Best TWAS P=4.819074e-08 · Best GWAS P=1.034094e-08 conditioned to 0.307939
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NAcc | Ptprm | gene expression | ENSRNOG00000011700 | 0.38 | 0.20 | top1 | 1 | 0.20 | 3.2e-05 | 5.5 | 5.5 | 4.8e-08 | 0.70 | 0.13 | 0.20 | TRUE |
| 2 | PL2 | Ptprm | mRNA stability | ENSRNOG00000011700 | 0.11 | 0.04 | enet | 120 | 0.04 | 3.5e-03 | -3.9 | 5.2 | 1.7e-07 | 0.51 | 0.40 | 0.18 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.