Hub : Traits

Short access day 10 total inactive lever presses

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	8	65409201	66802272	1	1	3.52e-07	1.34e-02	2.95e-02	Plekho2
2	8	108584253	109479622	1	1	2.70e-11	1.64e-03	4.67e-03	Apeh
3	9	24497174	25018277	1	1	1.21e-08	5.74e-03	1.00e+00	Rims1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Liver weight, left	3.97	1	0	0	0	1e+00	Apeh
Extensor digitorum longus weight	1.46	1	0	0	0	1e+00	Plekho2
Std. dev. time between licks in bursts	6.89	1	0	0	0	1e+00	Apeh
Indifference point 0 sec	3.78	1	0	0	0	1e+00	Apeh
Delay discounting total patch changes 18 sec	5.91	1	0	0	0	1e+00	Apeh
Delay discounting total patch changes 6 sec	4.88	1	0	0	0	1e+00	Apeh
Light reinforcement 2	7.69	1	0	0	0	1e+00	Rims1
Saline control response	4.42	1	0	0	0	1e+00	Apeh
Conditioned reinforcement - inactives	18.86	2	1	33.3	0	1e+00	Rims1 Apeh
Conditioned locomotion	5.27	1	0	0	0	1e+00	Apeh
Intermittent access intake day 1-15 change	26.8	1	1	33.3	0	1e+00	Apeh
Intermittent access intake escalation	21.18	1	0	0	0	1e+00	Apeh
Intermittent access intake escalation 2	29.8	1	1	33.3	0	1e+00	Apeh
Intermitt. access day 1 inactive lever presses	15.13	1	0	0	0	1e+00	Rims1
Intermitt. access day 15 inactive lever presses	17.53	2	1	33.3	0	1e+00	Rims1 Apeh
Intermittent access standard deviation	34.31	1	1	33.3	0	1e+00	Apeh
Cocaine induced anxiety	6.44	1	0	0	0	1e+00	Apeh
Incentive Sensitization - Responses	8.56	2	0	0	0	1e+00	Rims1 Apeh
Incentive Sensitization - Breakpoint	7.55	2	0	0	0	1e+00	Rims1 Apeh
Progressive ratio test 1 active lever presses	10.83	2	0	0	0	1e+00	Rims1 Apeh
Progressive ratio test 1 breakpoint	12.15	2	0	0	0	1e+00	Rims1 Apeh
Progressive ratio test 1 inactive lever presses	8.51	1	0	0	0	1e+00	Apeh
Progressive ratio test 2 active lever presses	14.22	1	0	0	0	1e+00	Rims1
Progressive ratio test 2 breakpoint	16.36	1	0	0	0	1e+00	Rims1
Progressive ratio test 2 inactive lever presses	41.52	1	1	33.3	0	1e+00	Apeh
Total sessions with >9 infusions	12.6	1	0	0	0	1e+00	Apeh
Short access day 1 total inactive lever presses	7.7	1	0	0	0	1e+00	Apeh
Short access total infusions	5.45	1	0	0	0	1e+00	Rims1
Short access day 10 total locomotion	6.38	1	0	0	0	1e+00	Apeh
Short access total locomotion	10.65	1	0	0	0	1e+00	Apeh
Compulsive drug intake	7.66	1	0	0	0	1e+00	Apeh
Number of responses in last shaping day	12	1	0	0	0	1e+00	Apeh
Locomotion distance, session 1	4.48	1	0	0	0	1e+00	Plekho2
Locomotion velocity, session 3	6.63	1	0	0	0	1e+00	Rims1
Novel to familiar place preference ratio	6.25	1	0	0	0	1e+00	Apeh
Novelty place preference	7.01	1	0	0	0	1e+00	Apeh
Time in novel zone, NPP test	6.78	1	0	0	0	1e+00	Apeh
Pavlov. Cond. magazine entry latency	5.36	1	0	0	0	1e+00	Apeh
Pavlov. Cond. lever-magazine prob. diff.	4.88	1	0	0	0	1e+00	Apeh
Pavlov. Cond. response bias	5.32	1	0	0	0	1e+00	Apeh
Distance traveled before self-admin	5.8	1	0	0	0	1e+00	Rims1
Extinction: sum of active levers before priming	27.4	1	1	33.3	0	1e+00	Rims1
Delta distance traveled before/after self-admin	12.16	1	0	0	0	1e+00	Rims1
Delta ambulatory time before/after self-admin	5.33	1	0	0	0	1e+00	Rims1
Time in closed arm after self-admin	7.54	1	0	0	0	1e+00	Rims1
Time to tail flick, vehicle, before self-admin	9.4	1	0	0	0	1e+00	Rims1
Ambulatory time before self-admin	10.3	1	0	0	0	1e+00	Apeh
Time >=10cm from walls, locomotor time 1	29.01	1	1	33.3	0	1e+00	Rims1
Bouts of movement, locomotor time 1	5.95	1	0	0	0	1e+00	Rims1
Total resting periods, locomotor time 1	6.96	1	0	0	0	1e+00	Rims1
Vertical activity count, locomotor time 1	6.12	1	0	0	0	1e+00	Rims1
Bouts of movement, locomotor time 2	26.45	1	1	33.3	0	1e+00	Rims1
Total resting periods, locomotor time 2	30.91	1	1	33.3	0	1e+00	Rims1
Locomotion in novel chamber post-restriction	5.15	1	0	0	0	1e+00	Rims1
Cu content in liver	4.82	1	0	0	0	1e+00	Apeh

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.1
Adipose	alternative TSS	0	0	1.12
Adipose	gene expression	0	0	1.1
Adipose	isoform ratio	0	0	1.07
Adipose	intron excision ratio	0	0	1.06
Adipose	mRNA stability	0	0	1.1
BLA	alternative polyA	0	0	1.14
BLA	alternative TSS	0	0	1.12
BLA	gene expression	0	0	1.13
BLA	isoform ratio	0	0	1.14
BLA	intron excision ratio	0	0	1.05
BLA	mRNA stability	0	0	1.19
Brain	alternative polyA	0	0	1.13
Brain	alternative TSS	0	0	1.17
Brain	gene expression	0	0	1.08
Brain	isoform ratio	0	0	1.08
Brain	intron excision ratio	0	0	1.05
Brain	mRNA stability	1	0	1.11
Eye	alternative polyA	0	0	1.19
Eye	alternative TSS	0	0	1.2
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	1.07
Eye	intron excision ratio	0	0	1.02
Eye	mRNA stability	0	0	1
IL	alternative polyA	0	0	1.15
IL	alternative TSS	0	0	1.02
IL	gene expression	0	0	1.09
IL	isoform ratio	0	0	1.18
IL	intron excision ratio	0	0	1.15
IL	mRNA stability	0	0	1.17
LHb	alternative polyA	0	0	1.21
LHb	alternative TSS	0	0	1.07
LHb	gene expression	0	0	1.1
LHb	isoform ratio	0	0	1.15
LHb	intron excision ratio	0	0	1.17
LHb	mRNA stability	0	0	1.1
Liver	alternative polyA	0	0	1.1
Liver	alternative TSS	0	0	1.04
Liver	gene expression	0	0	1.09
Liver	isoform ratio	0	0	1.03
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.12
NAcc	alternative polyA	0	0	1.14
NAcc	alternative TSS	0	0	1.13
NAcc	gene expression	1	0	1.12
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.1
NAcc	mRNA stability	0	0	1.16
OFC	alternative polyA	0	0	1.21
OFC	alternative TSS	0	0	1.04
OFC	gene expression	0	0	1.1
OFC	isoform ratio	0	0	1.12
OFC	intron excision ratio	0	0	1.07
OFC	mRNA stability	0	0	1.12
PL	alternative polyA	0	0	1.19
PL	alternative TSS	0	0	1.12
PL	gene expression	0	0	1.13
PL	isoform ratio	0	0	1.15
PL	intron excision ratio	0	0	1.06
PL	mRNA stability	1	0	1.16