Hub : Traits

Progressive ratio test 2 inactive lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	84591076	85984018	1	1	3.46e-07	7.76e-03	3.43e-01	Zfp14
2	8	108584253	109479622	1	1	4.42e-12	5.20e-03	2.46e-04	Apeh
3	11	39057816	40174684	1	1	5.69e-09	1.06e-01	1.00e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	1.89	1	0	0	0	1.00e+00	Zfp14
Heart weight	4.41	1	0	0	0	1.00e+00	Epha6
Left kidney weight	6.11	1	0	0	0	1.00e+00	Zfp14
Right kidney weight	5.73	1	0	0	0	1.00e+00	Zfp14
Liver weight, left	3.97	1	0	0	0	1.00e+00	Apeh
Parametrial fat weight	15.44	2	1	33.3	0	1.00e+00	Epha6 Zfp14
Intraocular pressure	5.23	1	0	0	0	1.00e+00	Epha6
Tibia length	2.39	1	0	0	0	1.00e+00	Epha6
Food consumed during 24 hour testing period	5.68	1	0	0	0	1.00e+00	Epha6
Times rat made contact with spout	14.73	1	0	0	0	1.00e+00	Epha6
Std. dev. time between licks in bursts	6.89	1	0	0	0	1.00e+00	Apeh
Water consumed over 24 hours	15.6	1	0	0	0	1.00e+00	Epha6
Indifference point AUC	7.37	1	0	0	0	1.00e+00	Zfp14
Delay discounting total patch changes 12 sec	11.65	1	0	0	0	1.00e+00	Epha6
Delay discounting total patch changes 18 sec	10.73	2	0	0	0	1.00e+00	Epha6 Apeh
Delay discounting total patch changes 6 sec	9.33	2	0	0	0	1.00e+00	Epha6 Apeh
Delay discounting water rate 18 sec	10.64	2	0	0	0	1.00e+00	Epha6 Zfp14
Delay discounting water rate 24 sec	15.39	1	0	0	0	1.00e+00	Zfp14
Locomotor activity	6.32	2	0	0	0	1.00e+00	Epha6 Zfp14
Locomotor testing distance	7.95	1	0	0	0	1.00e+00	Epha6
Reaction time premature initiation rate	8.75	1	0	0	0	1.00e+00	Epha6
Reaction time premature initiations	5.85	1	0	0	0	1.00e+00	Epha6
Conditioned locomotion	14.73	1	0	0	0	1.00e+00	Epha6
Cocaine response before conditioning	7.22	2	0	0	0	1.00e+00	Epha6 Zfp14
Condit. Reinf. lever presses	6.01	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. lever latency	5.89	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. lever contacts	7.02	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry number	6.55	1	0	0	0	1.00e+00	Epha6
Conditioned reinforcement - actives	21.15	1	0	0	0	1.00e+00	Epha6
Conditioned reinforcement - inactives	24.8	3	2	66.7	1	9.09e-04	Epha6 Apeh Zfp14
Conditioned locomotion	6.29	2	0	0	0	1.00e+00	Apeh Zfp14
Intermittent access intake day 1-15 change	26.8	1	1	33.3	0	1.00e+00	Apeh
Intermittent access intake escalation	21.18	1	0	0	0	1.00e+00	Apeh
Intermittent access intake escalation 2	29.8	1	1	33.3	0	1.00e+00	Apeh
Intermitt. access day 15 inactive lever presses	27.39	1	1	33.3	0	1.00e+00	Apeh
Intermitt. access escalation Index	7.17	1	0	0	0	1.00e+00	Zfp14
Intermittent access day 1 total infusions	11.97	2	0	0	0	1.00e+00	Epha6 Zfp14
Intermittent access day 15 total infusions	13.11	2	0	0	0	1.00e+00	Epha6 Zfp14
Intermittent access terminal intake (last 3 days)	19.74	2	0	0	0	1.00e+00	Epha6 Zfp14
Intermittent access total infusions	16.84	2	0	0	0	1.00e+00	Epha6 Zfp14
Intermittent access day 1 locomotion	8.99	1	0	0	0	1.00e+00	Zfp14
Intermittent access standard deviation	34.31	1	1	33.3	0	1.00e+00	Apeh
Cocaine induced anxiety	12.4	2	0	0	0	1.00e+00	Epha6 Apeh
Post-drug Anxiety	5.89	1	0	0	0	1.00e+00	Epha6
Baseline Anxiety	18.76	1	0	0	0	1.00e+00	Epha6
Lifetime Intake	24.09	2	1	33.3	0	1.00e+00	Epha6 Zfp14
Incentive Sensitization - Responses	9.08	2	0	0	0	1.00e+00	Epha6 Apeh
Incentive Sensitization - Breakpoint	8.82	2	0	0	0	1.00e+00	Epha6 Apeh
Progressive ratio test 1 active lever presses	17.81	3	1	33.3	0.61	3.93e-01	Epha6 Apeh Zfp14
Progressive ratio test 1 breakpoint	19.6	3	1	33.3	0.62	3.76e-01	Epha6 Apeh Zfp14
Progressive ratio test 1 inactive lever presses	8.95	2	0	0	0	1.00e+00	Epha6 Apeh
Progressive ratio test 2 active lever presses	23.5	2	1	33.3	0	1.00e+00	Epha6 Zfp14
Progressive ratio test 2 breakpoint	18.15	2	1	33.3	0	1.00e+00	Epha6 Zfp14
Total sessions with >9 infusions	14.68	2	0	0	0	1.00e+00	Epha6 Apeh
Short access day 1 total inactive lever presses	7.78	3	0	0	0.98	1.95e-02	Epha6 Apeh Zfp14
Short access day 10 total inactive lever presses	40.3	1	1	33.3	0	1.00e+00	Apeh
Short access day 1 total infusions	37.11	1	1	33.3	0	1.00e+00	Epha6
Short access day 10 total infusions	6.17	1	0	0	0	1.00e+00	Zfp14
Short access total infusions	40.36	1	1	33.3	0	1.00e+00	Epha6
Short access day 10 total locomotion	6.38	1	0	0	0	1.00e+00	Apeh
Short access total locomotion	10.65	1	0	0	0	1.00e+00	Apeh
Compulsive drug intake	7.66	1	0	0	0	1.00e+00	Apeh
One hour access (0.3 mA shock)	24.94	2	1	33.3	0	1.00e+00	Epha6 Zfp14
One hour access (shock baseline)	16.75	2	0	0	0	1.00e+00	Epha6 Zfp14
Number of responses in last shaping day	12	1	0	0	0	1.00e+00	Apeh
Locomotion distance, session 1	10.11	1	0	0	0	1.00e+00	Epha6
Stereotopy head waving bouts, day 3	8.94	1	0	0	0	1.00e+00	Epha6
Locomotion velocity, session 7	6.82	1	0	0	0	1.00e+00	Epha6
Locomotion distance, session 7	12.27	1	0	0	0	1.00e+00	Epha6
Stereotopy head waving bouts, day 7	5.97	1	0	0	0	1.00e+00	Zfp14
Locomotion distance, session 8	5.02	1	0	0	0	1.00e+00	Epha6
Degree of sensitization stereotypy	11.13	1	0	0	0	1.00e+00	Zfp14
Condit. Reinf. active minus inactive responses	9.43	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. active-inactive response ratio	8.4	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. active responses	7.45	1	0	0	0	1.00e+00	Epha6
Incentive salience index mean	10.79	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. lever presses	8.2	1	0	0	0	1.00e+00	Epha6
Time in familiar zone, hab. session 1	9.26	1	0	0	0	1.00e+00	Epha6
Time in novel zone, hab. session 1	10.19	2	0	0	0	1.00e+00	Epha6 Zfp14
Total zone transitions, hab. session 1	8.13	1	0	0	0	1.00e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	0	1.00e+00	Epha6
Locomotion velocity, hab. session 1	8.12	1	0	0	0	1.00e+00	Epha6
Time in familiar zone, hab. session 2	29.91	1	1	33.3	0	1.00e+00	Epha6
Time in novel zone, hab. session 2	25.18	1	1	33.3	0	1.00e+00	Epha6
Total zone transitions, hab. session 2	7.43	1	0	0	0	1.00e+00	Epha6
Total locomotion distance, hab. session 2	7.03	2	0	0	0	1.00e+00	Epha6 Zfp14
Locomotion velocity, hab. session 2	8.08	1	0	0	0	1.00e+00	Epha6
Novel to familiar place preference ratio	6.25	1	0	0	0	1.00e+00	Apeh
Novelty place preference	7.01	1	0	0	0	1.00e+00	Apeh
Time in novel zone, NPP test	6.78	1	0	0	0	1.00e+00	Apeh
Pavlov. Cond. lever latency	14.56	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry latency	18.3	3	1	33.3	-0.64	3.61e-01	Epha6 Apeh Zfp14
Pavlov. Cond. change in total contacts	7.31	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. index score	24.26	1	1	33.3	0	1.00e+00	Epha6
Pavlov. Cond. latency score	22.39	1	1	33.3	0	1.00e+00	Epha6
Pavlov. Cond. lever contacts	20.49	1	1	33.3	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry number	12.84	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	22.92	1	1	33.3	0	1.00e+00	Epha6
Pavlov. Cond. response bias	18.18	2	1	33.3	0	1.00e+00	Epha6 Apeh
Bone: apparent density	8.43	1	0	0	0	1.00e+00	Zfp14
Bone surface	4.1	2	0	0	0	1.00e+00	Epha6 Zfp14
Bone volume	3.84	1	0	0	0	1.00e+00	Zfp14
Bone: connectivity density	4.88	2	0	0	0	1.00e+00	Epha6 Zfp14
Bone: cortical thickness	13.39	1	0	0	0	1.00e+00	Epha6
Bone: endosteal estimation	3.29	1	0	0	0	1.00e+00	Epha6
Bone: marrow area	2.98	1	0	0	0	1.00e+00	Epha6
Bone: maximum diameter	6.08	1	0	0	0	1.00e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	0	1.00e+00	Epha6
Bone: stiffness	6.97	1	0	0	0	1.00e+00	Epha6
Bone: trabecular number	5.43	1	0	0	0	1.00e+00	Zfp14
Breakpoint value in progressive ratio session	11.42	1	0	0	0	1.00e+00	Zfp14
Diff in mean of infusions in LGA sessions	7.96	1	0	0	0	1.00e+00	Zfp14
Time in closed arm before self-admin	7.8	1	0	0	0	1.00e+00	Zfp14
Time in open arm before self-admin	10.65	1	0	0	0	1.00e+00	Zfp14
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1.00e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8	1	0	0	0	1.00e+00	Epha6
Ambulatory time before self-admin	10.3	1	0	0	0	1.00e+00	Apeh
Area under the delay curve	6.54	1	0	0	0	1.00e+00	Epha6
Delay disc. indifference point, 0s delay	11.52	1	0	0	0	1.00e+00	Epha6
Delay disc. indifference point, 16s delay	7.47	1	0	0	0	1.00e+00	Zfp14
Delay disc. indifference point, 4s delay	9.3	2	0	0	0	1.00e+00	Epha6 Zfp14
Delay disc. indifference point, 8s delay	7.89	1	0	0	0	1.00e+00	Epha6
Delay discount exponential model param	6.64	1	0	0	0	1.00e+00	Epha6
Delay discount hyperbolic model param	6.66	1	0	0	0	1.00e+00	Epha6
Bouts of movement, locomotor time 1	8.93	2	0	0	0	1.00e+00	Epha6 Zfp14
Total resting periods, locomotor time 1	6.51	1	0	0	0	1.00e+00	Zfp14
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1.00e+00	Epha6
Rest time, locomotor task time 2	5.68	1	0	0	0	1.00e+00	Epha6
Seeking ratio, delayed vs. immediate footshock	11.05	1	0	0	0	1.00e+00	Epha6
Locomotion in novel chamber post-restriction	15.32	1	0	0	0	1.00e+00	Epha6
Run reversals in cocaine runway, males	9.58	1	0	0	0	1.00e+00	Zfp14
Latency to leave start box in cocaine runway	8.54	1	0	0	0	1.00e+00	Epha6
Na content in liver	10.19	1	0	0	0	1.00e+00	Epha6
Rb content in liver	9.23	1	0	0	0	1.00e+00	Zfp14
Se content in liver	11.12	1	0	0	0	1.00e+00	Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.16
Adipose	alternative TSS	0	0	1.23
Adipose	gene expression	0	0	1.15
Adipose	isoform ratio	0	0	1.14
Adipose	intron excision ratio	0	0	1.05
Adipose	mRNA stability	0	0	1.14
BLA	alternative polyA	0	0	1.1
BLA	alternative TSS	0	0	1.06
BLA	gene expression	0	0	1.17
BLA	isoform ratio	0	0	1.15
BLA	intron excision ratio	0	0	1.1
BLA	mRNA stability	0	0	1.17
Brain	alternative polyA	0	0	1.18
Brain	alternative TSS	0	0	1.2
Brain	gene expression	0	0	1.15
Brain	isoform ratio	0	0	1.2
Brain	intron excision ratio	0	0	1.11
Brain	mRNA stability	0	0	1.17
Eye	alternative polyA	0	0	1.5
Eye	alternative TSS	0	0	1.18
Eye	gene expression	0	0	1.18
Eye	isoform ratio	0	0	1.14
Eye	intron excision ratio	0	0	1.04
Eye	mRNA stability	0	0	1.25
IL	alternative polyA	0	0	1.23
IL	alternative TSS	0	0	1.18
IL	gene expression	0	0	1.19
IL	isoform ratio	0	0	1.31
IL	intron excision ratio	0	0	1.18
IL	mRNA stability	0	0	1.21
LHb	alternative polyA	0	0	0.99
LHb	alternative TSS	0	0	1.22
LHb	gene expression	0	0	1.18
LHb	isoform ratio	0	0	1.16
LHb	intron excision ratio	0	0	1.08
LHb	mRNA stability	0	0	1.17
Liver	alternative polyA	0	0	1.08
Liver	alternative TSS	0	0	1.22
Liver	gene expression	1	0	1.15
Liver	isoform ratio	0	0	1.24
Liver	intron excision ratio	0	0	1.14
Liver	mRNA stability	0	0	1.2
NAcc	alternative polyA	0	0	1.06
NAcc	alternative TSS	0	0	1.22
NAcc	gene expression	0	0	1.17
NAcc	isoform ratio	0	0	1.16
NAcc	intron excision ratio	0	0	1.1
NAcc	mRNA stability	0	0	1.19
OFC	alternative polyA	0	0	1.11
OFC	alternative TSS	0	0	1.13
OFC	gene expression	0	0	1.21
OFC	isoform ratio	0	0	1.21
OFC	intron excision ratio	0	0	1.13
OFC	mRNA stability	0	0	1.15
PL	alternative polyA	0	0	1.12
PL	alternative TSS	2	0.2	1.24
PL	gene expression	0	0	1.18
PL	isoform ratio	0	0	1.19
PL	intron excision ratio	0	0	1.14
PL	mRNA stability	1	0	1.22