Hub : Traits

Short access day 1 total inactive lever presses

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	1.81e-07	6.25e-02	2.58e-01	Syt5
2	3	2116113	2932438	1	1	1.30e-08	2.36e-02	5.11e-21	ENSRNOG00000069208
3	14	46020357	47414802	1	1	9.28e-08	1.57e-01	1.00e+00	Arap2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	2.27	2	0	0	0	1e+00	Syt5 Arap2
Epididymis fat weight	3.75	1	0	0	0	1e+00	Arap2
Glucose	12.08	1	0	0	0	1e+00	Syt5
Left kidney weight	2.23	1	0	0	0	1e+00	Arap2
Right kidney weight	2.57	1	0	0	0	1e+00	Syt5
Length without tail	3.49	2	0	0	0	1e+00	Syt5 Arap2
Liver weight, left	10.21	1	0	0	0	1e+00	Syt5
Liver weight, right	11.2	1	0	0	0	1e+00	Syt5
Extensor digitorum longus weight	2.63	1	0	0	0	1e+00	Arap2
Tibialis anterior weight	2.35	1	0	0	0	1e+00	Syt5
Tibia length	7.53	1	0	0	0	1e+00	Syt5
Std. dev. time between licks in bursts	22.72	1	1	33.3	0	1e+00	Syt5
Indifference point 0 sec	6.32	1	0	0	0	1e+00	Syt5
Indifference point function ln k	8.79	1	0	0	0	1e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 12 sec	4.57	1	0	0	0	1e+00	ENSRNOG00000069208
Delay discounting total patch changes 24 sec	8	2	0	0	0	1e+00	Syt5 ENSRNOG00000069208
Delay discounting time to switch 0 sec	33.45	2	1	33.3	0	1e+00	Syt5 Arap2
Delay discounting water rate 0 sec	8.78	2	0	0	0	1e+00	Syt5 Arap2
Delay discounting water rate 12 sec	22.12	1	1	33.3	0	1e+00	Syt5
Delay discounting water rate 18 sec	14.32	2	0	0	0	1e+00	Syt5 Arap2
Delay discounting water rate 24 sec	7.99	1	0	0	0	1e+00	Syt5
Light reinforcement 1	10.07	3	1	33.3	0	1e+00	Syt5 Arap2 ENSRNOG00000069208
Light reinforcement 2	21.57	1	1	33.3	0	1e+00	Syt5
Reaction time number correct	4.57	1	0	0	0	1e+00	ENSRNOG00000069208
Reaction time num false alarms	11.21	1	0	0	0	1e+00	Arap2
Reaction time num false alarms AUC	10.08	2	0	0	0	1e+00	Syt5 Arap2
Reaction time trials correct on left	4.57	1	0	0	0	1e+00	ENSRNOG00000069208
Reaction time trials on left	4.65	1	0	0	0	1e+00	ENSRNOG00000069208
Reaction time mean	5.11	1	0	0	0	1e+00	Syt5
Reaction time mean AUC	5.48	2	0	0	0	1e+00	Syt5 Arap2
Median of all reaction times	6.98	1	0	0	0	1e+00	Syt5
Reaction time omissions	5.26	1	0	0	0	1e+00	Syt5
Reaction time false alarm rate	6.2	2	0	0	0	1e+00	Syt5 ENSRNOG00000069208
Reaction time trials completed	4.65	1	0	0	0	1e+00	ENSRNOG00000069208
Reaction time trials AUC	4.42	1	0	0	0	1e+00	ENSRNOG00000069208
Social response proportion	7.98	1	0	0	0	1e+00	Syt5
Social time	18.13	1	0	0	0	1e+00	Syt5
Conditioned locomotion	5.89	1	0	0	0	1e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	0	1e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1e+00	Syt5
Saline control response	13.17	1	0	0	0	1e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1e+00	Syt5
Pavlov. Cond. change in total contacts	5.35	2	0	0	0	1e+00	Syt5 Arap2
Pavlov. Cond. lever contacts	5.44	1	0	0	0	1e+00	Arap2
Pavlov. Cond. intertrial magazine entries	4.63	1	0	0	0	1e+00	Arap2
Conditioned reinforcement - actives	22.28	1	0	0	0	1e+00	Syt5
Conditioned reinforcement - inactives	16.81	1	0	0	0	1e+00	Arap2
Conditioned locomotion	15.14	1	0	0	0	1e+00	Syt5
Intermittent access intake day 1-15 change	10.89	2	0	0	0	1e+00	Syt5 Arap2
Intermittent access intake escalation	10.8	1	0	0	0	1e+00	Arap2
Intermittent access intake escalation 2	10.05	1	0	0	0	1e+00	Arap2
Intermitt. access day 1 inactive lever presses	13.59	3	0	0	0	1e+00	Syt5 Arap2 ENSRNOG00000069208
Intermitt. access day 15 inactive lever presses	24.14	2	1	33.3	0	1e+00	Syt5 Arap2
Intermitt. access escalation Index	19.85	2	0	0	0	1e+00	Syt5 Arap2
Intermittent access standard deviation	9.35	1	0	0	0	1e+00	Syt5
Post-drug Anxiety	8.09	2	0	0	0	1e+00	Syt5 ENSRNOG00000069208
Baseline Anxiety	17.76	2	1	33.3	0	1e+00	Syt5 Arap2
Incentive Sensitization - Responses	6.78	1	0	0	0	1e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1e+00	Syt5
Progressive ratio test 1 inactive lever presses	6.23	1	0	0	0	1e+00	ENSRNOG00000069208
Short access day 10 total inactive lever presses	19.99	1	0	0	0	1e+00	ENSRNOG00000069208
Short access day 10 total locomotion	11.18	1	0	0	0	1e+00	Syt5
Short access total locomotion	10.8	2	0	0	0	1e+00	Syt5 Arap2
One hour access (0.3 mA shock)	5.22	1	0	0	0	1e+00	Arap2
One hour access (shock baseline)	24.39	1	1	33.3	0	1e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 1	61.51	1	1	33.3	0	1e+00	Syt5
Locomotion distance, session 1	22.42	1	1	33.3	0	1e+00	Syt5
Locomotion velocity, session 2	12.85	2	0	0	0	1e+00	Syt5 Arap2
Locomotion distance, session 2	5.29	2	0	0	0	1e+00	Syt5 ENSRNOG00000069208
Locomotion distance, session 3	8.71	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 7	5.99	1	0	0	0	1e+00	Syt5
Locomotion distance, session 7	7.93	2	0	0	0	1e+00	Syt5 Arap2
Locomotion velocity, session 8	15.73	1	0	0	0	1e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1e+00	Syt5
Condit. Reinf. active responses	16.38	1	0	0	0	1e+00	Arap2
Condit. Reinf. inactive responses	15.36	1	0	0	0	1e+00	Arap2
Incentive salience index mean	5.87	1	0	0	0	1e+00	Arap2
Time in familiar zone, hab. session 1	12.82	1	0	0	0	1e+00	Syt5
Total zone transitions, hab. session 1	15.18	2	1	33.3	0	1e+00	Syt5 ENSRNOG00000069208
Total locomotion distance, hab. session 1	19.26	1	1	33.3	0	1e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1e+00	Syt5
Total zone transitions, hab. session 2	7.11	2	0	0	0	1e+00	Syt5 Arap2
Total locomotion distance, hab. session 2	10.72	1	0	0	0	1e+00	Syt5
Locomotion velocity, hab. session 2	13.63	1	0	0	0	1e+00	Syt5
Total zone transitions, NPP test	4.66	2	0	0	0	1e+00	Syt5 ENSRNOG00000069208
Total locomotion distance, NPP test	11.26	1	0	0	0	1e+00	Arap2
Locomotion velocity, NPP test	10.17	1	0	0	0	1e+00	Arap2
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1e+00	Syt5
Pavlov. Cond. change in total contacts	14.48	1	0	0	0	1e+00	Arap2
Pavlov. Cond. intertrial magazine entries	16.39	2	0	0	0	1e+00	Syt5 Arap2
Pavlov. Cond. response bias	13.37	1	0	0	0	1e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	0	1e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	0	1e+00	Syt5
Bone: elastic work	5.83	1	0	0	0	1e+00	Syt5
Bone: post-yield work	11.59	1	0	0	0	1e+00	Syt5
Bone: stiffness	4.47	1	0	0	0	1e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1e+00	Syt5
Distance traveled before self-admin	57.56	1	1	33.3	0	1e+00	Syt5
Distance traveled after self-admin	56.65	1	1	33.3	0	1e+00	Syt5
Delta time in closed arm before/after self-admin	11.55	1	0	0	0	1e+00	ENSRNOG00000069208
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	33.3	0	1e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	0	1e+00	Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1e+00	Syt5
Time to tail flick, vehicle, before self-admin	6.98	1	0	0	0	1e+00	Arap2
Time to tail flick, test, before self-admin	57.17	1	1	33.3	0	1e+00	Syt5
Time to tail flick, test, after self-admin	6.96	2	0	0	0	1e+00	Syt5 Arap2
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	33.3	0	1e+00	Syt5
Ambulatory time before self-admin	21.18	2	1	33.3	0	1e+00	Syt5 Arap2
Ambulatory time after self-admin	33.68	2	1	33.3	0	1e+00	Syt5 ENSRNOG00000069208
Total heroin consumption	7.83	2	0	0	0	1e+00	Syt5 Arap2
Delay disc. indifference point, 0s delay	27.96	1	1	33.3	0	1e+00	Syt5
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 2s delay	7.36	1	0	0	0	1e+00	Arap2
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1e+00	Syt5
Change in fecal boli incidents, locomotor task	15.71	2	0	0	0	1e+00	Syt5 Arap2
Bouts of movement, locomotor time 1	31.75	2	1	33.3	0	1e+00	Syt5 ENSRNOG00000069208
Total resting periods, locomotor time 1	23.01	2	1	33.3	0	1e+00	Syt5 ENSRNOG00000069208
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1e+00	Syt5
Rest time, locomotor task time 2	9.12	1	0	0	0	1e+00	Syt5
Vertical activity count, locomotor time 2	5.62	1	0	0	0	1e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	33.3	0	1e+00	Syt5
Locomotion in novel chamber	10.8	2	0	0	0	1e+00	Syt5 Arap2
Locomotion in novel chamber post-restriction	22.09	1	1	33.3	0	1e+00	Arap2
Progressive ratio	7.56	1	0	0	0	1e+00	Syt5
Food seeking constrained by brief footshock	50.11	3	1	33.3	0	1e+00	Syt5 Arap2 ENSRNOG00000069208
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1e+00	Syt5
Run reversals in cocaine runway, females	8.33	1	0	0	0	1e+00	Syt5
Cd content in liver	7.16	2	0	0	0	1e+00	Syt5 Arap2
Co content in liver	19.37	1	0	0	0	1e+00	Syt5
Fe content in liver	6.2	1	0	0	0	1e+00	ENSRNOG00000069208
Rb content in liver	6.49	1	0	0	0	1e+00	Syt5
Se content in liver	10	1	0	0	0	1e+00	Arap2
Sr content in liver	66.74	1	1	33.3	0	1e+00	Syt5
Zn content in liver	12.43	1	0	0	0	1e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.06
Adipose	alternative TSS	0	0	1.18
Adipose	gene expression	0	0	1.11
Adipose	isoform ratio	0	0	1.11
Adipose	intron excision ratio	0	0	1.1
Adipose	mRNA stability	0	0	1.14
BLA	alternative polyA	0	0	1.05
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	1.13
BLA	isoform ratio	0	0	1.11
BLA	intron excision ratio	0	0	1.06
BLA	mRNA stability	1	0	1.18
Brain	alternative polyA	0	0	1.1
Brain	alternative TSS	0	0	1.11
Brain	gene expression	0	0	1.11
Brain	isoform ratio	0	0	1.18
Brain	intron excision ratio	0	0	1.1
Brain	mRNA stability	0	0	1.17
Eye	alternative polyA	0	0	1.22
Eye	alternative TSS	0	0	1.17
Eye	gene expression	0	0	1.19
Eye	isoform ratio	0	0	1.14
Eye	intron excision ratio	0	0	1.02
Eye	mRNA stability	0	0	1.18
IL	alternative polyA	0	0	1.01
IL	alternative TSS	0	0	1.03
IL	gene expression	0	0	1.11
IL	isoform ratio	0	0	1.1
IL	intron excision ratio	0	0	1.13
IL	mRNA stability	0	0	1.23
LHb	alternative polyA	0	0	1.08
LHb	alternative TSS	0	0	1.09
LHb	gene expression	0	0	1.13
LHb	isoform ratio	0	0	1.14
LHb	intron excision ratio	0	0	1.02
LHb	mRNA stability	0	0	1.18
Liver	alternative polyA	0	0	1
Liver	alternative TSS	0	0	1.11
Liver	gene expression	1	0	1.13
Liver	isoform ratio	0	0	1.17
Liver	intron excision ratio	0	0	1.06
Liver	mRNA stability	0	0	1.14
NAcc	alternative polyA	0	0	1.02
NAcc	alternative TSS	0	0	1.09
NAcc	gene expression	0	0	1.15
NAcc	isoform ratio	0	0	1.11
NAcc	intron excision ratio	0	0	1.07
NAcc	mRNA stability	1	0	1.15
OFC	alternative polyA	0	0	1.13
OFC	alternative TSS	0	0	1.03
OFC	gene expression	0	0	1.1
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1.15
OFC	mRNA stability	0	0	1.19
PL	alternative polyA	0	0	1.07
PL	alternative TSS	0	0	1.14
PL	gene expression	0	0	1.12
PL	isoform ratio	0	0	1.14
PL	intron excision ratio	0	0	1.14
PL	mRNA stability	0	0	1.18