Best TWAS P=7.041065e-08 · Best GWAS P=4.768861e-08 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver | Rab11fip2 | gene expression | ENSRNOG00000009523 | 0.03 | 0.00 | blup | 2371 | 0.01 | 1.3e-02 | -4.1 | -5.2 | 2.4e-07 | 0.80 | 0.34 | 0.35 | FALSE |
| 2 | Liver | Cacul1 | isoform ratio | ENSRNOT00000050617 | 0.03 | 0.02 | top1 | 1 | 0.02 | 1.3e-03 | -5.1 | 5.1 | 2.8e-07 | -0.94 | 0.07 | 0.08 | FALSE |
| 3 | Liver | Cacul1 | mRNA stability | ENSRNOG00000009954 | 0.03 | 0.01 | top1 | 1 | 0.01 | 1.4e-02 | -5.4 | 5.4 | 7.0e-08 | -0.94 | 0.05 | 0.06 | TRUE |
| 4 | OFC | Rab11fip2 | mRNA stability | ENSRNOG00000009523 | 0.16 | 0.19 | top1 | 1 | 0.19 | 2.9e-05 | -5.2 | -5.2 | 1.6e-07 | 0.89 | 0.12 | 0.08 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.