Hub : Traits

Progressive ratio test 1 active lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	11	39057816	40174684	1	1	1.91e-07	7.94e-04	1.00e+00	Epha6
2	16	44034037	45431861	1	1	1.81e-07	5.04e-03	3.88e-01	Trappc11

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	3.97	1	0	0	0	1e+00	Trappc11
BMI without tail	4.29	1	0	0	0	1e+00	Trappc11
Epididymis fat weight	2.65	1	0	0	0	1e+00	Trappc11
Parametrial fat weight	14.7	1	1	50	0	1e+00	Epha6
Tibia length	1.79	1	0	0	0	1e+00	Epha6
Food consumed during 24 hour testing period	5.68	1	0	0	0	1e+00	Epha6
Times rat made contact with spout	14.83	1	0	0	0	1e+00	Epha6
Water consumed over 24 hours	16.45	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 12 sec	8.8	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 18 sec	10	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 6 sec	9.49	1	0	0	0	1e+00	Epha6
Delay discounting water rate 18 sec	11.12	1	0	0	0	1e+00	Epha6
Delay discounting water rate 24 sec	4.34	1	0	0	0	1e+00	Trappc11
Locomotor activity	5.84	1	0	0	0	1e+00	Epha6
Locomotor testing distance	6.97	1	0	0	0	1e+00	Epha6
Light reinforcement 2	4	1	0	0	0	1e+00	Epha6
Reaction time premature initiation rate	6.82	2	0	0	0	1e+00	Trappc11 Epha6
Reaction time premature initiations	5.85	1	0	0	0	1e+00	Epha6
Social response proportion	10.96	1	0	0	0	1e+00	Trappc11
Conditioned locomotion	16.01	1	0	0	0	1e+00	Epha6
Cocaine response before conditioning	7.09	1	0	0	0	1e+00	Epha6
Condit. Reinf. lever presses	5.61	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	4.44	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever contacts	4.25	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	4.34	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - actives	20.71	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - inactives	22.32	1	0	0	0	1e+00	Epha6
Conditioned locomotion	9.7	1	0	0	0	1e+00	Trappc11
Intermittent access day 1 total infusions	10.53	2	0	0	0	1e+00	Trappc11 Epha6
Intermittent access day 15 total infusions	9.43	2	0	0	0	1e+00	Trappc11 Epha6
Intermittent access terminal intake (last 3 days)	12.82	2	0	0	0	1e+00	Trappc11 Epha6
Intermittent access total infusions	14.46	2	0	0	0	1e+00	Trappc11 Epha6
Intermittent access day 1 locomotion	12.18	1	0	0	0	1e+00	Trappc11
Intermittent access total locomotion	10.87	1	0	0	0	1e+00	Trappc11
Cocaine induced anxiety	13.12	1	0	0	0	1e+00	Epha6
Baseline Anxiety	17.77	1	0	0	0	1e+00	Epha6
Lifetime Intake	19.68	2	1	50	0	1e+00	Trappc11 Epha6
Incentive Sensitization - Responses	10.01	2	0	0	0	1e+00	Trappc11 Epha6
Incentive Sensitization - Breakpoint	8.78	2	0	0	0	1e+00	Trappc11 Epha6
Progressive ratio test 1 breakpoint	28	2	1	50	0	1e+00	Trappc11 Epha6
Progressive ratio test 1 inactive lever presses	8.6	2	0	0	0	1e+00	Trappc11 Epha6
Progressive ratio test 2 active lever presses	26.17	2	1	50	0	1e+00	Trappc11 Epha6
Progressive ratio test 2 breakpoint	23.47	2	1	50	0	1e+00	Trappc11 Epha6
Progressive ratio test 2 inactive lever presses	19.33	2	1	50	0	1e+00	Trappc11 Epha6
Total sessions with >9 infusions	13.07	1	0	0	0	1e+00	Epha6
Short access day 1 total inactive lever presses	9.19	2	0	0	0	1e+00	Trappc11 Epha6
Short access day 1 total infusions	19.59	2	1	50	0	1e+00	Trappc11 Epha6
Short access total infusions	21.65	2	1	50	0	1e+00	Trappc11 Epha6
Short access day 1 locomotion	9.67	1	0	0	0	1e+00	Trappc11
Short access total locomotion	11.13	1	0	0	0	1e+00	Trappc11
One hour access (0.3 mA shock)	23.3	2	1	50	0	1e+00	Trappc11 Epha6
One hour access (shock baseline)	18.95	2	0	0	0	1e+00	Trappc11 Epha6
Number of responses in last shaping day	10.88	1	0	0	0	1e+00	Trappc11
Locomotion distance, session 1	8.8	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 3	5.1	1	0	0	0	1e+00	Epha6
Locomotion velocity, session 7	5.93	1	0	0	0	1e+00	Epha6
Locomotion distance, session 7	13.26	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 7	4.79	1	0	0	0	1e+00	Trappc11
Stereotopy head waving duration, day 7	8.42	1	0	0	0	1e+00	Trappc11
Locomotion distance, session 8	4.54	1	0	0	0	1e+00	Epha6
Degree of sensitization stereotypy	6.59	1	0	0	0	1e+00	Trappc11
Condit. Reinf. active minus inactive responses	4.85	1	0	0	0	1e+00	Epha6
Condit. Reinf. active-inactive response ratio	7.36	1	0	0	0	1e+00	Epha6
Condit. Reinf. active responses	5.25	1	0	0	0	1e+00	Epha6
Incentive salience index mean	5.05	1	0	0	0	1e+00	Epha6
Condit. Reinf. lever presses	5.44	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 1	8.7	1	0	0	0	1e+00	Epha6
Time in novel zone, hab. session 1	6.66	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 1	4.05	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 2	22.56	1	0	0	0	1e+00	Epha6
Time in novel zone, hab. session 2	20.34	1	0	0	0	1e+00	Epha6
Total zone transitions, hab. session 2	4.79	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 2	7.51	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 2	7.18	1	0	0	0	1e+00	Epha6
Novelty place preference	5.48	1	0	0	0	1e+00	Epha6
Total zone transitions, NPP test	3.67	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	9.59	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry latency	27.66	1	1	50	0	1e+00	Epha6
Pavlov. Cond. change in total contacts	6.39	1	0	0	0	1e+00	Epha6
Pavlov. Cond. index score	19.32	1	0	0	0	1e+00	Epha6
Pavlov. Cond. latency score	17.92	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever contacts	15.42	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	10.94	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	18.27	1	0	0	0	1e+00	Epha6
Pavlov. Cond. response bias	19.54	1	0	0	0	1e+00	Epha6
Bone surface	4.24	1	0	0	0	1e+00	Epha6
Bone: connectivity density	4.61	1	0	0	0	1e+00	Epha6
Bone: cortical thickness	8.92	2	0	0	0	1e+00	Trappc11 Epha6
Bone: elastic displacement	6.64	1	0	0	0	1e+00	Trappc11
Bone: elastic work	6.31	1	0	0	0	1e+00	Trappc11
Bone: endosteal estimation	3.29	1	0	0	0	1e+00	Epha6
Bone: marrow area	2.98	1	0	0	0	1e+00	Epha6
Bone: maximum diameter	4.84	1	0	0	0	1e+00	Epha6
Bone: periosteal estimation	2.69	1	0	0	0	1e+00	Epha6
Bone: periosteal perimeter	3.06	1	0	0	0	1e+00	Epha6
Bone: stiffness	6.12	1	0	0	0	1e+00	Epha6
Distance traveled after self-admin	12.05	1	0	0	0	1e+00	Trappc11
Time to tail flick, test, before self-admin	5.53	1	0	0	0	1e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	7.91	1	0	0	0	1e+00	Epha6
Ambulatory time after self-admin	11.25	1	0	0	0	1e+00	Trappc11
Total heroin consumption	4.76	1	0	0	0	1e+00	Epha6
Area under the delay curve	6.54	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 0s delay	11.24	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 4s delay	10.2	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 8s delay	7.89	1	0	0	0	1e+00	Epha6
Delay discount exponential model param	6.64	1	0	0	0	1e+00	Epha6
Delay discount hyperbolic model param	6.66	1	0	0	0	1e+00	Epha6
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1e+00	Epha6
Time >=10cm from walls, locomotor time 2	9.34	1	0	0	0	1e+00	Trappc11
Seeking ratio, delayed vs. immediate footshock	10.93	1	0	0	0	1e+00	Epha6
Locomotion in novel chamber post-restriction	15.14	1	0	0	0	1e+00	Epha6
Latency to leave start box in cocaine runway	6.79	1	0	0	0	1e+00	Epha6
Na content in liver	10.99	1	0	0	0	1e+00	Epha6
Se content in liver	9.05	1	0	0	0	1e+00	Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.02
Adipose	alternative TSS	0	0	1.12
Adipose	gene expression	0	0	1.04
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	1
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	1.1
BLA	alternative TSS	0	0	0.96
BLA	gene expression	0	0	1.03
BLA	isoform ratio	0	0	0.96
BLA	intron excision ratio	0	0	0.98
BLA	mRNA stability	0	0	1.08
Brain	alternative polyA	0	0	1.04
Brain	alternative TSS	0	0	0.99
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.03
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	1.04
Eye	alternative polyA	0	0	1.51
Eye	alternative TSS	0	0	1.13
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.13
Eye	intron excision ratio	0	0	1.04
Eye	mRNA stability	0	0	1.16
IL	alternative polyA	0	0	1.05
IL	alternative TSS	0	0	1.13
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	1.03
IL	intron excision ratio	0	0	1.04
IL	mRNA stability	0	0	1.14
LHb	alternative polyA	0	0	1.11
LHb	alternative TSS	0	0	0.96
LHb	gene expression	0	0	1.07
LHb	isoform ratio	0	0	1.05
LHb	intron excision ratio	0	0	0.96
LHb	mRNA stability	0	0	1.1
Liver	alternative polyA	0	0	0.98
Liver	alternative TSS	0	0	1.05
Liver	gene expression	0	0	1.03
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	0	0	1.06
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	0	0	1.02
NAcc	alternative TSS	0	0	1.09
NAcc	gene expression	1	0	1.03
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	0.99
NAcc	mRNA stability	0	0	1.06
OFC	alternative polyA	0	0	1.22
OFC	alternative TSS	0	0	0.95
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.05
OFC	intron excision ratio	0	0	0.99
OFC	mRNA stability	0	0	1.1
PL	alternative polyA	0	0	1.08
PL	alternative TSS	1	0.1	1.14
PL	gene expression	0	0	1.03
PL	isoform ratio	0	0	1.04
PL	intron excision ratio	0	0	0.96
PL	mRNA stability	0	0	1.08