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Time to tail flick, test, before self-admin

Time in sec to remove tail from noxious stimuli under test conditions in the first tail flick before self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	5.95e-14	8.29e-02	6.13e-22	Syt5
2	1	72728663	74100561	1	1	1.34e-07	3.48e-02	2.82e-05	Zfp329

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	2.58	1	0	0	0	1e+00	Syt5
Epididymis fat weight	2.21	1	0	0	0	1e+00	Syt5
Glucose	12.08	1	0	0	0	1e+00	Syt5
Right kidney weight	2.57	1	0	0	0	1e+00	Syt5
Tail length	1.75	1	0	0	0	1e+00	Zfp329
Length without tail	3.25	1	0	0	0	1e+00	Syt5
Liver weight, left	7.95	2	0	0	0	1e+00	Syt5 Zfp329
Liver weight, right	11.2	1	0	0	0	1e+00	Syt5
Tibialis anterior weight	2.35	1	0	0	0	1e+00	Syt5
Tibia length	7.53	1	0	0	0	1e+00	Syt5
Std. dev. time between licks in bursts	22.72	1	1	50	0	1e+00	Syt5
Indifference point 0 sec	6.32	1	0	0	0	1e+00	Syt5
Indifference point function ln k	8.79	1	0	0	0	1e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1e+00	Syt5
Delay discounting time to switch 0 sec	33.99	2	1	50	0	1e+00	Syt5 Zfp329
Delay discounting water rate 0 sec	6.76	2	0	0	0	1e+00	Syt5 Zfp329
Delay discounting water rate 12 sec	15.04	2	1	50	0	1e+00	Syt5 Zfp329
Delay discounting water rate 18 sec	19.1	1	0	0	0	1e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1e+00	Syt5
Light reinforcement 1	21.59	1	1	50	0	1e+00	Syt5
Light reinforcement 2	21.57	1	1	50	0	1e+00	Syt5
Reaction time num false alarms AUC	10.57	1	0	0	0	1e+00	Syt5
Reaction time mean	5.39	2	0	0	0	1e+00	Syt5 Zfp329
Reaction time mean AUC	6.15	2	0	0	0	1e+00	Syt5 Zfp329
Median of all reaction times	5.68	2	0	0	0	1e+00	Syt5 Zfp329
Reaction time omissions	5.26	1	0	0	0	1e+00	Syt5
Reaction time false alarm rate	4.67	1	0	0	0	1e+00	Syt5
Social response proportion	7.98	1	0	0	0	1e+00	Syt5
Social time	11.72	2	0	0	0	1e+00	Syt5 Zfp329
Conditioned locomotion	5.89	1	0	0	0	1e+00	Syt5
Cocaine response after cond. corrected	11.73	2	0	0	0	1e+00	Syt5 Zfp329
Cocaine response after cond. not corrected	16.42	1	0	0	0	1e+00	Syt5
Saline control response	13.17	1	0	0	0	1e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1e+00	Syt5
Pavlov. Cond. lever latency	4.88	1	0	0	0	1e+00	Zfp329
Pavlov. Cond. change in total contacts	5.08	2	0	0	0	1e+00	Syt5 Zfp329
Conditioned reinforcement - actives	14.32	2	0	0	0	1e+00	Syt5 Zfp329
Conditioned locomotion	10.4	2	0	0	0	1e+00	Syt5 Zfp329
Intermittent access intake day 1-15 change	7.2	1	0	0	0	1e+00	Syt5
Intermittent access intake escalation 2	5.26	1	0	0	0	1e+00	Syt5
Intermitt. access day 1 inactive lever presses	15.9	2	0	0	0	1e+00	Syt5 Zfp329
Intermitt. access day 15 inactive lever presses	25.13	2	1	50	0	1e+00	Syt5 Zfp329
Intermitt. access escalation Index	17.22	1	0	0	0	1e+00	Syt5
Intermittent access standard deviation	9.81	2	0	0	0	1e+00	Syt5 Zfp329
Post-drug Anxiety	10.17	1	0	0	0	1e+00	Syt5
Baseline Anxiety	18.51	2	1	50	0	1e+00	Syt5 Zfp329
Incentive Sensitization - Responses	6.78	1	0	0	0	1e+00	Syt5
Incentive Sensitization - Breakpoint	7.46	2	0	0	0	1e+00	Syt5 Zfp329
Short access day 1 total inactive lever presses	14.96	2	1	50	0	1e+00	Syt5 Zfp329
Short access day 10 total inactive lever presses	4.77	2	0	0	0	1e+00	Syt5 Zfp329
Short access day 10 total locomotion	11.18	1	0	0	0	1e+00	Syt5
Short access total locomotion	13.05	1	0	0	0	1e+00	Syt5
One hour access (0.3 mA shock)	4.75	1	0	0	0	1e+00	Zfp329
One hour access (shock baseline)	17	2	1	50	0	1e+00	Syt5 Zfp329
Number of responses in last shaping day	7.75	2	0	0	0	1e+00	Syt5 Zfp329
Context. condit. distance diff. score	4.29	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 1	61.51	1	1	50	0	1e+00	Syt5
Locomotion distance, session 1	22.42	1	1	50	0	1e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1e+00	Syt5
Locomotion distance, session 2	5.4	1	0	0	0	1e+00	Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 7	5.99	1	0	0	0	1e+00	Syt5
Locomotion distance, session 7	10.24	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 8	15.73	1	0	0	0	1e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1e+00	Syt5
Time in familiar zone, hab. session 1	10	2	0	0	0	1e+00	Syt5 Zfp329
Time in novel zone, hab. session 1	7.6	1	0	0	0	1e+00	Zfp329
Total zone transitions, hab. session 1	25.53	1	1	50	0	1e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	50	0	1e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1e+00	Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1e+00	Syt5
Total locomotion distance, hab. session 2	10.72	1	0	0	0	1e+00	Syt5
Locomotion velocity, hab. session 2	8.77	2	0	0	0	1e+00	Syt5 Zfp329
Total zone transitions, NPP test	4.12	1	0	0	0	1e+00	Syt5
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1e+00	Syt5
Pavlov. Cond. lever contacts	4.84	1	0	0	0	1e+00	Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	0	1e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	0	1e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	0	1e+00	Syt5
Bone: cortical thickness	3.19	1	0	0	0	1e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	0	1e+00	Syt5
Bone: elastic work	5.06	2	0	0	0	1e+00	Syt5 Zfp329
Bone: post-yield work	11.59	1	0	0	0	1e+00	Syt5
Bone: stiffness	4.47	1	0	0	0	1e+00	Syt5
Bone: tissue strength	11.78	2	0	0	0	1e+00	Syt5 Zfp329
Bone: trabecular tissue density	7.11	2	0	0	0	1e+00	Syt5 Zfp329
Distance traveled before self-admin	32.35	2	1	50	0	1e+00	Syt5 Zfp329
Distance traveled after self-admin	35.23	2	1	50	0	1e+00	Syt5 Zfp329
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1e+00	Syt5
Diff in mean of infusions in LGA sessions	13.78	2	0	0	0	1e+00	Syt5 Zfp329
Extinction: sum of active levers before priming	21.69	2	1	50	0	1e+00	Syt5 Zfp329
Active lever presses in extinction session 6	13.03	2	0	0	0	1e+00	Syt5 Zfp329
Time in closed arm after self-admin	22.26	1	0	0	0	1e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1e+00	Syt5
Time to tail flick, test, after self-admin	5.74	1	0	0	0	1e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1e+00	Syt5
Delta time to tail flick, test, before/after SA	29.61	2	1	50	0	1e+00	Syt5 Zfp329
Ambulatory time before self-admin	36.65	1	1	50	0	1e+00	Syt5
Ambulatory time after self-admin	37.13	2	1	50	0	1e+00	Syt5 Zfp329
Total heroin consumption	5.77	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 0s delay	21.16	2	1	50	0	1e+00	Syt5 Zfp329
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1e+00	Syt5
Change in fecal boli incidents, locomotor task	6.15	1	0	0	0	1e+00	Syt5
Bouts of movement, locomotor time 1	32.99	2	1	50	0	1e+00	Syt5 Zfp329
Total resting periods, locomotor time 1	37.3	1	1	50	0	1e+00	Syt5
Vertical activity count, locomotor time 1	14.71	2	0	0	0	1e+00	Syt5 Zfp329
Rest time, locomotor task time 2	6.78	2	0	0	0	1e+00	Syt5 Zfp329
Vertical activity count, locomotor time 2	5.62	1	0	0	0	1e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	19.5	2	1	50	0	1e+00	Syt5 Zfp329
Locomotion in novel chamber	12.66	1	0	0	0	1e+00	Syt5
Progressive ratio	6.09	2	0	0	0	1e+00	Syt5 Zfp329
Food seeking constrained by brief footshock	94.95	2	2	100	0	1e+00	Syt5 Zfp329
Seeking ratio, punishment vs. effort	11.54	2	0	0	0	1e+00	Syt5 Zfp329
Run reversals in cocaine runway, females	8.33	1	0	0	0	1e+00	Syt5
Cd content in liver	6.16	2	0	0	0	1e+00	Syt5 Zfp329
Co content in liver	19.37	1	0	0	0	1e+00	Syt5
Rb content in liver	6.49	1	0	0	0	1e+00	Syt5
Sr content in liver	38.45	2	1	50	0	1e+00	Syt5 Zfp329
Zn content in liver	12.43	1	0	0	0	1e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.04
Adipose	alternative TSS	0	0	1.03
Adipose	gene expression	0	0	1
Adipose	isoform ratio	0	0	0.97
Adipose	intron excision ratio	0	0	0.95
Adipose	mRNA stability	0	0	1.03
BLA	alternative polyA	0	0	1.01
BLA	alternative TSS	0	0	1.17
BLA	gene expression	0	0	1
BLA	isoform ratio	0	0	0.98
BLA	intron excision ratio	0	0	0.95
BLA	mRNA stability	1	0	0.98
Brain	alternative polyA	0	0	0.95
Brain	alternative TSS	0	0	1.02
Brain	gene expression	0	0	1.01
Brain	isoform ratio	1	0	0.99
Brain	intron excision ratio	0	0	0.94
Brain	mRNA stability	0	0	1
Eye	alternative polyA	0	0	1
Eye	alternative TSS	0	0	1.25
Eye	gene expression	0	0	0.98
Eye	isoform ratio	0	0	1.09
Eye	intron excision ratio	0	0	0.81
Eye	mRNA stability	0	0	0.88
IL	alternative polyA	0	0	0.86
IL	alternative TSS	0	0	1.02
IL	gene expression	0	0	0.98
IL	isoform ratio	0	0	0.96
IL	intron excision ratio	0	0	1
IL	mRNA stability	0	0	0.99
LHb	alternative polyA	0	0	0.95
LHb	alternative TSS	0	0	1.12
LHb	gene expression	0	0	0.99
LHb	isoform ratio	0	0	1
LHb	intron excision ratio	0	0	0.94
LHb	mRNA stability	0	0	1.02
Liver	alternative polyA	0	0	0.92
Liver	alternative TSS	0	0	1.07
Liver	gene expression	0	0	1.02
Liver	isoform ratio	0	0	0.96
Liver	intron excision ratio	0	0	0.95
Liver	mRNA stability	0	0	0.99
NAcc	alternative polyA	0	0	0.97
NAcc	alternative TSS	0	0	1.12
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	0.96
NAcc	intron excision ratio	0	0	0.97
NAcc	mRNA stability	0	0	0.94
OFC	alternative polyA	0	0	0.94
OFC	alternative TSS	0	0	0.96
OFC	gene expression	0	0	0.99
OFC	isoform ratio	0	0	0.99
OFC	intron excision ratio	0	0	1
OFC	mRNA stability	0	0	0.97
PL	alternative polyA	0	0	0.95
PL	alternative TSS	0	0	0.98
PL	gene expression	0	0	1.01
PL	isoform ratio	0	0	0.97
PL	intron excision ratio	0	0	0.94
PL	mRNA stability	0	0	0.98