Hub : Traits

Bone: stiffness

Tags: Physiology · Bone

Project: r01_doug_adams

2 loci · 11 genes with independent associations · 66 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	7	16845355	16970279	1	1	5.93e-49	NaN	NA	ENSRNOG00000064438
2	7	128200675	132492191	65	10	1.25e-08	2.97e-08	1e+00	Slc48a1 Tmem106c Tuba1b Fkbp11 Hdac7 Dip2b Bcdin3d Asic1 Prkag1 Fkbp11

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	5.11	47	0	0	1	4.38e-207	Mettl7a Asb8 Slc11a2 Tuba1c Senp1 Letmd1 Zfp641 Olr1106 Galnt6 Faim2 Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Cacnb3 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Nckap5l Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000065389 ENSRNOG00000067620 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
BMI without tail	106.71	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Body weight	5.88	66	35	318.2	0.99	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Epididymis fat weight	87.61	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Heart weight	11.41	1	0	0	0	1.00e+00	ENSRNOG00000064438
Left kidney weight	37.46	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Right kidney weight	41.88	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Tail length	58.13	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Length without tail	8.18	42	1	9.1	0.9	7.31e-94	Asb8 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d ENSRNOG00000061607 ENSRNOG00000063058 ENSRNOG00000064438 ENSRNOG00000067620 ENSRNOG00000069732 Prkag1 Olr1877 Olr1108 Fkbp11
Liver weight, left	23.57	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Liver weight, right	9.6	1	0	0	0	1.00e+00	ENSRNOG00000064438
Parametrial fat weight	26.35	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intraocular pressure	14.38	4	1	9.1	-0.96	2.83e-03	Tmem106c Hdac7 Pfkm ENSRNOG00000064438
Extensor digitorum longus weight	4.75	64	4	36.4	0.93	5.81e-150	Mettl7a Asb8 Slc11a2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Soleus weight	13.71	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Tibialis anterior weight	8.8	6	1	9.1	0.15	4.56e-01	Mettl7a Slc11a2 Letmd1 Dip2b Smagp ENSRNOG00000064438
Tibia length	7.23	50	4	36.4	0.99	6.61e-263	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d ENSRNOG00000061607 ENSRNOG00000063058 ENSRNOG00000064438 ENSRNOG00000067620 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Number of licking bursts	155.04	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Food consumed during 24 hour testing period	17.5	1	0	0	0	1.00e+00	ENSRNOG00000064438
Times rat made contact with spout	75.14	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Mean time between licks in bursts	54.91	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Mean num. licks in bursts	164.17	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Std. dev. time between licks in bursts	177.72	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Indifference point 0 sec	18.72	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Indifference point AUC	42.09	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 0 sec	17.74	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 12 sec	102.69	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 18 sec	175.33	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 24 sec	28.3	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 6 sec	98.45	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting water rate 0 sec	11.76	1	0	0	0	1.00e+00	ENSRNOG00000064438
Delay discounting water rate 12 sec	44.18	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting water rate 24 sec	62.69	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting water rate 6 sec	44.17	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotor testing distance	11.51	1	0	0	0	1.00e+00	ENSRNOG00000064438
Locomotor testing rearing	16.83	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Light reinforcement 1	54.81	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time num false alarms	56.4	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time num false alarms AUC	79.45	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time mean	41.28	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time mean AUC	57.96	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Median of all reaction times	51.19	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time omissions	11.46	5	0	0	-1	2.89e-07	Slc48a1 Tuba1b Pfkm Olr1877 Fkbp11
Reaction time false alarm rate	63.39	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time premature initiation rate	32.14	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time premature initiations	34.33	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Std. dev. reaction times	26.97	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Reaction time trials AUC	15.57	1	0	0	0	1.00e+00	ENSRNOG00000064438
Social responses	74.35	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response after cond. corrected	77.95	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response after cond. not corrected	102.33	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response before conditioning	28.56	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Saline control response	50.64	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	29.4	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	68.68	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active responses	11.07	1	0	0	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	20.59	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	36.27	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	104.88	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	130.08	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. index score	62.19	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	67.08	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	29.45	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	150.01	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. intertrial magazine entries	63.93	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	55.11	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	51.3	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Conditioned reinforcement - actives	18.52	1	0	0	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake day 1-15 change	61.45	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake escalation	82.51	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake escalation 2	42.55	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intermitt. access day 1 inactive lever presses	30.61	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access day 1 total infusions	52.87	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access day 1 locomotion	27.14	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Post-drug Anxiety	20.58	1	0	0	0	1.00e+00	ENSRNOG00000064438
Progressive ratio test 2 breakpoint	38.7	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Short access day 10 total infusions	24.04	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Short access day 1 locomotion	17.24	1	0	0	0	1.00e+00	ENSRNOG00000064438
Compulsive drug intake	45.38	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Context. condit. distance diff. score	149.78	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 1	117.78	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 1	374.74	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 2	82.2	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 2	775.97	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 3	116.11	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 3	82.39	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 3	25.57	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 7	66.34	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 7	31.83	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 7	42.65	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 7	63.39	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 8	102.75	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Degree of sensitization distance	140.58	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Degree of sensitization stereotypy	37.55	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	65.09	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active responses	20.03	1	0	0	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	17.25	1	0	0	0	1.00e+00	ENSRNOG00000064438
Incentive salience index mean	15.58	1	0	0	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. lever presses	35.11	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 1	16.37	1	0	0	0	1.00e+00	ENSRNOG00000064438
Time in novel zone, hab. session 1	17.41	1	0	0	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, hab. session 1	415.63	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 1	171.39	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 1	218.59	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 2	48.88	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in novel zone, hab. session 2	58.43	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, hab. session 2	256.06	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 2	133.05	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 2	139.44	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, NPP test	228.75	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, NPP test	163.42	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, NPP test	195.87	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	56.4	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	40.12	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. index score	51.85	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	16.59	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	16.14	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	61.65	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	50.47	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	52.36	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: apparent density	10.7	44	1	9.1	0.96	4.45e-152	Asb8 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d ENSRNOG00000061607 ENSRNOG00000063058 ENSRNOG00000064438 ENSRNOG00000067620 ENSRNOG00000069732 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone surface	11.52	65	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone volume	9.65	56	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000068156 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Fkbp11
Bone: connectivity density	9.56	2	0	0	0	1.00e+00	Ccdc65 Prkag1
Bone: cortical area	10.52	33	0	0	1	1.68e-203	Asb8 Tuba1c Senp1 Zfp641 Olr1106 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Hdac7 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d ENSRNOG00000061607 ENSRNOG00000063058 ENSRNOG00000067620 ENSRNOG00000069732 Prkag1 Olr1877 Olr1108 Fkbp11
Bone: cortical porosity	109.3	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: cortical porosity	91.2	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: cortical thickness	17.92	1	0	0	0	1.00e+00	ENSRNOG00000064438
Bone: elastic displacement	28.18	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: endosteal estimation	7.88	63	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: endosteal perimeter	7.55	40	0	0	1	2.44e-118	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Zfp641 Faim2 Prph Cers5 Slc48a1 Tmem106c Tuba1b Cacnb3 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Gpd1 Nckap5l Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rapgef3 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 ENSRNOG00000065389 ENSRNOG00000067620 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1108 Fkbp11
Bone: final force	10.65	66	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: final moment	11.44	66	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: marrow area	7.76	62	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: maximum force	14.43	66	32	290.9	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: maximum moment	15.3	66	48	436.4	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: minimum diameter	9.36	64	1	9.1	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: periosteal estimation	11.2	66	22	200	0.99	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000063063 ENSRNOG00000064438 ENSRNOG00000064897 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: periosteal perimeter	10.24	60	0	0	1	0.00e+00	Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 ENSRNOG00000061607 Smagp ENSRNOG00000063058 ENSRNOG00000065389 ENSRNOG00000065833 ENSRNOG00000067620 Larp4 ENSRNOG00000068156 ENSRNOG00000069732 ENSRNOG00000069802 Prkag1 ENSRNOG00000070544 Olr1877 Olr1108 Fkbp11
Bone: post-yield work	82.77	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: tissue strength	80.98	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Bone: trabecular number	29.53	2	1	9.1	0	1.00e+00	Ccdc65 ENSRNOG00000064438
Bone: trabecular thickness	13.82	1	0	0	0	1.00e+00	ENSRNOG00000064438
Bone: trabecular tissue density	43.06	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delta time in open arm before/after self-admin	40.25	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in closed arm before self-admin	50.04	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in closed arm after self-admin	40.16	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Time in open arm after self-admin	31.26	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Delta time to tail flick, test, before/after SA	20.03	1	0	0	0	1.00e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 1	19.54	1	0	0	0	1.00e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 2	27.2	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Distance moved, locomotor task time 2	13.12	1	0	0	0	1.00e+00	ENSRNOG00000064438
Weight adjusted by age	24.99	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Run reversals in cocaine runway, males	39.32	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway	18.78	1	0	0	0	1.00e+00	ENSRNOG00000064438
Cd content in liver	140.46	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Co content in liver	83.15	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
K content in liver	62.65	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Mn content in liver	130.23	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Rb content in liver	31.44	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Se content in liver	46.95	1	1	9.1	0	1.00e+00	ENSRNOG00000064438
Zn content in liver	45.96	1	1	9.1	0	1.00e+00	ENSRNOG00000064438

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	6	0.3	1.5
Adipose	alternative TSS	3	0.2	1.54
Adipose	gene expression	25	0.3	1.57
Adipose	isoform ratio	7	0.2	1.53
Adipose	intron excision ratio	3	0.1	1.44
Adipose	mRNA stability	9	0.3	1.52
BLA	alternative polyA	8	0.7	1.57
BLA	alternative TSS	3	0.4	1.66
BLA	gene expression	22	0.4	1.68
BLA	isoform ratio	13	0.7	1.72
BLA	intron excision ratio	9	0.3	1.51
BLA	mRNA stability	8	0.4	1.61
Brain	alternative polyA	8	0.4	1.44
Brain	alternative TSS	0	0	1.76
Brain	gene expression	29	0.3	1.6
Brain	isoform ratio	7	0.2	1.57
Brain	intron excision ratio	13	0.2	1.5
Brain	mRNA stability	13	0.3	1.56
Eye	alternative polyA	4	2.2	2.41
Eye	alternative TSS	2	0.8	2.19
Eye	gene expression	5	0.4	1.64
Eye	isoform ratio	3	0.8	1.83
Eye	intron excision ratio	4	0.7	1.76
Eye	mRNA stability	3	1.3	1.93
IL	alternative polyA	5	0.8	1.62
IL	alternative TSS	0	0	1.66
IL	gene expression	13	0.4	1.68
IL	isoform ratio	3	0.4	1.58
IL	intron excision ratio	1	0.1	1.66
IL	mRNA stability	3	0.3	1.52
LHb	alternative polyA	6	1	1.62
LHb	alternative TSS	0	0	1.7
LHb	gene expression	12	0.4	1.66
LHb	isoform ratio	3	0.4	1.57
LHb	intron excision ratio	1	0.1	1.47
LHb	mRNA stability	3	0.3	1.51
Liver	alternative polyA	2	0.1	1.36
Liver	alternative TSS	3	0.2	1.67
Liver	gene expression	19	0.3	1.57
Liver	isoform ratio	6	0.3	1.57
Liver	intron excision ratio	3	0.1	1.47
Liver	mRNA stability	6	0.2	1.51
NAcc	alternative polyA	7	0.5	1.52
NAcc	alternative TSS	0	0	1.66
NAcc	gene expression	15	0.2	1.59
NAcc	isoform ratio	7	0.4	1.63
NAcc	intron excision ratio	6	0.2	1.56
NAcc	mRNA stability	10	0.4	1.64
OFC	alternative polyA	8	1.4	1.6
OFC	alternative TSS	0	0	1.4
OFC	gene expression	11	0.3	1.63
OFC	isoform ratio	4	0.5	1.7
OFC	intron excision ratio	2	0.2	1.57
OFC	mRNA stability	7	0.6	1.64
PL	alternative polyA	4	0.3	1.55
PL	alternative TSS	3	0.3	1.77
PL	gene expression	21	0.3	1.6
PL	isoform ratio	9	0.4	1.76
PL	intron excision ratio	11	0.3	1.54
PL	mRNA stability	8	0.3	1.57