Hub : Traits

Time to tail flick, vehicle, before self-admin

Time in sec to remove tail from noxious stimuli under vehicle conditions in the first tail flick before self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	198316555	199708396	1	1	3.2e-08	2.31e-03	5.55e-02	Dhcr7

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Parametrial fat weight	3.73	1	0	0	0	1e+00	Dhcr7
Retroperitoneal fat weight	2.37	1	0	0	0	1e+00	Dhcr7
Tibialis anterior weight	4.48	1	0	0	0	1e+00	Dhcr7
Times rat made contact with spout	4.05	1	0	0	0	1e+00	Dhcr7
Indifference point function ln k	4.16	1	0	0	0	1e+00	Dhcr7
Indifference point function log k	4.16	1	0	0	0	1e+00	Dhcr7
Delay discounting total patch changes 6 sec	2.94	1	0	0	0	1e+00	Dhcr7
Delay discounting water rate 0 sec	2.91	1	0	0	0	1e+00	Dhcr7
Delay discounting water rate 12 sec	3.86	1	0	0	0	1e+00	Dhcr7
Delay discounting water rate 18 sec	3.53	1	0	0	0	1e+00	Dhcr7
Delay discounting water rate 24 sec	3.74	1	0	0	0	1e+00	Dhcr7
Delay discounting water rate 6 sec	3.25	1	0	0	0	1e+00	Dhcr7
Reaction time mean minus median	4.78	1	0	0	0	1e+00	Dhcr7
Reaction time mean minus median AUC	7.33	1	0	0	0	1e+00	Dhcr7
Reaction time false alarm rate	2.77	1	0	0	0	1e+00	Dhcr7
Std. dev. reaction times	3.22	1	0	0	0	1e+00	Dhcr7
Social responses	3.33	1	0	0	0	1e+00	Dhcr7
Condit. Reinf. active minus inactive responses	3.69	1	0	0	0	1e+00	Dhcr7
Condit. Reinf. active-inactive response ratio	3.97	1	0	0	0	1e+00	Dhcr7
Conditioned locomotion	5.98	1	0	0	0	1e+00	Dhcr7
Intermittent access intake day 1-15 change	10.34	1	0	0	0	1e+00	Dhcr7
Intermittent access intake escalation	14.59	1	0	0	0	1e+00	Dhcr7
Intermittent access intake escalation 2	7.47	1	0	0	0	1e+00	Dhcr7
Intermittent access day 15 total infusions	13.56	1	0	0	0	1e+00	Dhcr7
Intermittent access terminal intake (last 3 days)	7.54	1	0	0	0	1e+00	Dhcr7
Intermittent access day 15 total locomotion	20.29	1	0	0	0	1e+00	Dhcr7
Intermittent access total locomotion	8.11	1	0	0	0	1e+00	Dhcr7
Intermittent access standard deviation	4.23	1	0	0	0	1e+00	Dhcr7
Cocaine induced anxiety	5.95	1	0	0	0	1e+00	Dhcr7
Post-drug Anxiety	3.54	1	0	0	0	1e+00	Dhcr7
Baseline Anxiety	5.19	1	0	0	0	1e+00	Dhcr7
Lifetime Intake	3.67	1	0	0	0	1e+00	Dhcr7
Progressive ratio test 2 inactive lever presses	4.73	1	0	0	0	1e+00	Dhcr7
Short access day 10 total infusions	4.9	1	0	0	0	1e+00	Dhcr7
One hour access (0.3 mA shock)	15.05	1	0	0	0	1e+00	Dhcr7
One hour access (shock baseline)	4.5	1	0	0	0	1e+00	Dhcr7
Locomotion distance, session 2	3.8	1	0	0	0	1e+00	Dhcr7
Condit. Reinf. lever presses	3.03	1	0	0	0	1e+00	Dhcr7
Total zone transitions, hab. session 2	4.22	1	0	0	0	1e+00	Dhcr7
Total zone transitions, NPP test	2.86	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. lever latency	3.15	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. index score	5.02	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. latency score	3.93	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. lever contacts	3.95	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. magazine entry number	4.9	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. lever-magazine prob. diff.	4.17	1	0	0	0	1e+00	Dhcr7
Pavlov. Cond. response bias	6.04	1	0	0	0	1e+00	Dhcr7
Bone: post-yield work	5.83	1	0	0	0	1e+00	Dhcr7
Bone: tissue strength	5.2	1	0	0	0	1e+00	Dhcr7
Delta time in open arm before/after self-admin	9.15	1	0	0	0	1e+00	Dhcr7
Active lever presses in extinction session 6	6.86	1	0	0	0	1e+00	Dhcr7
Time in open arm before self-admin	5.58	1	0	0	0	1e+00	Dhcr7
Delta time to tail flick, vehicle, before/after SA	4.03	1	0	0	0	1e+00	Dhcr7
Delay disc. indifference point, 4s delay	3.68	1	0	0	0	1e+00	Dhcr7
Rest time, locomotor task time 1	3.97	1	0	0	0	1e+00	Dhcr7
Run reversals in cocaine runway, males	17.48	1	0	0	0	1e+00	Dhcr7
Mn content in liver	4.7	1	0	0	0	1e+00	Dhcr7

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.08
Adipose	alternative TSS	0	0	1.11
Adipose	gene expression	0	0	0.99
Adipose	isoform ratio	0	0	1
Adipose	intron excision ratio	0	0	1.03
Adipose	mRNA stability	0	0	0.99
BLA	alternative polyA	0	0	1.16
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	1.01
BLA	isoform ratio	0	0	0.98
BLA	intron excision ratio	0	0	1.01
BLA	mRNA stability	0	0	1.01
Brain	alternative polyA	0	0	1.12
Brain	alternative TSS	0	0	1.03
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.02
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	1
Eye	alternative polyA	0	0	0.78
Eye	alternative TSS	0	0	0.92
Eye	gene expression	0	0	0.97
Eye	isoform ratio	0	0	1.01
Eye	intron excision ratio	0	0	1.01
Eye	mRNA stability	0	0	0.87
IL	alternative polyA	0	0	1.06
IL	alternative TSS	0	0	1.05
IL	gene expression	0	0	0.97
IL	isoform ratio	0	0	0.98
IL	intron excision ratio	0	0	0.93
IL	mRNA stability	0	0	0.98
LHb	alternative polyA	0	0	1.15
LHb	alternative TSS	0	0	0.76
LHb	gene expression	0	0	1.03
LHb	isoform ratio	0	0	0.97
LHb	intron excision ratio	0	0	1.04
LHb	mRNA stability	0	0	0.99
Liver	alternative polyA	0	0	1.06
Liver	alternative TSS	0	0	1.03
Liver	gene expression	1	0	1.02
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	0.99
Liver	mRNA stability	0	0	1.03
NAcc	alternative polyA	0	0	1.11
NAcc	alternative TSS	0	0	1.02
NAcc	gene expression	0	0	1.03
NAcc	isoform ratio	0	0	1.02
NAcc	intron excision ratio	0	0	1.04
NAcc	mRNA stability	0	0	1
OFC	alternative polyA	0	0	1.04
OFC	alternative TSS	0	0	1
OFC	gene expression	0	0	1
OFC	isoform ratio	0	0	0.96
OFC	intron excision ratio	0	0	0.96
OFC	mRNA stability	0	0	1
PL	alternative polyA	0	0	1.09
PL	alternative TSS	0	0	1.06
PL	gene expression	0	0	1
PL	isoform ratio	0	0	0.98
PL	intron excision ratio	0	0	0.97
PL	mRNA stability	0	0	1.03