Best TWAS P=5.250556e-08 · Best GWAS P=4.090254e-08 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Supt3h | alternative polyA | ENSRNOT00000097089 | 0.05 | 0.05 | enet | 37 | 0.06 | 6.4e-07 | 5.3 | -5.3 | 1.1e-07 | -0.92 | 0.44 | 0.56 | FALSE |
2 | Adipose | Supt3h | isoform ratio | ENSRNOT00000097089 | 0.07 | 0.06 | blup | 1700 | 0.06 | 1.9e-07 | 5.3 | -5.4 | 5.3e-08 | -0.93 | 0.36 | 0.64 | TRUE |
3 | Brain | Supt3h | gene expression | ENSRNOG00000020153 | 0.05 | 0.01 | blup | 1704 | 0.03 | 4.4e-04 | 4.7 | 5.2 | 2.2e-07 | 0.88 | 0.40 | 0.53 | FALSE |
4 | Liver | Supt3h | gene expression | ENSRNOG00000020153 | 0.03 | 0.02 | top1 | 1 | 0.02 | 2.8e-03 | 5.3 | -5.3 | 9.8e-08 | -0.91 | 0.05 | 0.03 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.