Hub : Traits

Bone: maximum diameter

Tags: Physiology · Bone

Project: r01_doug_adams

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	5	59640609	61037099	1	1	1.85e-07	1e-05	1.23e-02	Tmod1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Social time	4.08	1	0	0	0	1e+00	Tmod1
Intermittent access intake day 1-15 change	4.41	1	0	0	0	1e+00	Tmod1
Progressive ratio test 2 active lever presses	4.45	1	0	0	0	1e+00	Tmod1
Progressive ratio test 2 breakpoint	5.13	1	0	0	0	1e+00	Tmod1
Short access day 10 total locomotion	6.98	1	0	0	0	1e+00	Tmod1
Stereotopy head waving bouts, day 7	3.86	1	0	0	0	1e+00	Tmod1
Stereotopy head waving duration, day 7	3.71	1	0	0	0	1e+00	Tmod1
Degree of sensitization stereotypy	6.26	1	0	0	0	1e+00	Tmod1
Condit. Reinf. active minus inactive responses	4.23	1	0	0	0	1e+00	Tmod1
Condit. Reinf. active responses	5.14	1	0	0	0	1e+00	Tmod1
Incentive salience index mean	7.07	1	0	0	0	1e+00	Tmod1
Condit. Reinf. lever presses	5.27	1	0	0	0	1e+00	Tmod1
Pavlov. Cond. lever latency	3.34	1	0	0	0	1e+00	Tmod1
Pavlov. Cond. lever contacts	4.11	1	0	0	0	1e+00	Tmod1
Bone: cortical area	9.61	1	0	0	0	1e+00	Tmod1
Bone: cortical porosity	5.04	1	0	0	0	1e+00	Tmod1
Bone: cortical porosity	8.5	1	0	0	0	1e+00	Tmod1
Bone: elastic work	2.97	1	0	0	0	1e+00	Tmod1
Bone: endosteal perimeter	7.42	1	0	0	0	1e+00	Tmod1
Bone: minimum diameter	6.22	1	0	0	0	1e+00	Tmod1
Bone: periosteal estimation	5.67	1	0	0	0	1e+00	Tmod1
Bone: periosteal perimeter	17.71	1	1	100	0	1e+00	Tmod1
Bone: trabecular tissue density	3.05	1	0	0	0	1e+00	Tmod1
Zn content in liver	6.71	1	0	0	0	1e+00	Tmod1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.86
Adipose	alternative TSS	0	0	1.76
Adipose	gene expression	0	0	1.82
Adipose	isoform ratio	0	0	1.76
Adipose	intron excision ratio	0	0	2
Adipose	mRNA stability	0	0	1.83
BLA	alternative polyA	0	0	1.68
BLA	alternative TSS	0	0	1.74
BLA	gene expression	0	0	1.87
BLA	isoform ratio	0	0	1.69
BLA	intron excision ratio	0	0	1.78
BLA	mRNA stability	0	0	1.9
Brain	alternative polyA	0	0	1.85
Brain	alternative TSS	0	0	1.95
Brain	gene expression	0	0	1.83
Brain	isoform ratio	0	0	1.8
Brain	intron excision ratio	0	0	1.83
Brain	mRNA stability	0	0	1.79
Eye	alternative polyA	0	0	1.74
Eye	alternative TSS	0	0	1.73
Eye	gene expression	0	0	2.06
Eye	isoform ratio	0	0	1.66
Eye	intron excision ratio	0	0	1.82
Eye	mRNA stability	0	0	1.7
IL	alternative polyA	0	0	1.72
IL	alternative TSS	0	0	1.62
IL	gene expression	0	0	1.87
IL	isoform ratio	0	0	1.76
IL	intron excision ratio	0	0	1.82
IL	mRNA stability	0	0	1.84
LHb	alternative polyA	0	0	1.79
LHb	alternative TSS	0	0	2.03
LHb	gene expression	0	0	1.88
LHb	isoform ratio	0	0	1.76
LHb	intron excision ratio	0	0	1.89
LHb	mRNA stability	0	0	1.93
Liver	alternative polyA	1	0.1	1.78
Liver	alternative TSS	0	0	1.81
Liver	gene expression	0	0	1.83
Liver	isoform ratio	0	0	1.74
Liver	intron excision ratio	0	0	1.89
Liver	mRNA stability	0	0	1.82
NAcc	alternative polyA	0	0	1.8
NAcc	alternative TSS	0	0	1.83
NAcc	gene expression	0	0	1.84
NAcc	isoform ratio	0	0	1.77
NAcc	intron excision ratio	0	0	1.81
NAcc	mRNA stability	0	0	1.88
OFC	alternative polyA	0	0	1.73
OFC	alternative TSS	0	0	1.7
OFC	gene expression	0	0	1.92
OFC	isoform ratio	0	0	1.78
OFC	intron excision ratio	0	0	1.88
OFC	mRNA stability	0	0	1.95
PL	alternative polyA	0	0	1.8
PL	alternative TSS	0	0	1.8
PL	gene expression	0	0	1.88
PL	isoform ratio	0	0	1.7
PL	intron excision ratio	0	0	1.8
PL	mRNA stability	0	0	1.88