.10	5.7e-06	5.2	5.2	2.1e-07	0.66	0.43	0.57	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.