Hub : Traits

One hour access (0.3 mA shock)

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	8	33171536	34259593	1	1	1.49e-07	2.03e-01	4.99e-01	Foxred1
2	11	39057816	40174684	1	1	5.50e-11	1.23e-02	1.00e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	4.4	1	0	0	0	1e+00	Foxred1
Heart weight	4.41	1	0	0	0	1e+00	Epha6
Right kidney weight	2.31	1	0	0	0	1e+00	Foxred1
Length without tail	4.09	1	0	0	0	1e+00	Foxred1
Parametrial fat weight	12.32	2	1	50	0	1e+00	Epha6 Foxred1
Intraocular pressure	5.23	1	0	0	0	1e+00	Epha6
Tibia length	2.39	1	0	0	0	1e+00	Epha6
Food consumed during 24 hour testing period	5.36	1	0	0	0	1e+00	Epha6
Times rat made contact with spout	14.73	1	0	0	0	1e+00	Epha6
Water consumed over 24 hours	15.6	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 12 sec	11.65	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 18 sec	13.14	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 6 sec	11.55	1	0	0	0	1e+00	Epha6
Delay discounting water rate 18 sec	10.67	1	0	0	0	1e+00	Epha6
Locomotor activity	6.88	1	0	0	0	1e+00	Epha6
Locomotor testing distance	7.95	1	0	0	0	1e+00	Epha6
Reaction time num false alarms AUC	5.31	1	0	0	0	1e+00	Foxred1
Reaction time premature initiation rate	8.75	1	0	0	0	1e+00	Epha6
Reaction time premature initiations	4.96	1	0	0	0	1e+00	Epha6
Conditioned locomotion	14.73	1	0	0	0	1e+00	Epha6
Cocaine response before conditioning	6.74	1	0	0	0	1e+00	Epha6
Condit. Reinf. lever presses	6.01	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	5.16	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever contacts	5.63	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	6.55	1	0	0	0	1e+00	Epha6
Pavlov. Cond. response bias	4.45	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - actives	21.15	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - inactives	20.56	2	1	50	0	1e+00	Epha6 Foxred1
Intermittent access intake day 1-15 change	21.77	1	0	0	0	1e+00	Foxred1
Intermittent access intake escalation	10.63	1	0	0	0	1e+00	Foxred1
Intermittent access intake escalation 2	14.31	1	0	0	0	1e+00	Foxred1
Intermitt. access day 1 inactive lever presses	11.34	1	0	0	0	1e+00	Foxred1
Intermittent access day 1 total infusions	10.58	1	0	0	0	1e+00	Epha6
Intermittent access day 15 total infusions	11.39	2	0	0	0	1e+00	Epha6 Foxred1
Intermittent access terminal intake (last 3 days)	15.32	2	0	0	0	1e+00	Epha6 Foxred1
Intermittent access total infusions	17.65	1	0	0	0	1e+00	Epha6
Cocaine induced anxiety	15.39	1	0	0	0	1e+00	Epha6
Post-drug Anxiety	5.89	1	0	0	0	1e+00	Epha6
Baseline Anxiety	18.76	1	0	0	0	1e+00	Epha6
Lifetime Intake	23.96	2	1	50	0	1e+00	Epha6 Foxred1
Incentive Sensitization - Responses	8.2	2	0	0	0	1e+00	Epha6 Foxred1
Incentive Sensitization - Breakpoint	7.81	2	0	0	0	1e+00	Epha6 Foxred1
Progressive ratio test 1 active lever presses	25.44	1	1	50	0	1e+00	Epha6
Progressive ratio test 1 breakpoint	30.13	1	1	50	0	1e+00	Epha6
Progressive ratio test 1 inactive lever presses	9.17	1	0	0	0	1e+00	Epha6
Progressive ratio test 2 active lever presses	31.2	1	1	50	0	1e+00	Epha6
Progressive ratio test 2 breakpoint	24.05	1	1	50	0	1e+00	Epha6
Progressive ratio test 2 inactive lever presses	22.14	2	1	50	0	1e+00	Epha6 Foxred1
Total sessions with >9 infusions	13.01	2	0	0	0	1e+00	Epha6 Foxred1
Short access day 1 total inactive lever presses	6.58	1	0	0	0	1e+00	Epha6
Short access day 1 total infusions	26.8	2	1	50	0	1e+00	Epha6 Foxred1
Short access day 10 total infusions	7.06	1	0	0	0	1e+00	Foxred1
Short access total infusions	29.42	2	1	50	0	1e+00	Epha6 Foxred1
One hour access (shock baseline)	18.63	2	0	0	0	1e+00	Epha6 Foxred1
Locomotion distance, session 1	10.11	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 3	7.02	1	0	0	0	1e+00	Epha6
Locomotion velocity, session 7	6.82	1	0	0	0	1e+00	Epha6
Locomotion distance, session 7	12.27	1	0	0	0	1e+00	Epha6
Locomotion distance, session 8	5.02	1	0	0	0	1e+00	Epha6
Degree of sensitization distance	6.07	1	0	0	0	1e+00	Epha6
Condit. Reinf. active minus inactive responses	9.43	1	0	0	0	1e+00	Epha6
Condit. Reinf. active-inactive response ratio	8.4	1	0	0	0	1e+00	Epha6
Condit. Reinf. active responses	7.45	1	0	0	0	1e+00	Epha6
Incentive salience index mean	7.92	1	0	0	0	1e+00	Epha6
Condit. Reinf. lever presses	8.2	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 1	9.26	1	0	0	0	1e+00	Epha6
Time in novel zone, hab. session 1	6.42	1	0	0	0	1e+00	Epha6
Total zone transitions, hab. session 1	8.13	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 1	6.08	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 2	29.91	1	1	50	0	1e+00	Epha6
Time in novel zone, hab. session 2	25.18	1	1	50	0	1e+00	Epha6
Total zone transitions, hab. session 2	6.11	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 2	8.19	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 2	8.08	1	0	0	0	1e+00	Epha6
Novelty place preference	5.77	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	14.56	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry latency	31.42	1	1	50	0	1e+00	Epha6
Pavlov. Cond. change in total contacts	7.31	1	0	0	0	1e+00	Epha6
Pavlov. Cond. index score	24.26	1	1	50	0	1e+00	Epha6
Pavlov. Cond. latency score	22.39	1	1	50	0	1e+00	Epha6
Pavlov. Cond. lever contacts	20.49	1	1	50	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	12.84	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	22.92	1	1	50	0	1e+00	Epha6
Pavlov. Cond. response bias	24.61	1	1	50	0	1e+00	Epha6
Bone surface	4.2	1	0	0	0	1e+00	Epha6
Bone: connectivity density	4.61	1	0	0	0	1e+00	Epha6
Bone: cortical area	4.5	1	0	0	0	1e+00	Foxred1
Bone: cortical porosity	5.58	1	0	0	0	1e+00	Epha6
Bone: cortical thickness	13.39	1	0	0	0	1e+00	Epha6
Bone: endosteal estimation	3.29	1	0	0	0	1e+00	Epha6
Bone: marrow area	2.98	1	0	0	0	1e+00	Epha6
Bone: maximum diameter	6.08	1	0	0	0	1e+00	Epha6
Bone: maximum force	5	1	0	0	0	1e+00	Foxred1
Bone: maximum moment	5.39	1	0	0	0	1e+00	Foxred1
Bone: periosteal estimation	2.98	1	0	0	0	1e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	0	1e+00	Epha6
Bone: stiffness	6.97	1	0	0	0	1e+00	Epha6
Time to tail flick, vehicle, after self-admin	5.91	1	0	0	0	1e+00	Foxred1
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	7.69	2	0	0	0	1e+00	Epha6 Foxred1
Total heroin consumption	5.1	1	0	0	0	1e+00	Epha6
Area under the delay curve	6.54	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 0s delay	11.03	2	0	0	0	1e+00	Epha6 Foxred1
Delay disc. indifference point, 4s delay	9.74	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 8s delay	7.89	1	0	0	0	1e+00	Epha6
Delay discount exponential model param	6.64	1	0	0	0	1e+00	Epha6
Delay discount hyperbolic model param	6.66	1	0	0	0	1e+00	Epha6
Time >=10cm from walls, locomotor time 1	6.04	1	0	0	0	1e+00	Epha6
Bouts of movement, locomotor time 1	7.86	1	0	0	0	1e+00	Epha6
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1e+00	Epha6
Rest time, locomotor task time 2	5.68	1	0	0	0	1e+00	Epha6
Seeking ratio, delayed vs. immediate footshock	11.05	1	0	0	0	1e+00	Epha6
Locomotion in novel chamber post-restriction	15.32	1	0	0	0	1e+00	Epha6
Latency to leave start box in cocaine runway	8.54	1	0	0	0	1e+00	Epha6
Co content in liver	10.41	1	0	0	0	1e+00	Foxred1
Na content in liver	10.19	1	0	0	0	1e+00	Epha6
Se content in liver	11.12	1	0	0	0	1e+00	Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.23
Adipose	alternative TSS	0	0	1.17
Adipose	gene expression	0	0	1.16
Adipose	isoform ratio	0	0	1.21
Adipose	intron excision ratio	0	0	1.11
Adipose	mRNA stability	0	0	1.13
BLA	alternative polyA	0	0	1.18
BLA	alternative TSS	0	0	1.07
BLA	gene expression	0	0	1.16
BLA	isoform ratio	0	0	1.13
BLA	intron excision ratio	0	0	1.19
BLA	mRNA stability	0	0	1.1
Brain	alternative polyA	0	0	1.14
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.15
Brain	isoform ratio	0	0	1.17
Brain	intron excision ratio	0	0	1.14
Brain	mRNA stability	0	0	1.16
Eye	alternative polyA	0	0	1.33
Eye	alternative TSS	0	0	1.23
Eye	gene expression	0	0	1.13
Eye	isoform ratio	0	0	1.2
Eye	intron excision ratio	0	0	1.1
Eye	mRNA stability	0	0	1.3
IL	alternative polyA	0	0	1.35
IL	alternative TSS	0	0	1.22
IL	gene expression	0	0	1.19
IL	isoform ratio	0	0	1.26
IL	intron excision ratio	0	0	1.32
IL	mRNA stability	0	0	1.2
LHb	alternative polyA	0	0	1.24
LHb	alternative TSS	0	0	1.28
LHb	gene expression	0	0	1.22
LHb	isoform ratio	0	0	1.21
LHb	intron excision ratio	0	0	1.31
LHb	mRNA stability	0	0	1.23
Liver	alternative polyA	0	0	1.13
Liver	alternative TSS	0	0	1.04
Liver	gene expression	0	0	1.16
Liver	isoform ratio	1	0	1.18
Liver	intron excision ratio	0	0	1.15
Liver	mRNA stability	0	0	1.18
NAcc	alternative polyA	0	0	1.11
NAcc	alternative TSS	0	0	1.15
NAcc	gene expression	0	0	1.18
NAcc	isoform ratio	0	0	1.17
NAcc	intron excision ratio	0	0	1.16
NAcc	mRNA stability	0	0	1.16
OFC	alternative polyA	0	0	1.23
OFC	alternative TSS	0	0	1.2
OFC	gene expression	0	0	1.2
OFC	isoform ratio	0	0	1.3
OFC	intron excision ratio	0	0	1.32
OFC	mRNA stability	0	0	1.17
PL	alternative polyA	0	0	1.13
PL	alternative TSS	2	0.2	1.2
PL	gene expression	0	0	1.17
PL	isoform ratio	0	0	1.18
PL	intron excision ratio	0	0	1.14
PL	mRNA stability	0	0	1.17