Best TWAS P=1.339977e-08 · Best GWAS P=3.789783e-06 conditioned to 0.143861
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | IL | NA | gene expression | ENSRNOG00000063115 | 0.28 | 0.04 | blup | 3054 | 0.05 | 0.02000 | -4.1 | -5.4 | 8.1e-08 | -0.62 | 0.43 | 0.36 | FALSE |
| 2 | PL | NA | gene expression | ENSRNOG00000063115 | 0.19 | 0.07 | blup | 3054 | 0.14 | 0.00035 | 4.0 | -5.5 | 4.0e-08 | -0.75 | 0.45 | 0.39 | FALSE |
| 3 | PL2 | Dsg2 | mRNA stability | ENSRNOG00000016526 | 0.17 | 0.05 | blup | 3564 | 0.06 | 0.00022 | 3.8 | 5.7 | 1.3e-08 | 0.61 | 0.60 | 0.22 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.