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Time to tail flick, vehicle, after self-admin

Time in sec to remove tail from noxious stimuli under vehicle conditions in the second tail flick after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	8	108584253	109845634	1	1	2.22e-07	2.07e-01	5.32e-02	Ccdc71

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.89	1	0	0	0	1e+00	Ccdc71
Body weight	1.78	1	0	0	0	1e+00	Ccdc71
Heart weight	11.59	1	0	0	0	1e+00	Ccdc71
Liver weight, left	5.07	1	0	0	0	1e+00	Ccdc71
Indifference point AUC	6.21	1	0	0	0	1e+00	Ccdc71
Indifference point function ln k	5.32	1	0	0	0	1e+00	Ccdc71
Indifference point function log k	5.32	1	0	0	0	1e+00	Ccdc71
Delay discounting total patch changes 18 sec	4.48	1	0	0	0	1e+00	Ccdc71
Delay discounting total patch changes 6 sec	4.1	1	0	0	0	1e+00	Ccdc71
Locomotor activity	9.02	1	0	0	0	1e+00	Ccdc71
Locomotor testing distance	7.99	1	0	0	0	1e+00	Ccdc71
Light reinforcement 2	2.93	1	0	0	0	1e+00	Ccdc71
Reaction time num false alarms	5.82	1	0	0	0	1e+00	Ccdc71
Reaction time num false alarms AUC	5.56	1	0	0	0	1e+00	Ccdc71
Reaction time false alarm rate	7.4	1	0	0	0	1e+00	Ccdc71
Short access day 10 total inactive lever presses	5.56	1	0	0	0	1e+00	Ccdc71
Short access day 1 locomotion	9.38	1	0	0	0	1e+00	Ccdc71
Short access total locomotion	4.43	1	0	0	0	1e+00	Ccdc71
One hour access (0.3 mA shock)	4.57	1	0	0	0	1e+00	Ccdc71
Locomotion velocity, session 2	4.57	1	0	0	0	1e+00	Ccdc71
Locomotion distance, session 2	3.07	1	0	0	0	1e+00	Ccdc71
Condit. Reinf. active minus inactive responses	3.92	1	0	0	0	1e+00	Ccdc71
Total zone transitions, hab. session 2	4.65	1	0	0	0	1e+00	Ccdc71
Total zone transitions, NPP test	5.31	1	0	0	0	1e+00	Ccdc71
Pavlov. Cond. change in total contacts	6.21	1	0	0	0	1e+00	Ccdc71
Delta time in closed arm before/after self-admin	7.64	1	0	0	0	1e+00	Ccdc71
Active lever presses in extinction session 6	9.22	1	0	0	0	1e+00	Ccdc71
Time in open arm after self-admin	4.19	1	0	0	0	1e+00	Ccdc71
Time to tail flick, test, before self-admin	5.19	1	0	0	0	1e+00	Ccdc71
Delta time to tail flick, vehicle, before/after SA	14.69	1	0	0	0	1e+00	Ccdc71
Total heroin consumption	11.67	1	0	0	0	1e+00	Ccdc71
Delay disc. indifference point, 0s delay	11.74	1	0	0	0	1e+00	Ccdc71
Delay disc. indifference point, 4s delay	8.24	1	0	0	0	1e+00	Ccdc71
Fecal boli incidents, locomotor time 1	3.73	1	0	0	0	1e+00	Ccdc71
Rest time, locomotor task time 1	4.02	1	0	0	0	1e+00	Ccdc71
Distance moved, locomotor task time 1	8.37	1	0	0	0	1e+00	Ccdc71
Vertical activity count, locomotor time 1	13.16	1	0	0	0	1e+00	Ccdc71
Rest time, locomotor task time 2	5.41	1	0	0	0	1e+00	Ccdc71
Distance moved, locomotor task time 2	12.09	1	0	0	0	1e+00	Ccdc71
Vertical activity count, locomotor time 2	13.6	1	0	0	0	1e+00	Ccdc71
Weight adjusted by age	9.59	1	0	0	0	1e+00	Ccdc71
Run reversals in cocaine runway, females	10.39	1	0	0	0	1e+00	Ccdc71
Run reversals in cocaine runway, males	7.93	1	0	0	0	1e+00	Ccdc71
Latency to leave start box in cocaine runway, M	11.17	1	0	0	0	1e+00	Ccdc71
Fe content in liver	3.79	1	0	0	0	1e+00	Ccdc71
Rb content in liver	5.17	1	0	0	0	1e+00	Ccdc71

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.06
Adipose	alternative TSS	0	0	1.05
Adipose	gene expression	0	0	1.08
Adipose	isoform ratio	0	0	1.06
Adipose	intron excision ratio	0	0	1.02
Adipose	mRNA stability	0	0	1.09
BLA	alternative polyA	0	0	1.11
BLA	alternative TSS	0	0	1.05
BLA	gene expression	0	0	1.12
BLA	isoform ratio	0	0	1.09
BLA	intron excision ratio	0	0	1.09
BLA	mRNA stability	0	0	1.06
Brain	alternative polyA	0	0	1.11
Brain	alternative TSS	0	0	1.03
Brain	gene expression	0	0	1.08
Brain	isoform ratio	0	0	1.07
Brain	intron excision ratio	0	0	1.05
Brain	mRNA stability	0	0	1.06
Eye	alternative polyA	0	0	0.94
Eye	alternative TSS	0	0	1.29
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	1.15
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	0.95
IL	alternative polyA	0	0	0.98
IL	alternative TSS	0	0	0.98
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	0.99
IL	intron excision ratio	0	0	1.04
IL	mRNA stability	0	0	1.09
LHb	alternative polyA	0	0	1.07
LHb	alternative TSS	0	0	1.02
LHb	gene expression	0	0	1.1
LHb	isoform ratio	1	0.1	1.13
LHb	intron excision ratio	0	0	1.02
LHb	mRNA stability	0	0	1.05
Liver	alternative polyA	0	0	1.08
Liver	alternative TSS	0	0	1.12
Liver	gene expression	0	0	1.08
Liver	isoform ratio	0	0	1.09
Liver	intron excision ratio	0	0	1
Liver	mRNA stability	0	0	1.1
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1
NAcc	gene expression	0	0	1.08
NAcc	isoform ratio	0	0	1.11
NAcc	intron excision ratio	0	0	1.05
NAcc	mRNA stability	0	0	1.11
OFC	alternative polyA	0	0	1.1
OFC	alternative TSS	0	0	1.15
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.04
OFC	intron excision ratio	0	0	1.03
OFC	mRNA stability	0	0	1.04
PL	alternative polyA	0	0	1.05
PL	alternative TSS	0	0	1.07
PL	gene expression	0	0	1.09
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1.05
PL	mRNA stability	0	0	1.1