Hub : Traits : tautz: manual_spc21 :

chr4:179,109,719-181,703,913

Best TWAS P=9.595495e-08 · Best GWAS P=1.756484e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ccdc91	alternative TSS	ENSRNOT00000108480	0.06	0.02	top1	1	0.02	2.0e-03	5.1	-5.1	3.2e-07	-0.99	0.06	0.04	FALSE
2	Adipose	Ccdc91	gene expression	ENSRNOG00000001847	0.37	0.34	enet	48	0.36	4.0e-41	5.1	-5.2	1.7e-07	-0.95	0.71	0.29	FALSE
3	Adipose	Ccdc91	isoform ratio	ENSRNOT00000119701	0.18	0.14	lasso	12	0.15	1.0e-16	5.0	-5.2	2.2e-07	-0.96	0.59	0.41	FALSE
4	Adipose	Ccdc91	intron excision ratio	chr4:180442699:180463528	0.18	0.15	blup	1622	0.15	2.8e-16	4.8	-5.2	2.6e-07	-0.99	0.61	0.39	FALSE
5	Adipose	Ccdc91	intron excision ratio	chr4:180442699:180468293	0.04	0.02	blup	1622	0.02	2.5e-03	5.1	-5.2	2.5e-07	-0.98	0.56	0.35	FALSE
6	Adipose	Ccdc91	intron excision ratio	chr4:180442699:180469217	0.26	0.20	enet	84	0.21	6.3e-23	4.8	5.1	2.9e-07	0.97	0.57	0.43	FALSE
7	Adipose	Ppfibp1	intron excision ratio	chr4:179916968:179919448	0.10	0.04	top1	1	0.04	3.6e-05	5.2	-5.2	2.4e-07	-0.96	0.17	0.33	FALSE
8	BLA	Far2	gene expression	ENSRNOG00000001851	0.06	0.05	top1	1	0.04	1.8e-03	5.1	5.1	3.2e-07	0.90	0.07	0.07	FALSE
9	Brain	Mrps35	intron excision ratio	chr4:179976408:179977982	0.04	0.01	blup	1441	0.01	2.2e-02	4.7	-5.1	3.1e-07	-0.98	0.52	0.41	FALSE
10	Eye	Mrps35	gene expression	ENSRNOG00000001842	0.77	0.27	lasso	36	0.33	5.9e-06	5.1	5.3	9.6e-08	0.99	0.54	0.40	TRUE
11	LHb	Mrps35	gene expression	ENSRNOG00000001842	0.57	0.45	lasso	5	0.49	2.4e-13	5.0	5.1	3.0e-07	0.99	0.49	0.51	FALSE
12	LHb	Mrps35	intron excision ratio	chr4:179972311:179987238	0.20	0.22	top1	1	0.22	6.2e-06	5.2	5.2	2.4e-07	0.98	0.10	0.09	FALSE
13	NAcc	Mrps35	gene expression	ENSRNOG00000001842	0.63	0.34	top1	1	0.34	1.6e-08	5.1	5.1	3.3e-07	0.98	0.34	0.32	FALSE
14	NAcc	Klhl42	gene expression	ENSRNOG00000001844	0.14	0.06	top1	1	0.06	2.0e-02	5.2	5.2	2.4e-07	0.98	0.08	0.05	FALSE
15	NAcc	NA	gene expression	ENSRNOG00000067947	0.27	0.14	top1	1	0.14	5.4e-04	5.2	5.2	2.4e-07	0.98	0.09	0.07	FALSE
16	NAcc2	Klhl42	gene expression	ENSRNOG00000001844	0.26	0.18	enet	30	0.20	2.6e-11	5.2	5.2	2.5e-07	0.96	0.56	0.44	FALSE
17	OFC	NA	gene expression	ENSRNOG00000067947	0.15	0.09	lasso	2	0.10	2.9e-03	5.2	5.3	9.7e-08	0.99	0.38	0.29	FALSE
18	OFC	Ppfibp1	intron excision ratio	chr4:179931877:179932266	0.19	0.08	enet	7	0.10	2.9e-03	5.2	-5.2	2.5e-07	-0.97	0.32	0.41	FALSE
19	OFC	Mrps35	mRNA stability	ENSRNOG00000001842	0.34	0.05	blup	1439	0.18	5.7e-05	4.9	5.1	3.2e-07	0.99	0.52	0.43	FALSE
20	PL	NA	gene expression	ENSRNOG00000067947	0.36	0.15	top1	1	0.15	1.9e-04	5.2	5.2	2.4e-07	0.98	0.10	0.07	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.