Best TWAS P=9.752704e-09 · Best GWAS P=5.27254e-07 conditioned to 0.3320922
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Nln | alternative polyA | ENSRNOT00000066925 | 0.14 | 0.04 | blup | 1007 | 0.04 | 6.1e-05 | -4.7 | -5.2 | 2.4e-07 | 0.95 | 0.39 | 0.60 | FALSE |
| 2 | Brain | Nln | gene expression | ENSRNOG00000011561 | 0.36 | 0.03 | blup | 1007 | 0.05 | 2.2e-05 | -4.7 | -5.7 | 9.8e-09 | 0.77 | 0.37 | 0.60 | TRUE |
| 3 | IL | Rgs7bp | gene expression | ENSRNOG00000013389 | 0.39 | 0.18 | enet | 4 | 0.20 | 1.3e-05 | -4.7 | -5.1 | 2.9e-07 | 0.95 | 0.51 | 0.46 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.