Hub : Traits

dissection: UMAP 1 of all traits

Project: dissection

1353 significantly associated models · 231 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 149857704 153371149 13 4 7.0e-09 9.8e-09 1.0e+00 100 Tenm4 Aamdc Clns1a NA
2 1 169577644 171490581 7 1 6.5e-09 6.2e-09 1.0e+00 100 Pik3c2a
3 1 251447555 260518987 48 6 3.2e-57 4.8e-58 1.0e+00 100 Cacul1 Tectb Atrnl1 Ccdc186 Casp7 NA
4 3 91159360 93417804 5 1 1.2e-08 2.1e-08 1.0e+00 100 AABR07053185.1
5 3 105063132 108052408 7 1 6.9e-08 9.2e-08 2.9e-01 96 Ehd4
6 3 126160536 128707024 7 4 1.1e-12 1.3e-13 1.0e+00 100 Sptlc3 Tasp1 Esf1 AABR07054000.1
7 3 129554891 132898674 17 7 4.2e-21 2.9e-19 NaN NaN Kif16b Pcsk2 Rrbp1 Kat14 Dzank1 Sec23b Otor
8 5 60651052 64651466 13 7 4.0e-09 7.9e-09 8.6e-64 -754 Alg2 Pgap4 Cavin4 Tmeff1 Tex10 Anks6 Acnat1
9 6 24048319 29090273 51 9 7.4e-13 6.0e-13 1.0e+00 100 Ncoa1 Klhl29 Mapre3 Slc35f6 Dtnb Efr3b Fkbp1b Fam228b Gtf3c2
10 7 26984346 30734621 18 5 1.1e-12 1.5e-12 1.0e+00 100 Lta4h Vezt Tmcc3 Socs2 Metap2
11 8 95615100 97639823 3 1 1.1e-08 2.2e-07 6.7e-01 99 Atp1b3
12 9 12682987 14081256 1 1 2.6e-07 4.7e-08 3.6e-05 43 Med20
13 9 106643967 108039556 1 1 4.8e-08 1.0e-08 3.1e-01 97 Ptprm
14 10 92666462 94597282 2 1 1.4e-07 9.1e-08 1.1e-02 77 Cep112
15 12 27006 6860177 36 9 1.1e-11 1.1e-10 NaN NaN Wdr95 Camsap3 Trappc5 Stard13 N4bp2l2 Brca2 Katnal1 B3glct Zfp958
16 18 11147365 13121799 2 1 1.3e-08 3.8e-06 1.4e-01 90 Dsg2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
retroperitoneal_fat_g 19.8 158 134 227.1 -0.96 0.0e+00 Dnajc27 Adcy3 Ncoa1 Babam2 Pax6 Sptlc3 Tasp1 Rbks Esf1 Ndufaf5 AABR07053185.1 Dnajc24 Flrt3 Gpn1 Kif16b Snrpb2 Zfp513 Klhl29 Pcsk2 Stx17 Dstn Rrbp1 Trim54 Slc30a3 Alg2 Vezt Mapkbp1 Tgfbr1 Preb Kat14 Dzank1 Polr3f Plppr1 Ehd4 Rbbp9 Cavin4 Tmeff1 Msantd3 Sec23b Tex10 Dtd1 Mapre3 Dpysl5 Slc35f6 Pdzd8 Scp2d1 Rab11fip2 Kcnk3 Fam204a Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Tenm4 Kif3c Grk5 Nars2 Ptprm Gab2 Asxl2 Dtnb Alg8 Aamdc Clns1a Add3 Efr3b Aqp11 Rcn1 Pdcd4 Smndc1 Gpam Shoc2 Tectb Gucy2g Acsl5 Dsg2 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Shtn1 Dcdc5 Rsf1 Cep112 Hadha Kctd21 Drc1 Nanos1 NA Vwa2 Abhd1 Dclre1a Cad Dnmt3a Disp2 Snx17 Ppm1g Tsku Zfp133 Mgme1 Otor Pak1 AABR07035218.1 Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Acer3 Smim26 Zfp512 Vti1a Sf3b6 AABR07007032.1 Itsn2 Rab10 Fkbp1b Krtcap3 Garem2 Gckr Tcf7l2 Mpv17 Fam228b Cenpo Nrbp1 AABR07054000.1 AABR07063279.1 Ccdc186 Axin2 Casp7 Gtf3c2 Slc5a6 AABR07063281.1 Sptbn5 Ism1 NA NA NA NA NA NA NA NA NA Ubxn2a NA NA NA
body_g 11.5 165 132 223.7 -0.98 0.0e+00 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Camsap3 Pcp2 Stxbp2 Retn Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Adcy3 Cdk17 Elk3 Sptlc3 Tasp1 Lta4h Hal Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Amdhd1 Pcsk2 Snrpf Ntn4 Stx17 Dstn Rrbp1 Alg2 Vezt Pgap4 Nr2c1 Mapkbp1 Tgfbr1 Kat14 Ndufa12 Dzank1 Polr3f Ehd4 Tmcc3 Plxnc1 Rbbp9 Cavin4 Tmeff1 Msantd3 Sec23b Cradd Tex10 Dtd1 Socs2 Ivd Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Pls1 Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Atp1b3 Ptprm Gab2 NA Alg8 Aamdc Add3 Efr3b Med20 Pdcd4 Smndc1 Gpam Shoc2 Tectb Gucy2g Acsl5 Habp2 Nrap Plekhs1 Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Shtn1 Nucb2 Pik3c2a Sox6 Metap2 Ccdc38 Cep112 Ganc Plekha7 Kctd21 Nanos1 Vwa2 Dclre1a Disp2 Zfp133 Arhgef18 Pex11g Mgme1 Mcemp1 Lrrc8e Otor Pak1 AABR07035218.1 Insr Zfp950 Mxi1 Mir331 Ces2c Sfxn4 Zdhhc6 Smim26 Vti1a AABR07007032.1 Itsn2 Katnal1 Tcf7l2 Pet100 AABR07054000.1 Ccdc186 RGD1311703 Fgd6 Trpc1 Axin2 Casp7 Sptbn5 N4bp2l1 B3glct Ism1 NA NA Zfp958 NA NA NA NA NA NA NA Rps13 NA NA NA
dissection: UMAP 3 of all traits 11.0 45 28 47.5 0.98 1.6e-110 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Camsap3 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Elk3 Lta4h Hal Snrpf Ntn4 Vezt Ndufa12 Tmcc3 Plxnc1 Socs2 Metap2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Mir331 Katnal1 Pet100 Fgd6 N4bp2l1 B3glct Zfp958 NA NA
kidney_right_g 8.7 85 50 84.7 -0.95 7.3e-166 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Camsap3 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Zfp189 Plppr1 Ivd Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Ptprm Gpam Gucy2g Acsl5 Habp2 Nrap Plekhs1 Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 Nucb2 Pik3c2a Sox6 Plekha7 Nanos1 Vwa2 Dclre1a Arhgef18 Pex11g Mcemp1 Lrrc8e AABR07035218.1 Insr Zfp950 Ces2c Sfxn4 Zdhhc6 Vti1a AABR07007032.1 Katnal1 Tcf7l2 Pet100 Ccdc186 RGD1311703 Casp7 Acnat1 N4bp2l1 B3glct NA NA NA Zfp958 NA NA NA NA NA NA NA Rps13 NA NA
dissection: PC 3 of all traits 8.3 19 2 3.4 -0.87 4.9e-22 Dnajc27 Adcy3 Ncoa1 Vezt Plxnc1 Socs2 Rab11fip2 Prlhr Cacul1 Asxl2 Dtnb Efr3b Dnmt3a Sfxn4 Itsn2 Cenpo NA NA NA
dissection: PC 2 of all traits 10.0 25 10 16.9 0.91 1.3e-27 Zfp958l1 Snapc2 N4bp2l2 Ncoa1 Kif16b Snrpb2 Pcsk2 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Dtnb Efr3b Med20 Nanos1 Otor Zfp950 Ces2c Sfxn4 Itsn2 Cenpo NA NA
heart_g 12.9 2 0 0.0 0.00 1.0e+00 Cacul1 Sfxn4
os_mean 13.0 1 0 0.0 0.00 1.0e+00 AABR07063279.1
EDL weight in grams 5.0 52 10 16.9 0.26 1.4e-05 Fry Rxfp2 Mcoln1 Camsap3 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Babam2 Rbks Gpn1 Zfp513 Trim54 Slc30a3 Preb Mapre3 Dpysl5 Slc35f6 Drc1 NA Abhd1 Cad Snx17 Ppm1g Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Zfp512 Krtcap3 Gckr Mpv17 Pet100 Nrbp1 AABR07063279.1 Gtf3c2 Slc5a6 AABR07063281.1 N4bp2l1 Zfp958 NA NA
Tibia length in mm 8.4 41 16 27.1 -0.99 1.3e-126 Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 Stard13 Pds5b N4bp2l2 Brca2 Cdk17 Elk3 Tasp1 Lta4h Hal Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Plxnc1 Cradd Socs2 Metap2 Ccdc38 Pex11g Lrrc8e Otor Insr Mir331 Pet100 AABR07054000.1 Fgd6 N4bp2l1 Ism1
sol weight in grams 6.6 14 0 0.0 -0.99 1.7e-33 Gpam Gucy2g Acsl5 Habp2 Afap1l2 Fhip2a Trub1 Atrnl1 Eno4 Zdhhc6 AABR07007032.1 Ccdc186 NA NA
TA weight in grams 8.1 27 21 35.6 -1.00 5.0e-105 Fry Rxfp2 Mcoln1 Camsap3 Pcp2 Stxbp2 Retn Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 Zfp958 NA
Total sessions with >9 infusions 19.8 1 0 0.0 0.00 1.0e+00 Casp7
Total cortical area 13.0 4 3 5.1 -0.99 3.8e-08 Tasp1 Esf1 Ndufaf5 AABR07054000.1
tb_th_sd 15.1 6 0 0.0 -1.00 9.8e-10 Prlhr Cacul1 Grk5 Nanos1 Ces2c Sfxn4
tautz: manual_spc20 12.6 1 0 0.0 0.00 1.0e+00 AABR07053185.1
punishment 15.9 11 0 0.0 1.00 3.1e-145 Hadhb Kif3c Asxl2 Dtnb Efr3b Hadha Drc1 Dnmt3a Rab10 Garem2 NA
Liver iron concentration 14.6 6 0 0.0 -1.00 4.0e-07 Rxfp2 Hsph1 Wdr95 AABR07035218.1 B3glct NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 35 1.65 3.9
Adipose alternative TSS 6 0.37 3.4
Adipose gene expression 55 0.66 3.5
Adipose isoform ratio 31 1.10 3.6
Adipose intron excision ratio 22 0.75 3.3
Adipose mRNA stability 29 0.84 3.5
BLA alternative polyA 4 0.33 3.5
BLA alternative TSS 9 1.07 3.6
BLA gene expression 57 0.94 3.7
BLA isoform ratio 14 0.80 3.4
BLA intron excision ratio 34 1.14 3.8
BLA mRNA stability 20 0.99 3.7
Brain alternative polyA 10 0.50 3.4
Brain alternative TSS 16 0.93 3.7
Brain gene expression 86 0.95 3.6
Brain isoform ratio 17 0.54 3.5
Brain intron excision ratio 35 0.65 3.7
Brain mRNA stability 40 0.92 3.6
Eye alternative polyA 1 0.56 3.3
Eye alternative TSS 4 1.67 3.7
Eye gene expression 14 1.25 3.8
Eye isoform ratio 3 0.85 3.5
Eye intron excision ratio 7 1.14 4.0
Eye mRNA stability 2 0.86 3.9
IL alternative polyA 2 0.33 3.2
IL alternative TSS 0 0.00 3.4
IL gene expression 28 0.77 3.7
IL isoform ratio 7 0.89 3.7
IL intron excision ratio 12 1.24 3.8
IL mRNA stability 17 1.53 3.7
LHb alternative polyA 2 0.35 3.4
LHb alternative TSS 0 0.00 3.2
LHb gene expression 31 0.97 3.8
LHb isoform ratio 9 1.20 3.8
LHb intron excision ratio 14 1.36 4.0
LHb mRNA stability 17 1.64 3.9
Liver alternative polyA 10 0.67 3.5
Liver alternative TSS 12 0.79 3.5
Liver gene expression 56 0.78 3.5
Liver isoform ratio 27 1.13 3.8
Liver intron excision ratio 49 1.12 3.4
Liver mRNA stability 28 1.14 3.7
NAcc alternative polyA 3 0.58 4.1
NAcc alternative TSS 3 0.87 3.9
NAcc gene expression 37 1.13 3.8
NAcc isoform ratio 7 0.94 3.3
NAcc intron excision ratio 9 0.94 3.8
NAcc mRNA stability 15 1.39 3.9
NAcc2 alternative polyA 9 0.81 3.4
NAcc2 alternative TSS 4 0.55 4.0
NAcc2 gene expression 54 1.01 3.7
NAcc2 isoform ratio 9 0.58 3.6
NAcc2 intron excision ratio 28 1.06 3.7
NAcc2 mRNA stability 20 1.12 3.7
OFC alternative polyA 9 1.54 4.0
OFC alternative TSS 2 0.63 4.0
OFC gene expression 36 0.97 3.8
OFC isoform ratio 4 0.49 3.5
OFC intron excision ratio 9 0.90 3.9
OFC mRNA stability 19 1.76 4.1
PL alternative polyA 2 0.33 3.5
PL alternative TSS 0 0.00 3.9
PL gene expression 33 0.89 3.6
PL isoform ratio 5 0.57 3.5
PL intron excision ratio 12 1.15 4.1
PL mRNA stability 19 1.65 3.9
PL2 alternative polyA 5 0.40 3.4
PL2 alternative TSS 6 0.64 4.0
PL2 gene expression 53 0.83 3.7
PL2 isoform ratio 17 0.92 3.6
PL2 intron excision ratio 26 0.83 3.8
PL2 mRNA stability 26 1.07 3.7

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.