Hub : Traits

Mg content in liver

Tags: Physiology · Liver

Project: vulpe_liver_2014

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	46789397	48185455	1	1	4.64e-08	4.05e-01	2.19e-01	Trim16
2	18	3105227	4504638	1	1	4.51e-08	3.72e-05	4.52e-01	Ttc39c

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.79	1	0	0	0	1e+00	Ttc39c
Heart weight	7.82	1	0	0	0	1e+00	Trim16
Liver weight, left	7.8	1	0	0	0	1e+00	Trim16
Intraocular pressure	22.73	2	1	50	0	1e+00	Trim16 Ttc39c
Extensor digitorum longus weight	1.51	1	0	0	0	1e+00	Ttc39c
Tibia length	3	1	0	0	0	1e+00	Ttc39c
Number of licking bursts	19.25	1	0	0	0	1e+00	Trim16
Food consumed during 24 hour testing period	18.56	1	0	0	0	1e+00	Trim16
Times rat made contact with spout	16.5	1	0	0	0	1e+00	Trim16
Mean num. licks in bursts	46	1	1	50	0	1e+00	Trim16
Std. dev. time between licks in bursts	5.37	1	0	0	0	1e+00	Trim16
Water consumed over 24 hours	23.78	1	1	50	0	1e+00	Trim16
Indifference point 0 sec	6.06	2	0	0	0	1e+00	Trim16 Ttc39c
Delay discounting total patch changes 0 sec	6.38	2	0	0	0	1e+00	Trim16 Ttc39c
Delay discounting total patch changes 18 sec	45.74	1	1	50	0	1e+00	Trim16
Delay discounting total patch changes 24 sec	4.17	1	0	0	0	1e+00	Ttc39c
Delay discounting total patch changes 6 sec	5.53	2	0	0	0	1e+00	Trim16 Ttc39c
Delay discounting water rate 0 sec	15.05	1	0	0	0	1e+00	Trim16
Delay discounting water rate 6 sec	7.21	1	0	0	0	1e+00	Trim16
Locomotor activity	4.93	1	0	0	0	1e+00	Trim16
Reaction time number correct	7.52	1	0	0	0	1e+00	Trim16
Reaction time trials correct on left	7.52	1	0	0	0	1e+00	Trim16
Reaction time trials on left	6.91	1	0	0	0	1e+00	Trim16
Reaction time premature initiation rate	5	2	0	0	0	1e+00	Trim16 Ttc39c
Reaction time premature initiations	4.96	1	0	0	0	1e+00	Ttc39c
Reaction time trials completed	6.91	1	0	0	0	1e+00	Trim16
Reaction time trials AUC	5.96	1	0	0	0	1e+00	Trim16
Social responses	3.96	1	0	0	0	1e+00	Trim16
Social time	25.91	1	1	50	0	1e+00	Trim16
Cocaine response after cond. corrected	14.58	1	0	0	0	1e+00	Trim16
Cocaine response after cond. not corrected	16	1	0	0	0	1e+00	Trim16
Saline control response	8.82	1	0	0	0	1e+00	Ttc39c
Condit. Reinf. inactive responses	6.09	1	0	0	0	1e+00	Ttc39c
Condit. Reinf. lever presses	7.41	1	0	0	0	1e+00	Trim16
Intermitt. access day 1 inactive lever presses	36.63	1	1	50	0	1e+00	Trim16
Intermitt. access escalation Index	27.6	1	0	0	0	1e+00	Trim16
Intermittent access day 1 locomotion	12.82	1	0	0	0	1e+00	Trim16
Intermittent access total locomotion	9.87	1	0	0	0	1e+00	Trim16
Cocaine induced anxiety	31.69	1	1	50	0	1e+00	Trim16
Post-drug Anxiety	7.78	2	0	0	0	1e+00	Trim16 Ttc39c
Baseline Anxiety	29.94	1	1	50	0	1e+00	Trim16
Progressive ratio test 1 inactive lever presses	10.6	1	0	0	0	1e+00	Trim16
Total sessions with >9 infusions	13.7	1	0	0	0	1e+00	Trim16
Short access day 1 total inactive lever presses	13.77	1	0	0	0	1e+00	Trim16
Short access day 1 total infusions	62.7	1	1	50	0	1e+00	Trim16
Short access total infusions	5.05	1	0	0	0	1e+00	Trim16
Short access day 1 locomotion	33.14	1	1	50	0	1e+00	Trim16
Short access day 10 total locomotion	14.27	1	0	0	0	1e+00	Trim16
Short access total locomotion	10.11	1	0	0	0	1e+00	Trim16
Compulsive drug intake	11.93	1	0	0	0	1e+00	Trim16
Number of responses in last shaping day	25.55	1	1	50	0	1e+00	Trim16
Context. condit. distance diff. score	5	1	0	0	0	1e+00	Trim16
Locomotion distance, session 1	31.9	1	1	50	0	1e+00	Trim16
Locomotion distance, session 2	15.7	1	0	0	0	1e+00	Trim16
Locomotion velocity, session 7	4.97	1	0	0	0	1e+00	Trim16
Stereotopy head waving bouts, day 7	25.38	1	1	50	0	1e+00	Trim16
Stereotopy head waving duration, day 7	6.53	1	0	0	0	1e+00	Trim16
Degree of sensitization stereotypy	7.41	1	0	0	0	1e+00	Trim16
Condit. Reinf. active minus inactive responses	5.06	1	0	0	0	1e+00	Trim16
Condit. Reinf. active-inactive response ratio	5.08	1	0	0	0	1e+00	Trim16
Incentive salience index mean	5.91	1	0	0	0	1e+00	Trim16
Time in familiar zone, hab. session 1	6.6	1	0	0	0	1e+00	Trim16
Time in novel zone, hab. session 1	5.6	1	0	0	0	1e+00	Trim16
Total zone transitions, hab. session 1	37.38	1	1	50	0	1e+00	Trim16
Total locomotion distance, hab. session 1	38.46	1	1	50	0	1e+00	Trim16
Locomotion velocity, hab. session 1	30.22	1	1	50	0	1e+00	Trim16
Time in familiar zone, hab. session 2	8.57	1	0	0	0	1e+00	Trim16
Total locomotion distance, hab. session 2	11.5	1	0	0	0	1e+00	Trim16
Locomotion velocity, hab. session 2	9.98	1	0	0	0	1e+00	Trim16
Time in novel zone, NPP test	5.25	1	0	0	0	1e+00	Trim16
Total zone transitions, NPP test	3.64	1	0	0	0	1e+00	Trim16
Total locomotion distance, NPP test	4.55	1	0	0	0	1e+00	Trim16
Locomotion velocity, NPP test	3.97	1	0	0	0	1e+00	Trim16
Pavlov. Cond. lever latency	4.79	1	0	0	0	1e+00	Ttc39c
Pavlov. Cond. magazine entry latency	30.95	1	1	50	0	1e+00	Trim16
Pavlov. Cond. index score	10.8	1	0	0	0	1e+00	Trim16
Pavlov. Cond. latency score	5.87	1	0	0	0	1e+00	Trim16
Pavlov. Cond. magazine entry number	28.02	1	1	50	0	1e+00	Trim16
Pavlov. Cond. intertrial magazine entries	14.36	1	0	0	0	1e+00	Trim16
Pavlov. Cond. lever-magazine prob. diff.	10.24	1	0	0	0	1e+00	Trim16
Pavlov. Cond. response bias	8.26	1	0	0	0	1e+00	Trim16
Bone: cortical apparent density	18.12	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	21.5	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	27.37	1	1	50	0	1e+00	Trim16
Bone: cortical tissue density	19.62	1	0	0	0	1e+00	Trim16
Bone: elastic work	5.85	1	0	0	0	1e+00	Trim16
Bone: post-yield work	16.22	1	0	0	0	1e+00	Trim16
Bone: tissue strength	7.44	1	0	0	0	1e+00	Trim16
Delta ambulatory time before/after self-admin	4.72	1	0	0	0	1e+00	Ttc39c
Delay disc. indifference point, 16s delay	6.6	1	0	0	0	1e+00	Trim16
Distance moved, locomotor task time 2	6.59	1	0	0	0	1e+00	Trim16
Food seeking constrained by brief footshock	4.19	1	0	0	0	1e+00	Trim16
Run reversals in cocaine runway, females	11.6	1	0	0	0	1e+00	Trim16
Run reversals in cocaine runway, males	6.16	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway	10.73	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway, F	7.35	1	0	0	0	1e+00	Trim16
Cu content in liver	6.23	1	0	0	0	1e+00	Trim16
K content in liver	12.61	2	0	0	0	1e+00	Trim16 Ttc39c
Mn content in liver	6.21	2	0	0	0	1e+00	Trim16 Ttc39c
Na content in liver	5.06	1	0	0	0	1e+00	Ttc39c
Rb content in liver	24.76	1	1	50	0	1e+00	Trim16
Se content in liver	13.6	2	0	0	0	1e+00	Trim16 Ttc39c
Zn content in liver	5.53	1	0	0	0	1e+00	Ttc39c

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1
Adipose	alternative TSS	0	0	0.99
Adipose	gene expression	0	0	1.03
Adipose	isoform ratio	0	0	1.05
Adipose	intron excision ratio	0	0	1.05
Adipose	mRNA stability	0	0	1.03
BLA	alternative polyA	0	0	1.01
BLA	alternative TSS	0	0	0.94
BLA	gene expression	0	0	1
BLA	isoform ratio	0	0	1.02
BLA	intron excision ratio	0	0	1.12
BLA	mRNA stability	0	0	0.97
Brain	alternative polyA	0	0	1.05
Brain	alternative TSS	0	0	1.02
Brain	gene expression	0	0	1.03
Brain	isoform ratio	0	0	1
Brain	intron excision ratio	0	0	1.05
Brain	mRNA stability	0	0	1.01
Eye	alternative polyA	0	0	1.13
Eye	alternative TSS	0	0	0.92
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.01
Eye	intron excision ratio	1	0.2	1.15
Eye	mRNA stability	0	0	1.04
IL	alternative polyA	0	0	0.97
IL	alternative TSS	0	0	0.99
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	1.05
IL	intron excision ratio	0	0	1.1
IL	mRNA stability	0	0	0.96
LHb	alternative polyA	0	0	1.09
LHb	alternative TSS	0	0	0.94
LHb	gene expression	0	0	1.02
LHb	isoform ratio	0	0	1.11
LHb	intron excision ratio	0	0	1.19
LHb	mRNA stability	0	0	0.96
Liver	alternative polyA	0	0	1.11
Liver	alternative TSS	0	0	0.92
Liver	gene expression	0	0	1.03
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	1.07
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	0	0	1.04
NAcc	alternative TSS	0	0	0.91
NAcc	gene expression	0	0	1.03
NAcc	isoform ratio	0	0	1.03
NAcc	intron excision ratio	0	0	1.09
NAcc	mRNA stability	0	0	0.97
OFC	alternative polyA	0	0	1.08
OFC	alternative TSS	0	0	0.86
OFC	gene expression	0	0	1.03
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1.28
OFC	mRNA stability	0	0	0.98
PL	alternative polyA	0	0	1.02
PL	alternative TSS	0	0	0.85
PL	gene expression	1	0	1.03
PL	isoform ratio	0	0	1.08
PL	intron excision ratio	0	0	1.15
PL	mRNA stability	0	0	1.01